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Clonidine hydrochloride sustained-release tablet and preparation method thereof

A technology of clonidine hydrochloride and sustained-release tablets, which is applied in medical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as the lack of combined application of clonidine hydrochloride and scutellarin, To achieve the effect of improving the antihypertensive effect

Active Publication Date: 2019-02-22
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no research on the combined application of clonidine hydrochloride and scutellarin in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0042] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. All percentages, ratios, proportions or parts are by weight unless otherwise indicated.

[0043] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as are familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described can be applied to the method of the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only.

[0044] The preparation of embodiment clonidine hydrochloride sl...

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PUM

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Abstract

The invention relates to a clonidine hydrochloride sustained-release tablet and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The clonidine hydrochloride sustained-release tablet is prepared from the following raw materials in parts by weight: 0.1 to -0.5 part of an active constituent, 8 to -18 parts of a composite polymer skeleton system, 10 to -18 parts of a disintegrating agent, 12 to -18 parts of a binder, 15 to -30 parts of a diluent, and 0.1 to -2 parts of a lubricant; and the active constituent is constituted by clonidine hydrochloride and scutellarin, and the composite polymer skeleton system is constituted by methylcellulose and polyvinyl alcohol. The clonidine hydrochloride and the scutellarin are jointly applied to preparation of the sustained-release tablet for depressurization for the first time, by optimizing and screening a formula, an effect experiment study finds that through joint application of the clonidine hydrochloride andthe scutellarin, the depressurization effect can be improved remarkably, and the synergistic interaction effect is achieved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a clonidine hydrochloride sustained-release tablet and a preparation method thereof. Background technique [0002] Clonidine hydrochloride is an imidazoline derivative synthesized in the early 1960s. It is an α2-adrenergic receptor agonist, which directly stimulates the central post-synaptic membrane α2 receptors in the hypothalamus and medulla medulla, and stimulates the inhibitory neurons. It can reduce the central sympathetic nerve impulse transmission, thereby inhibiting peripheral sympathetic nerve activity. Clinically, it is mainly used to treat hypertension, hypertensive emergencies, migraine, menopausal hot flashes, dysmenorrhea and withdrawal symptoms of opioid addiction. [0003] At present, the marketed preparations of clonidine hydrochloride exist in tablets, dropping pills, injections and transdermal patches. Clonidine Hydrochloride Sustained-release Table...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/7048A61K47/38A61K47/32A61P9/12A61K31/4168
CPCA61K9/2027A61K9/2054A61K31/4168A61K31/7048A61P9/12A61K2300/00
Inventor 王明刚陈阳生孙桂玉刘晓霞王清亭杜昌余刘振玉方东兵
Owner CP PHARMA QINGDAO CO LTD
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