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Blood purification membrane with anticoagulant property and preparation method thereof

A technology for blood purification and performance, applied in the field of surface modification of blood purification membranes, can solve the problems of complex modification methods of blood purification membranes, poor anticoagulation effect of blood purification membranes, and limited application range, etc. The effect of capacitance, modification process is simple and easy, and the controllability is strong

Active Publication Date: 2019-01-18
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem solved by the present invention is that the anticoagulation effect of the blood purification membrane is not good, and the application range is not wide; the modification method of the blood purification membrane is relatively complicated, and the reaction conditions are harsh

Method used

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  • Blood purification membrane with anticoagulant property and preparation method thereof
  • Blood purification membrane with anticoagulant property and preparation method thereof
  • Blood purification membrane with anticoagulant property and preparation method thereof

Examples

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example 1

[0037] A blood purification membrane with anticoagulant properties and a preparation method thereof, adopting the following steps:

[0038] 1) Weigh 1.784g of polyethersulfone (PES) raw material, dissolve it in 10ml of dimethylacetamide (DMAC), at room temperature, magnetically stir to obtain a light yellow casting solution, let it stand overnight to remove foam, and dissolve it in pure water at 4°C Prepare the membrane according to the liquid-liquid phase conversion method to obtain the PES substrate, soak in double distilled water for 3 days, and set aside;

[0039] 2) Weigh 0.2436g of tris (tris) and dissolve it in double-distilled water, add concentrated hydrochloric acid, adjust the pH to 8.5, and dilute the solution to 200ml to prepare a pH=8.5 10mmol / L tris solution. PES matrix with smooth surface and uniform thickness was placed in the prepared tris solution, and then 0.4g dopamine was weighed and dissolved in 200ml tris solution, protected from light, and shaken on a ...

example 2

[0043] A blood purification membrane with anticoagulant properties and a preparation method thereof, adopting the following steps:

[0044] 1) Weigh 1.784g of PES raw material, dissolve it in 10ml of DMAC, and stir it with magnetic force at room temperature to obtain a light yellow casting liquid, let it stand overnight to defoam, and make a film in pure water at 4°C according to the liquid-liquid phase conversion method to obtain a PES matrix , after soaking in double distilled water for 3 days, set aside;

[0045] 2) Weigh 0.2436g of tris (tris) and dissolve it in double-distilled water, add concentrated hydrochloric acid, adjust the pH to 8.5, and dilute the solution to 200ml to prepare a pH=8.5 10mmol / L tris solution. Several PES substrates with smooth surface and uniform thickness were placed in the prepared tris solution, then weighed 0.4g of dopamine and dissolved in the tris solution, protected from light, and shaken on a shaker for 8 hours (30°C, 173r / min) to obtain a...

example 3

[0049] A blood purification membrane with anticoagulant properties and a preparation method thereof, adopting the following steps:

[0050] 1) Weigh 1.784g of PES raw material, dissolve it in 10ml of DMAC, and stir it with magnetic force at room temperature to obtain a light yellow casting liquid, let it stand overnight to defoam, and make a film in pure water at 4°C according to the liquid-liquid phase conversion method to obtain a PES matrix , after soaking in double distilled water for 3 days, set aside;

[0051] 2) Weigh 0.2436g of tris (tris) and dissolve it in double-distilled water, add concentrated hydrochloric acid, adjust the pH to 8.5, and dilute the solution to 200ml to prepare a pH=8.5 10mmol / L tris solution. Several PES substrates with smooth surface and uniform thickness were placed in the prepared tris solution, then weighed 0.4g of dopamine and dissolved in the tris solution, protected from light, and shaken on a shaker for 8 hours (30°C, 173r / min) to obtain a...

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Abstract

The invention discloses a blood purification membrane with an anticoagulant property and a preparation method thereof. The blood purification membrane comprises a matrix, a polydopamine layer attachedto the surface of the substrate, argatroban grafted on the polydopamine layer and glutathione. The whole surface modification process is simple in experimental conditions, has strong controllability,and is economical and environmentally-friendly; the high-efficiency anti-coagulation on the local part of a material is realized; the blood coagulation system of a body is not affected; the blood compatibility is significantly improved; and the grafted anticoagulant drug argatroban has no antigenicity and does not cause heparin-induced thrombocytopenia.

Description

technical field [0001] The invention relates to a blood purification membrane with anticoagulant performance and a preparation method thereof, belonging to the surface modification technology of the blood purification membrane. Background technique [0002] When biological materials such as blood purification filter membranes are in direct contact with blood, due to bioincompatibility and other reasons, they will adsorb plasma proteins and blood cells in the blood, thereby activating platelets, coagulation system, and complement system, and coagulation and thrombus formation on the surface of biological materials . Therefore, when blood purification is performed clinically, anticoagulant treatment is required for patients, but the use of anticoagulants is contraindicated for patients with high-risk bleeding tendency. Facing the dilemma of not only preventing coagulation of extracorporeal blood, but also ensuring that the blood flow / coagulation status in the human body is no...

Claims

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Application Information

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IPC IPC(8): B01D71/68B01D71/58B01D69/12A61M1/16
CPCA61M1/16B01D69/12B01D71/58B01D71/68
Inventor 宁建平戴艳玲代思源府晓
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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