Preparation method of skincare chloasma dispeling capsule

A technology for capsules and freckle removal, which is applied in the field of preparation of beauty-preserving and freckle-removing capsules, can solve the problems of less obvious curative effect, increased irritation, slow onset of retinoic acid, etc., and achieves the effects of shortening the onset time and improving the effective treatment efficiency.

Inactive Publication Date: 2019-02-05
青海晶珠藏药高新技术产业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydroquinone cream and retinoic acid drugs have certain effects, but there are also shortcomings: when the concentration of hydroquinone cream is high, the curative effect is improved, but the irritation is aggravated, and long-term use can lead to exogenous chloasma; It takes about half a year for the drug to gradually become effective
Jingzhu Jingtian Quban Capsules are selected from plateau medicinal materials, composed of Rhodiola rosea, astragalus, safflower, pearls, etc. It has the effects of promoting blood circulation and Qi, removing freckles and acne, and has achieved definite curative effect in the treatment of chloasma, and the patients are resistant to it. It has good acceptance, but the curative effect of some patients is not obvious after use, or the onset time is slow, so the existing formula needs to be adjusted in order to shorten the time from administration to onset of effect and improve the treatment efficiency

Method used

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  • Preparation method of skincare chloasma dispeling capsule
  • Preparation method of skincare chloasma dispeling capsule
  • Preparation method of skincare chloasma dispeling capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Weigh each component according to the following formula:

[0046]

[0047] Prepare as follows:

[0048] 1) Rhodiola, Radix Polygoni Multiflori and Angelica were reflux extracted three times with 70% ethanol aqueous solution (volume), the first time was extracted with ethanol with 6 times the volume of the medicinal material for 3 hours, and the second time with ethanol with 4 times the volume of the medicinal material for 2 hours , for the third time, extract with ethanol that is 4 times the volume of the medicinal material for 1 hour, combine the extracts, filter, recover the ethanol, and use the obtained solution for later use;

[0049] 2) Process safflower and Rhododendron by steam distillation, take 80g of dried safflower and 200g of Rhododendron, pulverize them with a common pulverizer and pass through a 50-mesh sieve, then mix them evenly, and extract 5 by boiling with 6 times the volume of water hours, using n-hexane to extract the water extract to obtain an ...

Embodiment 2

[0064] Embodiment 2, the capsules prepared respectively in Example 1 and Comparative Example 1 are used clinically, and its curative effect on the original disease is compared

[0065] In order to compare the curative effect of Jingzhu Jingtian Quban Capsule prepared by the present invention and Jingzhu Today Quban Capsule prepared by the original method, Beijing Jingzhu Traditional Chinese Medicine Hospital included 120 patients with chloasma, and were randomly divided into A group and B group, each 60 cases. Wherein Group A was treated with Jingzhu Jingtian Quban Capsule prepared by the present invention (Example 1), and Group B was treated with Jingzhu Jingtian Quban Capsule prepared by the original method (Comparative Example 1). Both groups were given 2 times a day, 4 capsules each time, 3 months as a course of treatment.

[0066] The curative effect judging standard is: the integral is calculated by the sum of the skin lesion area and the skin color score. Lesion area ...

Embodiment 3

[0074] Embodiment 3, using the capsules prepared respectively in Example 1 and Comparative Example 1 for clinical use, and comparing their curative effects against new indications

[0075] Beijing Jingzhu Hospital of Traditional Chinese Medicine used the Jingzhu Jingtian Quban Capsule prepared by the present invention in the process of treating chloasma, and found that the medicine also had a curative effect on female patients with primary dysmenorrhea of ​​Qi stagnation and blood stasis type. Preliminary observations were made. Sixty cases of primary dysmenorrhea patients of Qi stagnation and blood stasis type were randomly divided into treatment group and control group, 30 cases in each group. The treatment group was treated with Jingzhu Jingtian Quban Capsules prepared by the present invention, and the control group was treated with Jingzhu Jingtian Quban Capsules prepared by the original method. They were treated for 3 months, and the curative effect and visual analogue sc...

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Abstract

The invention discloses a preparation method of a skincare chloasma dispeling capsule. The preparation method comprises the following steps: performing reflux extraction on a mixture of herba Rhodiolae, radix polygoni multiflori praeparata and radix angelicae sinensis for at least three times by adopting an ethanol aqueous solution, merging extraction solutions, filtering, and recovering the ethanol to obtain a solution; treating a mixture of flos carthami and flos rhododendron simsii by adopting a vapor distillation method, and obtaining volatile oil and drug residue; mixing the drug residue,fructus lycii and radix astragali, decocting in water for at least three times, mixing the decoctions, and filtering to obtain filtrate; (4) mixing the filtrate and the solution, and concentrating toobtain thick paste; crushing pearls into pearl powder; uniformly mixing the thick paste and the pearl powder, drying, and crushing to obtain fine powder; and uniformly mixing the fine powder and thevolatile oil, and loading the mixture in a capsule, thus obtaining the skincare chloasma dispeling capsule. The flos carthami and the flos rhododendron simsii are used for substituting radix rehmanniae and radix rehmanniae preparata in the original formula, and the flos carthami and flos rhododendron simsii volatile oil is used in the drug, so that the drug acting time can be further shortened, and the treatment efficiency can be improved.

Description

technical field [0001] The invention relates to a preparation method of a beauty-beautifying and freckle-removing capsule, which belongs to the technical field of cosmetics. Background technique [0002] Chloasma is acquired irregular brown pigmentation on the face. It is generally believed that it is related to endocrine disorders, sun exposure, emotions and other factors. In recent years, the incidence rate has been on the rise, and the age of onset tends to be younger. [0003] There is currently no effective treatment for this disease. Hydroquinone cream and retinoic acid drugs have certain effects, but there are also shortcomings: when the concentration of hydroquinone cream is high, the curative effect is improved, but the irritation is aggravated, and long-term use can lead to exogenous chloasma; It takes about half a year for the medicine to gradually take effect. Jingzhu Jingtian Quban Capsules are selected from plateau medicinal materials, composed of Rhodiola ro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/9789A61K8/92A61K8/11A61Q19/02A61K36/815A61K9/48A61P17/00A61P15/00A61K35/618
CPCA61P15/00A61P17/00A61Q19/02A61K8/11A61K8/922A61K8/9789A61K8/987A61K9/48A61K35/618A61K36/232A61K36/286A61K36/41A61K36/45A61K36/481A61K36/704A61K36/815A61K2236/39A61K2236/51A61K2236/331A61K2236/333A61K2300/00
Inventor 李方瑞
Owner 青海晶珠藏药高新技术产业股份有限公司
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