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Application of PARP1 inhibitor to preparation of preparation for tumor immunotherapy

A technology of immunotherapy and inhibitors, applied in the field of biomedicine, can solve problems such as stimulating immune response and side effects of the body

Active Publication Date: 2019-02-15
CARBIOGENE THERAPEUTICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From a mechanism point of view, it can not only directly kill tumors, but is also expected to stimulate the immune response of the human body and enhance the anti-tumor effect; however, the toxic and side effects of the immune cytokine storm induced by the virus are difficult to avoid and will cause side effects to the body, so looking for a A therapy that can simultaneously increase the efficacy and reduce the side effects of the virus is very important

Method used

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  • Application of PARP1 inhibitor to preparation of preparation for tumor immunotherapy
  • Application of PARP1 inhibitor to preparation of preparation for tumor immunotherapy
  • Application of PARP1 inhibitor to preparation of preparation for tumor immunotherapy

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Experimental program
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Embodiment

[0019] 1. PARP1 plays an important role in the recruitment of NK cells after virus infection in vivo

[0020] In order to determine whether PARP1 is involved in the migration of NK cells to the site of virus infection, the present invention uses the PARP1 inhibitor-AG14361. While the mice were intraperitoneally infected with VV, the mice were injected with 10 mg / kg of AG14361 into the tail vein, once a day, for 3 consecutive days. Day, 3 days after drug administration and virus infection, observe the percentage of NK cells and the total number of cells in the peritoneal cavity, and evaluate the virus clearance capacity of the peritoneal cavity at the same time. The result is as figure 1 As shown, the experiment found that PARP1 inhibitors can inhibit the migration of peritoneal NK cells and reduce the ability of virus clearance after virus infection.

[0021] 2. PARP1 inhibitor inhibits PCF inflammatory factors and chemokines after virus infection in vivo

[0022] Such as ...

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Abstract

The invention relates to the field of biomedicines, and discloses application of a PARP1 inhibitor to preparation of a preparation for tumor immunotherapy. The invention finds that the PARP1 inhibitorcan enhance the therapeutic effect of the tumor immunotherapy and reduce toxic and side effects. Specifically, (1) the PARP1 inhibitor can reduce the virus scavenging ability and can prolong the acting duration of an oncolytic virus on tumor cells so as to improve the antitumor ability of the oncolytic virus, and (2) after PARP1 inhibition, cytokines and chemokines released by macrophages can besignificantly reduced and an immune cytokine storm induced by the oncolytic virus can be reduced so as to reduce the toxic and side effects of the oncolytic virus in the tumor immunotherapy. The PARP1inhibitor has a far-reaching significance in the tumor immunotherapy.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of PARP1 inhibitors in the preparation of tumor immunotherapy preparations. Background technique [0002] Tumor immunotherapy has made a series of progress in recent years, among which oncolytic virus is one of the most attractive immunotherapies. Oncolytic virus refers to a type of virus that can effectively infect and destroy cancer cells. When infected cells rupture and die, newly formed virus particles are released and further infect surrounding cancer cells. From a mechanism point of view, it can not only directly kill tumors, but is also expected to stimulate the immune response of the human body and enhance the anti-tumor effect; however, the toxic and side effects of the immune cytokine storm induced by the virus are difficult to avoid and will cause side effects to the body, so looking for a A therapy that can simultaneously increase efficacy and reduce viral ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5517A61P35/00
CPCA61K31/5517A61P35/00
Inventor 寿旗扬杨文君其他发明人请求不公开姓名
Owner CARBIOGENE THERAPEUTICS CO LTD
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