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Occluder and its preparation method

An occluder and occluder disc technology, applied in medical science, surgery, etc., can solve the problems of thrombus falling off, easy thrombus formation, thromboembolism, etc.

Active Publication Date: 2022-06-07
LIFETECH SCI (SHENZHEN) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the use of the occluder, when the heart defect occluder comes into contact with blood, thrombus is easily formed on the surface of the occluder, and the formed thrombus may fall off the device, causing problems such as thromboembolism

Method used

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  • Occluder and its preparation method
  • Occluder and its preparation method
  • Occluder and its preparation method

Examples

Experimental program
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Effect test

preparation example Construction

[0064] The preparation method of the occluder of one embodiment, comprises the following steps:

[0065] Step 110: Provide support mesh.

[0066] The support mesh can be formed by weaving braided wire, or by means of pipe cutting, injection molding, and the like.

[0067] It should be noted that, after the supporting mesh is formed, the following step 120 may be performed after further shaping the supporting mesh. Further, if the occluder further includes a flow blocking film, the flow blocking film can also be fixed in the support net before performing the following step 120 .

[0068] Step 120 : forming an anti-thrombotic film on the support mesh by means of leaching and / or spraying, wherein the anti-thrombotic film includes an endothelialization-promoting film; the endothelialization-promoting film includes a degradable polymer and is dispersed in the degradable polymer or the endothelialization-promoting film contains the endothelialization-promoting material, and the an...

Embodiment 1

[0081] A support net formed by weaving nickel-titanium alloy wires is provided, and the support net is shaped to form a structure including two blocking discs and a waist portion, which are large at both ends and small in the middle.

[0082] Dissolving racemic polylactic acid in ethyl acetate to prepare a saturated racemic polylactic acid solution; dissolving phosphatidylcholine in ethanol to prepare a saturated phosphatidylcholine solution; dissolving the racemic polylactic acid The solution and the phosphatidylcholine solution are mixed in a volume ratio of 9:1 to obtain a mixed solution. Wherein, the weight average molecular weight of racemic polylactic acid is 30w.

[0083] The shaped support net is completely immersed in the above mixed solution, and taken out after 10 seconds. After the solvent is volatilized, an antithrombotic film is formed on the surface of the support net to obtain an occluder. The antithrombotic membrane is a continuous film, the antithrombotic me...

Embodiment 2

[0086] Provide a support net woven from polydioxanone woven silk, and shape the support net to form a structure with two large ends and a small middle, including two blocking discs and a waist, respectively. One waist suture material is a flow blocking film of polydioxanone.

[0087] Dissolving racemic polylactic acid in ethyl acetate to prepare a solution of racemic polylactic acid with a concentration of 10 mg / mL; dissolving phosphatidylcholine in ethanol to prepare a phosphatidylcholine concentration of 20 mg / mL solution; the racemic polylactic acid solution and the phosphatidylcholine solution are mixed in a volume ratio of 9:1 to obtain a mixed solution. The weight-average molecular weight of the racemic polylactic acid was 1,000.

[0088] A blocking disk of the above-mentioned shaped support net is completely immersed in the above-mentioned mixed solution, taken out after 10 seconds, and the solvent retained on the support net is blown away with cold air, and an antithr...

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Abstract

The invention relates to an occluder and a preparation method thereof. The occluder includes a supporting net, and the surface of the supporting net is coated with an antithrombotic film, and the antithrombotic film includes an endothelialization promoting film; the endothelializing promoting film contains a degradable polymer and an endothelializing substance dispersed in the degradable polymer. Alternatively, the endothelialization-promoting membrane contains endothelialization-promoting substances, and the antithrombotic membrane further includes a controlled-release membrane covering the endothelialization-promoting membrane, and the controlled-release membrane contains degradable polymers. The occluder can reduce or avoid thrombus formation.

Description

technical field [0001] The invention relates to the field of interventional medical devices, in particular to an occluder and a preparation method thereof. Background technique [0002] Percutaneous interventional technology is a very fast-developing disease treatment method in recent years, and the application field of this technology is becoming more and more extensive. Among them, the catheter intervention method can be used to deliver various instruments and drugs to the heart, arteriovenous blood vessels and other parts of the human body. Wherein, the device may be an occluder, a vascular plug, a vascular filter, and the like. [0003] Among them, the occluder can be used for minimally invasive treatment of congenital heart disease such as atrial septal defect, ventricular septal defect, patent ductus arteriosus and patent foramen ovale. However, during the use of the occluder, when the cardiac defect occluder is in contact with blood, a thrombus is easily formed on t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B17/00
CPCA61B17/0057A61B2017/00831A61B2017/00004A61B2017/00654A61B2017/00606A61B2017/00601A61B2017/00597
Inventor 褚华磊
Owner LIFETECH SCI (SHENZHEN) CO LTD
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