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Bone cement with biological activity and antibacterial function and preparation method thereof

A bioactive bone cement technology, applied in the fields of materials science and medicine, can solve the problems of affecting the mechanical properties of bone cement, affecting the release rate of antibiotics, and toxic side effects, so as to speed up the bone growth process and reduce the risk of re-operation revision. The effect of clinical application value

Active Publication Date: 2019-03-15
上海朗迈医疗器械科技有限公司
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, such products have problems such as antibiotic toxicity and bacterial resistance. At the same time, different antibiotics and their different doses not only affect the release rate of antibiotics, but also affect the mechanical properties of bone cement.
Metal ions represented by silver and copper have good antibacterial effect and avoid the problem of bacterial drug resistance, but the accumulation of free metal ions in the body to a certain extent will produce a series of toxic side effects

Method used

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  • Bone cement with biological activity and antibacterial function and preparation method thereof
  • Bone cement with biological activity and antibacterial function and preparation method thereof
  • Bone cement with biological activity and antibacterial function and preparation method thereof

Examples

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preparation example Construction

[0040] The preparation method of the bone cement with biological activity and antibacterial effect comprises the following steps:

[0041](1) Preparation of antibacterial bioglass:

[0042] a. In terms of mass percentage, the method of modifying 0.05-5wt% silane coupling agent is introduced into functional groups on the surface of 95-99.95wt% bioglass;

[0043] b. In terms of mass percentage, 95-99.95wt% of the surface-modified bioglass and 0.05-5wt% of metal ions with antibacterial function are anchored through a complexation reaction;

[0044] (2) Preparation of acrylate bone cement with bioactivity and antibacterial function:

[0045] a. In terms of mass percentage, mix 59.5-99.5wt% powdered acrylate polymer, 0.5-2wt% initiator, 5-20wt% antibacterial bioglass, 10-50wt% developer, and sterilize Process to obtain the powder part of the bone cement with biological activity and antibacterial effect;

[0046] b. In terms of volume percentage, mix 95-99.9vol% of acrylate monom...

Embodiment 1

[0058] This example involves the preparation of antibacterial biological glass powder.

[0059] Disperse 9.95g of bioglass powder 45S5 into 100mL of ethanol solution, add 0.05g of silane coupling agent KH-550 after the dispersion is uniform, heat in a water bath at 60°C and stir at 100rpm for 6 hours, then suction filter and dry in an oven at 37°C; take the above steps Disperse 9.95g of the powder in 200mL ethanol solution, add 10mL 0.5wt% silver nitrate aqueous solution after dispersing evenly, stir at room temperature at 80rpm for 2 hours, then filter with suction and dry in an oven at 37°C. The glass powder is prepared.

Embodiment 2

[0061] This example involves the preparation of antibacterial biological glass powder.

[0062] Disperse 9.5g of bioglass ceravital powder into 100mL of methanol solution, add 0.5g of silane coupling agent KH-540 after the dispersion is uniform, heat in a water bath at 60°C and stir at 100rpm for 6 hours, then suction filter and dry in an oven at 37°C; take the above steps Disperse 9.5g of the powder in 200mL ethanol solution, add 10mL 5wt% silver acetate aqueous solution after dispersing evenly, stir at room temperature at 80rpm for 2 hours, then filter with suction and dry in an oven at 37°C. Powder preparation is complete.

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Abstract

The invention discloses bone cement with biological activity and antibacterial function and a preparation method thereof and belongs to the field of material science and medicine. After modification treatment, biological glass is mixed with an acrylate bone cement matrix material, so that the bone cement is endowed with the biological activity and the antibacterial function. The surface of the biological glass is rich in amino through chemical treatment, and further silver, copper and other ions are compounded, so that the biological glass with the antibacterial metal ions on the surface is formed. The biological glass not only has the antibacterial function, but also can avoid the risks of circulation and accumulation of the metal ions in a human body. The antibacterial biological glass is added in the acrylate bone cement and can realize a long-term antibacterial effect in an implantation position. The bone cement prepared by the preparation method can reduce the risk of revision caused by infection after the bone cement is implanted in a patient, solve the problem of human body drug resistance caused by the current clinical application of antibiotic bone cement and can be used in the orthopaedic field such as joint and spine repair, thereby having a broad clinical application prospect.

Description

technical field [0001] The invention belongs to the field of material science and medicine, more specifically, the invention relates to a preparation method and application of an acrylate bone cement with biological activity and antibacterial function. Background technique [0002] Diseases, trauma, population aging and natural disasters will all lead to damage to human bone tissue, and there is a huge demand for bone repair materials in clinical practice. Artificially prepared bone repair materials have received more and more attention clinically. The traditional acrylate bone cement represented by polymethyl methacrylate (PMMA) is a room temperature self-curing adhesive composed of powder and liquid. This type of product has the advantages of good fluidity, strong operability for injectable implantation, good mechanical properties after implantation, and controllable curing time, etc., and its clinical application is developing rapidly. At present, there are at least 40 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/02A61L27/10A61L27/12A61L27/50A61L27/54
CPCA61L27/025A61L27/10A61L27/12A61L27/16A61L27/50A61L27/54A61L2300/104A61L2300/102A61L2300/404A61L2430/02C08L33/08
Inventor 周华溢陈政保何敏郝刘男倪文龙
Owner 上海朗迈医疗器械科技有限公司
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