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A kind of cocktail method two-color freeze-dried powder and preparation method thereof

A technology for freeze-dried powder and cocktail, which is applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of incomplete effect, increased dosage of excipients, poor vision, etc. The effect of long-term storage and long storage time

Active Publication Date: 2022-02-11
广州常青藤化妆品有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The lyophilized powder currently on the market has the following disadvantages: (1) due to the simple added functional ingredients, the effect is not durable; (2) due to the simple added functional ingredients, the effect is not comprehensive; (3) due to the single color of the powder, poor vision
In the actual production of freeze-dried powder, each polypeptide is added as a raw material to the formulation of the freeze-dried powder. Some peptides are pure products, and some are a mixture containing stabilizers. Mix all the raw materials in a The solution will make the formulation and lyophilization process test work complicated and time-consuming and increase the amount of excipients

Method used

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  • A kind of cocktail method two-color freeze-dried powder and preparation method thereof
  • A kind of cocktail method two-color freeze-dried powder and preparation method thereof
  • A kind of cocktail method two-color freeze-dried powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0031] See Table 1 for the raw material formula of the cocktail method double-color freeze-dried powder described in Examples 1-3, see Table 2 for the raw material formula of excipient A, and see Table 3 for the raw material formula of excipient B.

[0032] The preparation method of the cocktail method double-color freeze-dried powder described in Examples 1-3 comprises the following steps:

[0033] (1), the raw materials of the upper layer freeze-dried powder and the lower layer freeze-dried powder are respectively prepared into an upper layer freeze-dried powder solution and a lower layer freeze-dried powder solution;

[0034] (2), the lower layer of freeze-dried powder solution is first injected into the packaging bottle, and then the upper layer of freeze-dried powder solution is injected into the packaging bottle for freeze-drying treatment:

[0035] a. Lower the temperature to -44°C and keep it for 10 minutes;

[0036] b. Heat up to -35°C within 20 minutes, and keep at ...

Embodiment 4

[0053] The freeze-dried powders prepared in Examples 1-3 and Comparative Example were placed for 0, 6 months and 12 months respectively, dissolved in water, and the time required for complete dissolution was tested. The test results are shown in Table 4.

[0054] The dissolving time of the lyophilized powder that table 4 embodiment 1~3 and comparative example make

[0055]

[0056] As can be seen from the results in Table 4, the lyophilized powder described in Examples 1 to 3 can still be dissolved in water quickly after being placed for 12 months, while the lyophilized powder described in the comparative example needs to be dissolved in water after being placed for 12 months. It takes a long time to completely dissolve, indicating that the formula of the two-color freeze-dried powder of the present invention is more stable and can be stored for a long time.

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Abstract

The invention discloses a cocktail method two-color lyophilized powder, which comprises an upper layer lyophilized powder and a lower layer lyophilized powder; the upper layer lyophilized powder contains oligopeptide-1, oligopeptide-3 and excipient A; the lower layer lyophilized powder The dry powder comprises tripeptide-1 copper, carnosine and excipient B; the specific gravity of excipient A is smaller than that of excipient B. The freeze-dried powder of the present invention is suitable to be stored in different systems by adding components with different functions. More functional additives can be added to the two systems. The functional additives between different systems are not easy to interact before freeze-drying, and are more stable after freeze-drying. For long-term storage, it can be re-dissolved with a solvent to form a system when used. According to the molecular weight distribution of the functional ingredients, it also presents a cocktail-like ladder distribution from low to high. Small molecules are absorbed first to take effect, and large molecules are absorbed later. effect, so that the freeze-dried powder has a faster onset and a longer lasting effect. The invention also discloses a preparation method of the cocktail method double-color freeze-dried powder.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a cocktail method double-color freeze-dried powder and a preparation method thereof. Background technique [0002] At present, there are nearly 30 freeze-dried powder manufacturers in China, and their freeze-dried powder products simply add one or two functional ingredients, and the powders are all of a single color (white or colored). The lyophilized powder currently on the market has the following disadvantages: (1) due to the simple added functional components, the effect is not durable; (2) due to the simple added functional components, the effect is not comprehensive; (3) due to the single color of the powder, poor vision . [0003] Polypeptide freeze-dried powder is a new skin care product developed in recent years, which is safe and effective. Its production method can be simply described as: filling the prepared aqueous solution into a vial and other conta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/73A61K8/64A61K8/60A61K8/34A61K8/24A61K8/02A61Q19/00
CPCA61Q19/00A61K8/022A61K8/24A61K8/345A61K8/60A61K8/64A61K8/73A61K8/735A61K2800/84
Inventor 陈同新
Owner 广州常青藤化妆品有限公司
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