Bacteriostatic hydrocolloid dressing and preparation method thereof

Abstract

The invention belongs to the technical field of hydrocolloid dressings, and particularly relates to a bacteriostatic hydrocolloid dressing and a preparation method thereof. The bacteriostatic hydrocolloid dressing comprises the following raw materials in parts by weight: 25-35 parts of sodium carboxymethylcellulose, 20-30 parts of carboxymethyl chitosan, 5-10 parts of gelatin, 20-30 parts of athermoplastic elastomer, 3-10 parts of a tackifying resin and 0.5-1.5 parts of a bacteriostatic agent. The hydrocolloid dressing adopts triclocarban and sodium ferulate as the bacteriostatic agent, the triclocarban and the sodium ferulate synergistically interact to reduce the use amount of the triclocarban and make the bacteriostatic effect remarkable, so that the hydrocolloid dressing has favorableliquid absorption and wound healing promotion ability, is safe, free of toxic and side effects and suitable for popularization and application.

Description

technical field [0001] The invention belongs to the technical field of hydrocolloid dressings, and in particular relates to a bacteriostatic hydrocolloid dressing and a preparation method thereof. Background technique [0002] Hydrocolloid dressing is a new type of medical dressing, which has the advantages of waterproof, anti-adhesion, moisturizing and heat preservation. Hydrocolloid dressing is made by mixing water-absorbing polymer particles with hot-melt pressure-sensitive adhesive. This dressing combines The adhesive properties of rubber materials and the water absorption properties of water-absorbing polymer materials, in which the rubber base material provides stickiness, enabling the dressing to stick to the wound surface, while the hydrocolloid particles dispersed in it swell after absorbing water, providing a moist seal to the wound Environment, promote wound healing, moist environment plays an important role in promoting wound healing, and brings great convenience...

AI Technical Summary

Problems solved by technology

For example, Chinese patent document CN 102218155 A discloses a preparation method of nano-silver functional hydrocolloid medical dressing, by adding nano-silver or nano-silver dispersion into the hydrocolloid, giving the hydrocolloid antibacterial function, but the medical dressing Due to the long-term use of nano-silver or nano-silver dispersion, it will cause certain cytotoxicity and harm to the human body.

On the other hand, some bacteriostatic agents such as triclocarban are a broad-spectrum and highly effective new antibacterial agent, which have been recognized for their high bactericidal rate, non-irritating skin, non-allergic and good compatibility with the skin. Widely used, but studies have shown that long-term heavy use can cause liver and kidney damage and affect the immune system

For example, Chinese patent document CN 107982571A discloses a hydrocolloid dressing with strong antibacterial ability and its preparation method, including the following preparation raw materials: sodium carboxymethyl cellulose, carboxymethyl chitosan, polyurethane thermoplastic elastomer, seaweed Sodium phosphate, tackifying resin, plasticizer, gelatin, alkyl starch ester, polyisobutylene, antioxidant, bacteriostat and synergistic bacteriostat, which have good antibacterial properties, but the composition is complex, and the main antibacterial components are three Long-term use of clocarban can cause liver and kidney damage and affect the immune system, so its dosage should be controlled reasonably while ensuring the antibacterial effect

[0005] Therefore, based on the current hydrocolloid dressings facing complex wounds, there are generally problems such as poor liquid absorption performance, side effects on the human body caused by the addition of antibacterial agents, and complex components. It is necessary to provide people with a simple composition, liquid absorption and wound healing Hydrocolloid dressing with good antibacterial properties, safety and no side effects and preparation method thereof

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