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Composite hydrogel loaded with vascular disrupting agent and near-infrared optothermal response nanometer particles as well as preparation and applications of composite hydrogel

A technology of composite hydrogel and vascular blocking agent, which is applied in the fields of oncology and pharmacy, can solve the problems of easy drug resistance and large side effects of chemotherapy, etc., and achieve enhanced tumor permeability, long-acting drug delivery, and enhanced flow sexual effect

Inactive Publication Date: 2019-01-29
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As we all know, chemotherapy has many side effects and is prone to drug resistance
There is no literature report on co-loading vasoblocking agents with near-infrared photothermal responsive nanoparticles on hydrogel carriers to achieve combined therapy of photothermal and vasoblocking agents

Method used

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  • Composite hydrogel loaded with vascular disrupting agent and near-infrared optothermal response nanometer particles as well as preparation and applications of composite hydrogel
  • Composite hydrogel loaded with vascular disrupting agent and near-infrared optothermal response nanometer particles as well as preparation and applications of composite hydrogel
  • Composite hydrogel loaded with vascular disrupting agent and near-infrared optothermal response nanometer particles as well as preparation and applications of composite hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Preparation of Prussian Blue Nanoparticles by Reductive Dispersion Method of Polyvinylpyrrolidone (PVP)

[0051] Take by weighing 15g polyvinylpyrrolidone (PVP) and 664mg red blood salt (K 3 [Fe(CN) 6 ]), add 200mL 0.01M HCl, stir at room temperature for 30min, transfer to 80℃ constant temperature oil bath to react for 20h, cool to room temperature after the reaction, centrifuge at high speed for 20min, remove the supernatant, wash with secondary water until neutral, freeze-dry spare.

Embodiment 2

[0052] Embodiment 2. Sodium citrate modified precipitation method prepares Prussian blue nanoparticles

[0053] Weigh 0.10g sodium citrate and add 20mL FeCl 3 (1mM) solution, weigh 0.10g sodium citrate and add 20mLK 4 [Fe(CN) 6 ] (1mM) aqueous solution, under constant temperature stirring at 60°C, sodium citrate / K 4 [Fe(CN) 6 ] The mixed solution was added dropwise into the sodium citrate / FeCl3 mixed solution, and after it was cooled to room temperature, the stirring was continued for 30 min to obtain Prussian blue nanoparticles.

Embodiment 3

[0054] Example 3. Preparation of Mesoporous Prussian Blue Nanoparticles

[0055] Weigh 0.08g of Prussian blue (Prussian blue, PB) nanoparticles and 125mg of PVP, add them to 80mL of 1.0M HCl, stir for 30min, transfer to a 100mL reaction kettle, place in a 140°C oven for 4h, centrifuge at high speed for 20min, collect The precipitate was washed with secondary water until neutral, and freeze-dried for later use.

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Abstract

The invention relates to an injectable composite hydrogel loaded with a vascular disrupting agent and near-infrared optothermal response nanometer particles and applications in resisting tumor. The composite hydrogel comprises a hydrogel substrate material, as well as the vascular disrupting agent and the near-infrared optothermal response nanometer particles loaded in the hydrogel substrate material. The prepared nanometer composite hydrogel has the sol-gel converting behavior realizing syringeability and thermal hysteresis. Under the illumination of near-infrared light, the hybridized hydrogel has the excellent optothermal property, and meanwhile, the curative effects of the vascular disrupting agent are improved by enhancing the permeability of the tumor vessels. The hybridized hydrogeladopting the combined treatment of the vascular disrupting agent and the optothermal function has good safety and curative effects in resisting tumor.

Description

technical field [0001] The invention relates to an injectable hydrogel co-loaded with a blood vessel blocking agent and near-infrared photothermal responsive nanoparticles and its anti-tumor application, belonging to the fields of pharmacy and oncology. Background technique [0002] Tumor tissue is composed of parenchyma and stroma. Tumor parenchyma is tumor cells, which are the main components of tumors and have tissue source specificity. The stroma of the tumor plays the role of supporting and nourishing the tumor parenchyma, which is not specific, including connective tissue, blood vessels, lymphatic vessels, etc. [0003] Vascular disrupting agents (VDAs) are a class of antitumor drugs that selectively damage tumor-related blood vessels. This type of drug selectively destroys tumor-related blood vessels, blocks the supply of nutrients and oxygen to tumor tissue, and causes secondary tumor cell death, thereby achieving the purpose of targeted treatment of tumors. Howeve...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/36A61K31/09A61K41/00A61P35/00
CPCA61K9/0024A61K9/06A61K31/09A61K41/0052A61K47/36A61P35/00A61K2300/00
Inventor 李娟梁育晴郝义俊孙晓毅刘又年
Owner CENT SOUTH UNIV
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