Nerve conduit of magnesium wire and silk compositely woven structure and preparation method of nerve conduit

Abstract

The invention discloses a nerve conduit of a magnesium wire and silk compositely woven structure and a preparation method of the nerve conduit. Medical metal magnesium wires with the high mechanical properties are adopted as axial yarn to be added into a silk woven structure, the longitudinal guiding effect is achieved, the radial compressive property of a woven skeleton can be further improved, meanwhile, the magnesium wires can be degraded slowly, growing and proliferating of Schwann cells are promoted, and injured nerves are recovered advantageously; and weaving yarn is degummed silk and has good biocompatibility, and a biological microenvironment for promoting nerve regeneration is formed while the good mechanical properties are ensured.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a nerve guide with a composite braided structure of magnesium silk and silk and a preparation method thereof. Background technique [0002] Peripheral nerve injury is a common clinical disease, and the use of biomaterials and tissue engineering technology to promote the repair and regeneration of defective nerves is a research hotspot in the field of neuroscience. Ideal biomaterials, suitable physical and mechanical guidance and suitable biological microenvironment are the key factors to promote the restoration of damaged nerves to biological functions such as sensation and movement. At present, more researches on nerve guides are using model casting method, electrostatic nano-spinning method, 3D bioprinting and other technologies, and using biodegradable materials such as silk fibroin, chitosan and collagen to make physical guides. Hollow catheters, but...

AI Technical Summary

Problems solved by technology

[0004] The common techniques used to prepare nerve conduits are: (1) casting-dipping method, although this method is easy to operate, but it is easy to leave toxic solvents on the scaffold, and it is difficult to control the size and distribution of holes; (2) traditional electrospinning technology, Nanofibers with high porosity and specific surface area can be formed to create a microenvironment similar to the network structure of extracellular matrix, which is conducive to nerve regeneration. However, the mechanical strength of the nerve guide produced by traditional electrospinning is not enough to repair the damaged nerve. Provide a stable mechanical environment; (3) Braiding technology, which uses a spindle braiding machine to weave the yarn into a tubular fabric, which can increase the surface area inside the catheter and has better mechanical properties

However, there are still deficiencies in inducing directional cell migration and tissue regeneration

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