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Anti-tumor combination drug

An anti-tumor drug and anti-tumor technology, applied in anti-tumor drugs, drug combinations, active ingredients of heterocyclic compounds, etc.

Active Publication Date: 2019-03-12
CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the combination of daphnetin and chemotherapy drugs to treat tumors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, the influence of daphnetin on IDO1 enzyme activity

[0025] 1 Experimental materials

[0026] 1.1 Cells and plasmids

[0027] Human cervical cancer cells HeLa and human embryonic kidney cells HEK-293A were purchased from the Cell Resource Center of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and preserved by the Natural Products Center Laboratory of Chengdu Institute of Biology, Chinese Academy of Sciences; IDO cDNA was purchased from Beijing Yiqiao Shenzhou Technology Co., Ltd.

[0028] 1.2 Reagents

[0029] Daphnetin was purchased from Shanghai Yuanye Biotechnology Co., Ltd.; Epacadostat was purchased from Shanghai Bluewood Chemical Co., Ltd.; human interferon IFN-γ was purchased from Nanjing GenScript Biotechnology Co., Ltd.; IDO1 rabbit polyclonal antibody, GAPDH rabbit polyclonal antibody Antibody was purchased from Wuhan Sanying Biotechnology Co., Ltd.; transfection reagent LIPOFECTAMINE 2000 was purchased from Thermo F...

Embodiment 2

[0054] Embodiment 2, the experiment of daphnetin and antitumor drug combined use

[0055] 1 Experimental materials

[0056] 1.1 Cells and Animals

[0057] Human breast cancer cell lines MCF-7 and MDA-MB-231 were donated by Dr. Cowan of the National Cancer Institute of the United States and preserved by the Natural Products Center Laboratory of Chengdu Institute of Biology, Chinese Academy of Sciences; SPF-grade ICR healthy female mice, weighing 18-22g , purchased from Chengdu Dashuo Experimental Animal Co., Ltd., license number: SYXK (Sichuan) 2018-189.

[0058] 1.2 Drugs and reagents

[0059] The enhanced CCK-8 kit was purchased from Shanghai Biyuntian Biotechnology Co., Ltd.; Daphnetin was purchased from Shanghai Yuanye Biotechnology Co., Ltd.; human interferon IFN-γ was purchased from Nanjing GenScript Biotechnology Co., Ltd.; Cyclophosphamide (CTX) was purchased from Sigma, USA; Doxorubicin (Dox) injection was purchased from Shanghai Xudong Haipu Pharmaceutical Co., Ltd...

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PUM

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Abstract

The invention provides an anti-tumor pharmaceutical composition and combination drug. The drug is formed by daphnetin and an anti-tumor drug according to a certain ratio. Experiment results prove thatafter the daphnetin is used with other anti-tumor drugs, a remarkable anti-tumor effect is achieved.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to an antitumor combined medicine. Background technique [0002] Malignant tumors are currently the main killer of human health and one of the most important diseases that seriously threaten human life. The comprehensive treatment of tumors mainly includes surgery, radiation therapy and tumor chemotherapy. Drugs play an important role in chemotherapy of malignant tumors. In recent years, the research and development of anticancer drugs has made great progress in tumor chemotherapy. The application of drugs such as carboplatin and paclitaxel in the last century has made some specific tumors have a high cure rate. However, due to the poor selectivity of anti-tumor drugs, large toxic and side effects, drug resistance and other defects, more than half of tumor patients still have no response or drug resistance to treatment, which eventually leads to treatment failure, especially t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61K31/337A61K31/675A61K31/704A61K33/24A61P35/00
CPCA61K31/337A61K31/37A61K31/675A61K31/704A61K33/24A61P35/00A61K2300/00
Inventor 王飞张国林李晟周宗元艾曼纽·莫福蒂付乃洁黎玥佳
Owner CHENGDU INST OF BIOLOGY CHINESE ACAD OF S
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