Method for production of 2, 6-dimethyl-4-tert-butylacetophenone with tubular reactor

Abstract

The invention provides a method for production of 2, 6-dimethyl-4-tert-butylacetophenone with a tubular reactor. The method includes the steps of: S1, preparing an aluminum chloride ethanol solution,adding alumina and isopropanol to obtain a mixture A, conducting ultrasonic dispersion on cobaltosic oxide, nickel powder, 2-chloro-5-nitropyridine, 4-nitropyrazole, tetrathiafulvalene and anhydrous ethanol, adding a mixture A and then performing treatment to obtain a catalyst; S2, mixing dichloroethane with the catalyst to obtain a mixture B; S3, subjecting the mixture B, acetyl chloride and 1, 3-dimethyl-5-tert-butylbenzene to acylation reaction in a tubular reactor, and discharging the reaction liquid from an upper discharge hole; and S4, centrifuging the reaction liquid, and respectively treating the supernatant and filter cake, thus obtaining the recovered catalyst and 2, 6-dimethyl-4-tert-butylacetophenone. The method provided by the invention utilizes the tubular reactor for continuous production, and has the advantages of simple operation, short time, few three industrial wastes, few by-product and high yield.

Description

technical field [0001] The invention relates to the technical field of organic synthesis, in particular to a method for producing 2,6-dimethyl-4-tert-butylacetophenone by using a tubular reactor. Background technique [0002] Ketone musk is 3,5-dinitro-2,6-dimethyl-4-tert-butylacetophenone, a kind of nitro musk, with a soft musky aroma, soluble in almost all spices, synthetic route Short, is widely used in perfume essence, soap essence, cosmetic essence and other fields. 2,6-dimethyl-4-tert-butyl acetophenone is the main raw material for the synthesis of ketone musk, and with the increase of demand for ketone musk, 2,6-dimethyl-4-tert-butyl acetophenone The demand is also increasing, and the current method of producing 2,6-dimethyl-4-tert-butylacetophenone is mainly based on 1,3-dimethyl-5-tert-butylbenzene and acetyl chloride as raw materials , in the presence of aluminum trichloride, through batch production, but this method requires complex operation of pouring the kett...

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the complex operation, long time-consuming, many by-products, low product yield, large amount of industrial three wastes, unfriendly to the environment, and the hydrochloric acid produced in the prior art will cause corrosion to the equipment and affect the equipment. The problem of service life, and a kind of method that adopts tubular reactor to produce 2,6-dimethyl-4-tert-butyl acetophenone proposed