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Method for detecting a trace amount of carbadox by using mesoporous carbon CMK-8 direct electrochemical sensor with cubic Ia3d structure

A mesoporous carbon, electrochemical technology, applied in the direction of material electrochemical variables, measuring devices, scientific instruments, etc., can solve the problems of high requirements for detection instruments, high sensitivity, complex steps, etc., to achieve easy automation of detection and improved sensitivity. Effect

Active Publication Date: 2019-02-22
ZHAOQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The most commonly used method is liquid chromatography-tandem mass spectrometry, but this method is relatively complicated in the processing of actual samples, and has high requirements for detection instruments, which is not simple enough
Electrochemical detection is efficient, fast, high selectivity, high sensitivity, relatively low requirements for instruments, and is widely used in various detections, but there are few literature reports on electrochemical determination of carbadox

Method used

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  • Method for detecting a trace amount of carbadox by using mesoporous carbon CMK-8 direct electrochemical sensor with cubic Ia3d structure
  • Method for detecting a trace amount of carbadox by using mesoporous carbon CMK-8 direct electrochemical sensor with cubic Ia3d structure
  • Method for detecting a trace amount of carbadox by using mesoporous carbon CMK-8 direct electrochemical sensor with cubic Ia3d structure

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Experimental program
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Effect test

Embodiment 1

[0026] Embodiment 1: Construction of the electrochemical sensor for detecting trace carbad oxygen according to the present invention

[0027] A kind of method of direct electrochemical sensor detection trace carbadoxy with cubic Ia3d structure mesoporous carbon CMK-8 of the present invention comprises the following steps:

[0028] (1) Treatment of gold electrodes:

[0029] Rinse the gold electrode (Φ=3mm) with deionized water twice, then polish it with 0.05 μm γ-alumina polishing powder, wash it again, and dry it for later use;

[0030] (2) Preparation of cubic Ia3d structured mesoporous carbon CMK-8 dispersion:

[0031] Accurately weigh a certain amount of cubic Ia3d structure mesoporous carbon CMK-8 powder, disperse it with DMF, and sonicate for 1 h to obtain a uniformly dispersed 4 mg / mL mesoporous carbon dispersion.

[0032] (3) Mesoporous carbon CMK-8 modified electrode with cubic Ia3d structure:

[0033] Take an appropriate amount of cubic Ia3d structured mesoporous c...

Embodiment 2

[0038] Example 2: Differential pulse voltammetry characterization of the electrochemical sensor used to detect trace amounts of carbadox according to the present invention

[0039] Differential pulse voltammetry was used to observe the electrochemical reaction of carbadox on bare electrode and cubic Ia3d structure mesoporous carbon CMK-8 modified electrode. Such as figure 1 As shown, on the bare electrode (curve a), the peak current of 2 μM carbadox is 0.46 μA, while under the modification of cubic Ia3d structure mesoporous carbon CMK-8 (curve b), the peak current can reach 233.4 μA ( Curve a), compared with the bare electrode, has a peak current increase of 507 times. And by figure 2 It can be clearly seen that the baseline of curve b is significantly lower than the baseline of curve a, which shows that CMK-8 has a huge specific surface area and can effectively increase the signal.

Embodiment 3

[0040] Embodiment 3: linear range and detection limit experiment

[0041] Based on the strong electrocatalytic effect of the cubic Ia3d structured mesoporous carbon CMK-8 modified electrode on the electroreduction of carbad oxygen, an ultrasensitive electrochemical detection method for carbad oxygen can be established. When carbad oxygen is in the concentration range of 0.1nM to 500.0nM, the electrochemical signal response has a good linear relationship with the concentration of carbad oxygen (see figure 2), its linear regression equation is -I(μA)=0.503×C(nmol / L)-0.128, R=0.997, and the detection limit is 74.4pM. The invention significantly improves the sensitivity of carbadox detection, and is easy to automate the detection of low-concentration carbadox.

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Abstract

The invention relates to a method for detecting a trace amount of carbadox by using a mesoporous carbon CMK-8 direct electrochemical sensor with a cubic Ia3d structure. A CMK-8 modified glassy carbonelectrode with a cubic Ia3d structure is adopted, the established sensor is used for direct determination of the carbadox. When the carbadox is in a concnetartion range of 0.5-500.0 nM, the electrochemical signal response and carbadox concentration show good linear relation, and the detection limit of the method is 74.4 pM. By adopting the method, the sensitivity of carbadox detection is remarkably improved, and the detection of low-concentration carbadox is automatic.

Description

technical field [0001] The invention belongs to the technical field of novel functional materials and electrochemical sensing and detection, and relates to a method for detecting trace amounts of carbadoxine, in particular to a method for directly detecting trace amounts of carbadoxine with a cubic Ia3d structure mesoporous carbon CMK-8 electrochemical sensor method. Background technique [0002] Carbadox (CBX) is a traditional quinoxaline drug. This type of drug is a chemically synthesized animal-specific drug. It has broad-spectrum antibacterial effects and can promote the growth and development of pigs, chickens, cattle, sheep, rabbits and other animals. , and can improve the conversion rate of feed, Carbadox is widely used in aquaculture and poultry farming such as pigs and chickens. However, many toxicology reports show that carbadox has genotoxicity, mutagenicity and carcinogenicity. If it is added to the feed, there will be obvious residues in the body after the ani...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/308G01N27/48
Inventor 刘艳清汪洪武姚夙王淑兰胡耿鑫
Owner ZHAOQING UNIV
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