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Folium ginkgo drop pill type placebo and preparation method thereof

A technology of placebo and ginkgo biloba, applied in the field of pharmacy, can solve problems such as articles that have not been developed with placebo, and achieve the effect of good simulation effect, no significant difference, and qualified quality.

Inactive Publication Date: 2019-03-26
ZHEJIANG WANBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In addition, there is no article on the development of the corresponding dosage form placebo for drop pills as a traditional Chinese medicine form, which is still a vacancy

Method used

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  • Folium ginkgo drop pill type placebo and preparation method thereof
  • Folium ginkgo drop pill type placebo and preparation method thereof
  • Folium ginkgo drop pill type placebo and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] The parts by weight of the raw materials of the drop pill Chinese medicine preparation placebo are: 12.7 parts of povidone-K30, 2.1 parts of caramel, 1.2 parts of sucrose octaacetate, and 44.0 parts of polyethylene glycol-4000.

[0064] The preparation method of making the above-mentioned components into the placebo of the drop pill Chinese medicine preparation of the present invention is: take polyethylene glycol-4000 according to the above-mentioned formula ratio and heat and dissolve to melt, and then add the sucrose octaacetate of the above-mentioned formula ratio successively , caramel, povidone-K30, stir well. Transfer the melted medicinal solution to a dropping pill machine for dripping to obtain plain pills, wash, sieve and air-dry the pills, coat them with film, and pack them.

Embodiment 2

[0066] The parts by weight of the raw materials of the dropping pill Chinese medicine preparation placebo are: 13.3 parts of povidone-K30, 2.1 parts of caramel, 0.6 parts of sucrose octaacetate, and 44.0 parts of polyethylene glycol-4000.

[0067] The preparation method of this embodiment is consistent with that of Example 1 except that the components added to each raw material are different.

Embodiment 3

[0069] The parts by weight of the raw materials of the drop pill Chinese medicine preparation placebo are: 13.6 parts of povidone-K30, 1.2 parts of caramel, 1.2 parts of sucrose octaacetate, and 44.0 parts of polyethylene glycol-4000.

[0070] The preparation method of this embodiment is consistent with that of Example 1 except that the components added to each raw material are different.

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Abstract

The invention discloses a folium ginkgo drop pill type placebo and a preparation method thereof. The placebo is prepared from a filling agent, a flavoring agent, a coloring agent and a matrix. The placebo has the advantage that the appearance, color, odor and taste and the like of the placebo are similar to the appearance, color, odor and taste and the like of the testing medicine, and the easiness in distinguishing by a studying person and a tested person is avoided, so that the deviation or unblinding in the clinical test can be effectively prevented, and the smooth implementing of the clinical test is guaranteed.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a placebo for ginkgo leaf dripping pills and a preparation method thereof. Background technique [0002] Placebo refers to a class of pharmaceutical preparations that have no therapeutic effect, but have a substitute and comforting effect on people who have long-term use of certain drugs that have adverse consequences. The placebo acts as an analgesic or relieves symptoms due to the patient's trust in the doctor, the patient's self-suggestion, or the patient's expectation on the efficacy of a certain drug. Since the development of modern medicine, with the popularization of evidence-based medicine, in drug clinical trial research, researchers are increasingly using placebo as a control to verify the therapeutic effect of experimental drugs. [0003] Single-case randomized controlled trials (N-of-1), as a clinical curative effect evaluation method that conforms to the individual rules and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCA61K49/0004
Inventor 杨韬炜邓胜红陈莉张瑶丹许海军
Owner ZHEJIANG WANBANG PHARMA
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