Method for quantifying interactive effect of continuous blood pressure signals and physiological signals

Abstract

The invention belongs to the field of medical monitoring, and discloses a method for quantifying the interactive effect of continuous blood pressure signals and physiological signals. The method comprises the following steps of correcting a linear relation model of blood pressure and pulse wave conduction time; synchronously and continuously collecting pulse wave signals and sleeping physiologicalsignals under the sleep state; according to the corrected linear relation model of blood pressure and pulse wave conduction time, obtaining a normal breathing section and a continuous blood pressurevalue including the one-time apnea section; according to a transmission entropy calculation formula, calculating transmission entropy of sleeping physiological signals to blood pressure of the normalbreathing section and the one-time apnea section, wherein the transmission entropy is used for quantifying the interactive effect of continuous blood pressure signals and physiological signals, and therefore the purpose of accurately quantifying the interactive effect of continuous blood pressure signals and physiological signals is achieved.

Description

technical field [0001] The invention relates to the field of medical monitoring, in particular to a method for quantifying the interaction between continuous blood pressure signals and physiological signals. Background technique [0002] Sleep apnea-hypopnea syndrome (SAHS) is a sleep disorder in which breathing stops during sleep. The most common cause is collapse or obstruction of the upper airway. The clinical manifestations are mainly sleep snoring, waking up, napping during the day, fatigue, etc. This disease is likely to cause hypoxia and hypercapnia in human body functions. Cause hypertension, diabetes and cardiovascular and cerebrovascular diseases. According to epidemiological data, SAHS is related to high blood pressure. According to foreign reports, 45% to 48% of SAHS patients suffer from high blood pressure. In 2006, a survey conducted by the Sleep Respiratory Diseases Group of the Chinese Medical Respiratory Society showed that the prevalence of hypertension i...

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Problems solved by technology

Patients with high blood pressure caused by SAHS are prone to missed diagnosis and delayed treatment due to their hidden condition. They often go to the doctor only when they find high blood pressure, which misses the best time and adds a lot of difficulty to treatment.

[0003] At present, the most authoritative method for diagnosing SAHS is polysomnography (PSG). This technology is very mature and common. A variety of sleep physiological parameters including saturation and EEG are available for clinicians to analyze and diagnose, but cannot continuously measure blood pressure

At present, the most common method is to measure the blood pressure before the sleep monitoring and after the subjects wake up, which can only serve as a comparison and reference, and it is impossible to discuss sleep apnea-hypopnea syndrome and blood pressure from the quantitative indicators obtained from sleep monitoring. The relationship between continuous changes

It is also possible to synchronize 24-hour ambulatory blood pressure monitoring through polysomnography, but the arterial blood pressure is measured through repeated inflation of the cuff, which will inevitably affect the normal sleep pattern of the subject, and the cuff inflation measurement is also based on a certain time interval (such as : half an hour), rather than continuous uninterrupted monitoring

Due to objective reasons such as monitoring methods and individual differences, the research results on the relationship between sleep physiological parameters and blood pressure changes are still unsatisfactory

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