Phenylboronic acid polymer based on amino epoxy group ring-opening polymerization and its preparation method and application

An aminophenylboronic acid and polymer technology, which is applied in the field of phenylboronic acid polymers to achieve the effects of high capacity, high affinity and specific adsorption capacity

Active Publication Date: 2020-11-13
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

No need to add any initiator in the synthetic process of the present invention

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  • Phenylboronic acid polymer based on amino epoxy group ring-opening polymerization and its preparation method and application
  • Phenylboronic acid polymer based on amino epoxy group ring-opening polymerization and its preparation method and application
  • Phenylboronic acid polymer based on amino epoxy group ring-opening polymerization and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0030] The hydrophobic phenylboronic acid polymer was prepared by amino-epoxy ring-opening polymerization, and the phenylboronic acid polymer was analyzed and characterized by scanning electron microscope, infrared characterization and nitrogen adsorption analysis. The specific operation steps are as follows:

[0031] The preparation method of phenylboronic acid polymer: dissolving m-aminophenylboronic acid (1.5%, both in mass fraction), tris(4-hydroxyphenyl)methane triglycidyl ether (10.5%) and hexamethylenediamine (3%) in In the mixed solution of dimethyl sulfoxide (25%) and polyethylene glycol 200 (60%), after ultrasonic (ultrasonic electric power 150 watts) mixing, seal in a glass bottle, and react at 60°C for 24-24.5 hours. After the polymerization reaction was completed, the polymer was taken out, ground with a mortar, and unreacted substances were removed by Soxhlet extraction for 48 hours (eluent: dimethyl sulfoxide and methanol). Finally, vacuum-dry the obtained produ...

Embodiment 2

[0039] Standard solution configuration: using methanol and water / dimethyl sulfoxide (95 / 5, volume ratio) as solvents to prepare concentrations of 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400 and 15000 μg mL -1 Sulfamethoxazole and trimethoprim solution.

[0040] Adsorption: Accurately weigh about 0.01 grams ( m ) of phenylboronic acid polymer into 10 mL centrifuge tubes, and then add 8 mL of different concentrations of sulfamethoxazole or trimethoprim standard solution to each centrifuge tube ( C i ). Shake overnight, centrifuge, and check the concentration of the supernatant by high performance liquid chromatography.

[0041] The equilibrium adsorption capacity was calculated according to the following formula ( Q e ):

[0042] Q e =8( C i - C e ) / m

[0043] Q e To balance the adsorption capacity, C i and C e is the solution concentration of sulfamethoxazole or trimethoprim before and after adsorption, m Is the mass of phenylboronic acid polymer...

Embodiment 3

[0051] Preparation of amino magnetic spheres: using 1.7 grams of FeCl 3 ·6H 2 O, add 3.3 grams of sodium acetate as a dispersant, mix well in 50 mL of ethylene glycol solution, add 10.8 grams of 1,6-hexamethylenediamine, then move the solution into a closed heating container, and carry out the solvent at 200 ° C Thermal reaction, heating time 4-4.5h, to obtain amino magnetic balls.

[0052] The preparation method of phenylboronic acid polymer-wrapped nano-magnetic beads: m-aminophenylboronic acid (1.0%, both mass fractions), tris(4-hydroxyphenyl)methane triglycidyl ether (6.0%), hexamethylenediamine ( 1%) and amino magnetic balls (2%) were dissolved in the mixed solution of dimethyl sulfoxide (30%) and polyethylene glycol 200 (60%), after ultrasonic mixing, as for the three-necked bottle, mechanically The reaction was stirred for 24-24.5 hours. After the completion of the polymerization reaction, the phenylboronic acid polymer-wrapped nano-magnetic beads were separated by a...

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Abstract

The invention relates to a phenylboronic acid polymer based on amino epoxy ring-opening polymerization as well as a preparation method and application thereof. The mass composition of raw materials ofthe phenylboronic acid polymer is 0.5-2.1% of m-amino-phenylboronic acid, 5.1-18.5% of tri(4-hydroxyphenyl)methane triglycidyl ether (or tri(4-hydroxyphenyl)methane triglycidyl ether), 0.9-3.9% of hexamethylene diamine (or 4,4'-diaminodicyclohexylmethane, or 4,4'-diaminobiphenyl), 0-2.0% of amino magnetic spheres (or other aminated solid matrix materials), 15-35% of dimethyl sulfoxide, and 45-78.5% of polyethylene glycol 200. The phenylboronic acid polymer provided by the invention is simple in preparation method, and has specific adsorption capability on hydrophobic nitrogen-containing compounds, high adsorption capacity, and wide application prospect.

Description

technical field [0001] The present invention relates to a phenylboronic acid polymer based on ring-opening polymerization of aminoepoxy group and its preparation method and application, specifically by heating and polymerizing aminophenylboronic acid, epoxy group-containing monomers and amino-containing monomers to generate phenylboronic acid polymer thing. The polymer has specific adsorption capacity for nitrogen-containing compounds, such as sulfamethoxazole and trimethoprim. Background technique [0002] The ring of the epoxy group has a strong tension, and it is easy to react with a nucleophile through a ring-opening reaction. For example, the amino-epoxy ring-opening reaction can be completed without a catalyst. The amino-epoxy ring-opening reaction can be realized by simple heating, and has been used to prepare a variety of monolithic columns, which generally have good permeability, high column efficiency, and strong separation ability. (See Liu Z., OuJ., Zou H., Tre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G79/08
CPCC08G79/08
Inventor 王涎桦董林毅彭超池帅帅
Owner TIANJIN MEDICAL UNIV
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