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Traditional Chinese medicine composition for alleviating extrapyramidal side effects of antipsychotics and application thereof

An antipsychotic drug and extrapyramidal system technology, which is applied in the direction of drug combination, nervous system diseases, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2019-03-08
SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report about the traditional Chinese medicine composition of the present invention for improving extrapyramidal side effects caused by antipsychotic drugs

Method used

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  • Traditional Chinese medicine composition for alleviating extrapyramidal side effects of antipsychotics and application thereof
  • Traditional Chinese medicine composition for alleviating extrapyramidal side effects of antipsychotics and application thereof
  • Traditional Chinese medicine composition for alleviating extrapyramidal side effects of antipsychotics and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 Improves the Chinese medicine composition (1) of extrapyramidal side effects caused by antipsychotic drugs

[0030] Take the raw materials of traditional Chinese medicine: 9 parts of Gastrodia elata, 12 parts of Uncaria, 12 parts of Cassia Lithops, 9 parts of Rhizoma chinensis, 12 parts of Achyranthes bidentata, 9 parts of Eucommia ulmoides, 12 parts of Rehmannia glutinosa, 9 parts of paeonol, and decoct according to the conventional method.

Embodiment 2

[0031] Embodiment 2 Improves the Chinese medicine composition (two) of extrapyramidal side effects caused by antipsychotic drugs

[0032] Take the raw materials of traditional Chinese medicine: 6 parts of Gastrodia elata, 15 parts of Uncaria, 9 parts of Cassia Lithops, 12 parts of Shanmao, 9 parts of Achyranthes bidentata, 12 parts of Eucommia ulmoides, 9 parts of rehmannia glutinosa, and 12 parts of paeonol, and decoct according to the conventional method.

Embodiment 3

[0033] Example 3 Chinese medicine composition for improving extrapyramidal side effects caused by antipsychotic drugs (three)

[0034] Take traditional Chinese medicine raw materials: 12 parts of Gastrodia elata, 9 parts of Uncaria, 15 parts of Cassia Lithops, 6 parts of Rhizome, 15 parts of Achyranthes bidentata, 6 parts of Eucommia ulmoides, 15 parts of rehmannia glutinosa, 6 parts of paeonol, and decoct according to the conventional method.

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Abstract

The invention relates to the technical field of traditional Chinese medicines, and specifically discloses a traditional Chinese medicine composition for alleviating extrapyramidal side effectsof antipsychotics and application thereof. The traditional Chinese medicine composition is prepared from the following crude drugs in parts by weight: 6-12 parts of rhizoma gastrodiae, 9-15 parts of ramulus uncariae cum uncis, 9-15 parts of raw concha haliotidis, 6-12 parts of fructus gardeniae, 9-15 parts of radix cyathulae, 6-12 parts of cortex eucommiae, 9-15 parts of radix rehmanniae preparata and 6-12 parts of cortex moutan. Clinical tests prove that the traditional Chinese medicine composition disclosed by the invention in combination with aripiprazole has an effect of alleviating mental symptoms and extrapyramidal side effects of a patient, and the effect is equivalent to that of a combination of the aripiprazole and artane; and drug side effects are fewer. The application of the traditional Chinese medicine composition disclosed by the invention can improve drug use safety and effectiveness of the antipsychotics, and has a relatively good application prospect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for improving extrapyramidal side effects caused by antipsychotic drugs and its application. Background technique [0002] Antipsychotic drugs often have extrapyramidal side effects during treatment, and the OR value of extrapyramidal side effects caused by taking aripiprazole is 1.20 (0.73-1.85) [Document: Baris Olten, Michael H.Bloch. Metaregression : Relationship between antipsychotic receptor binding profiles and side-effects[J].Progress in Neuro-Psychopharmacology and Biological Psychiatry,2018,84(8):272-281], extrapyramidal side effects mainly include Parkinson-like reaction, akathisia, acute Different manifestations such as dystonia and tardive dyskinesia, and extrapyramidal side effects have a significant impact on the quality of life, social function and medication compliance of patients. Existing drugs to...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61P25/00A61P25/18A61K31/496
CPCA61K31/496A61K35/618A61K36/21A61K36/46A61K36/65A61K36/71A61K36/74A61K36/744A61K36/804A61K36/8988A61K2236/331A61K2236/39A61P25/00A61P25/18A61K2300/00
Inventor 朱丽萍龙彬张建明陆颖赵静陈妍朱玉华吴海苏琚明亮
Owner SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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