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Preparation method of traditional Chinese medicine composition

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve problems such as low patient compliance and poor taste of medicine, and achieve the effects of good taste, enhanced compliance, and simple preparation method

Inactive Publication Date: 2019-02-01
山东罗欣乐康制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The preparation method of the original preparation is that the medicinal material is extracted by dipping and percolating with ethanol solution, concentrated under reduced pressure, and formulated into an oral liquid. The taste of the medicine is not good, and the patient's compliance is low.

Method used

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  • Preparation method of traditional Chinese medicine composition
  • Preparation method of traditional Chinese medicine composition
  • Preparation method of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Prescription: Rehmannia glutinosa 10g, Ophiopogon japonicus 10g, Scrophulariaceae 15g, Forsythia suspensa 33g, Scutellaria baicalensis Georgi 32g.

[0031] Process:

[0032] (1) Take the prescription amount of Rehmannia glutinosa, Ophiopogon japonicus, Scrophulariaceae, Forsythia suspensa and Scutellaria baicalensis and pulverize into coarse powder; take 100g of the crude Chinese medicine mixture, add 0.8L ethyl acetate for the first time, reflux for 60min at 70°C for the second time; Add 0.5L ethyl acetate and reflux for 30min at the same temperature.

[0033] (2) The extract obtained above is filtered, and the filtrate is centrifuged and purified at a rotation speed of 6000 rpm / min to obtain a concentrated solution.

[0034] (3) Add 0.5 part of sucrose and 0.5 part of dextrin as auxiliary materials to the concentrated solution and mix well. The above mixture was vacuum dried at 30°C for 2h; then dry granulation was carried out, and the preparation was prepared by conventiona...

Embodiment 2

[0036] Prescription: Rehmannia glutinosa 10g, Ophiopogon japonicus 10g, Scrophulariaceae 15g, Forsythia suspensa 33g, Scutellaria baicalensis Georgi 32g.

[0037] Process:

[0038] (1) Take the prescription amount of Rehmannia glutinosa, Ophiopogon, Scrophulariaceae, Forsythia suspensa, Scutellaria baicalensis and pulverize into coarse powder; take 100g of the crude Chinese medicine mixture, add 2L ethyl acetate for the first time, reflux at 90℃ for 120min; add for the second time 1.5L ethyl acetate, reflux at the same temperature for 90min; add 1L ethyl acetate for the third time, reflux at the same temperature for 60min.

[0039] (2) The extract obtained above is filtered, and the filtrate is centrifuged at a high speed for purification and separation at a speed of 10000 rpm / min to obtain a concentrated solution.

[0040] (3) Add 2 parts of sucrose and 2 parts of dextrin to the concentrated liquid as auxiliary materials, and mix well. The above mixture was vacuum dried at a tempera...

Embodiment 3

[0042] Prescription: Rehmannia glutinosa 10g, Ophiopogon japonicus 10g, Scrophulariaceae 15g, Forsythia suspensa 33g, Scutellaria baicalensis Georgi 32g.

[0043] Process:

[0044] (1) Take the prescription amount of Rehmannia glutinosa, Ophiopogon japonicus, Scrophulariaceae, Forsythia suspensa, Scutellaria baicalensis Georgi and pulverize into coarse powder; take 100g of the crude Chinese medicine mixture, add 1.5L ethyl acetate for the first time, and extract at 75°C for 90 min; Add 1.2L ethyl acetate and reflux at the same temperature for 60min; add 0.8L ethyl acetate for the third time and reflux at the same temperature for 30min.

[0045] (2) The extract obtained above is filtered, and the filtrate is centrifuged at a high speed for purification and separation at a speed of 7000 rpm / min to obtain a concentrated solution.

[0046] (3) Add 1 part of sucrose and 1 part of dextrin as auxiliary materials to the concentrated solution, and mix well. The above mixture was vacuum dried ...

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Abstract

The invention belongs to the technical field of medicine, and discloses a preparation method of a traditional Chinese medicine composition. According to the preparation method, ethyl acetate is takenas a solvent, heating reflux extraction is adopted so as to obtain a traditional Chinese medicine combination capable of clearing throats; high speed centrifugal process is adopted separation, purifying, drying, and dry method pelletizing are carried out, so that a solid preparation is prepared through a routine method. The preparation method is capable of shortening production period, increasingeffective component extraction rate, reducing dissolving out of ineffective components, achieving more accurate prescription curative effect, and improving medicine application safety.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method of a traditional Chinese medicine composition, in particular to a preparation method of a solid preparation of a Chinese medicine composition for clearing the throat and throat. Background technique [0002] Qinghouyan Mixture is a traditional Chinese medicine compound preparation prepared from the five medicinal materials of Rehmannia, Ophiopogon, Scrophulariaceae, Forsythia and Scutellaria. It is currently included in the 2015 Chinese Pharmacopoeia. Its functions and indications are: nourishing yin and clearing lungs, relieving throat and detoxification. Used for pharyngeal swelling and pain caused by yin deficiency, dry heat and fire poison, dry throat and less fluid, pharyngeal white rot with moss, and laryngeal nucleus enlargement; limited pharyngeal diphtheria, mildly toxic diphtheria, acute tonsils Inflammation and angina see the above syndromes. [0003] Th...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61P11/04
CPCA61K36/539A61K36/634A61K36/804A61K36/808A61K36/8968A61K2236/33A61K2236/39A61K2236/51A61P11/04A61K2300/00
Inventor 周晨吴振民姚青
Owner 山东罗欣乐康制药有限公司
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