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Nitrogen and sulfur double-doped yellow fluorescence carbon dot and application thereof in anticancer medicine

A yellow fluorescent and sulfur bis-based technology, applied in the field of yellow fluorescent carbon dots and its preparation, can solve the problems of targeted recognition and diagnosis of few cancer cells and complex process of functionalized fluorescent CDs

Inactive Publication Date: 2019-01-15
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are very few reports on the targeted recognition and diagnosis of cancer cells by functionalized fluorescent CDs, and the process of preparing functionalized fluorescent CDs is relatively complicated.

Method used

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  • Nitrogen and sulfur double-doped yellow fluorescence carbon dot and application thereof in anticancer medicine
  • Nitrogen and sulfur double-doped yellow fluorescence carbon dot and application thereof in anticancer medicine
  • Nitrogen and sulfur double-doped yellow fluorescence carbon dot and application thereof in anticancer medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Preparation of nitrogen and sulfur double-doped yellow fluorescent carbon dots:

[0033] (1) Add 0.48g of methyl-β-cyclodextrin and 0.16g of methylene blue to 20mL of deionized water respectively to prepare a mixed solution;

[0034] (2) Transfer the mixed solution obtained in step (1) to a hydrothermal reaction kettle, and conduct a hydrothermal reaction at 180° C. for 5 hours;

[0035] (3) Centrifuge the product obtained in step (2) at a speed of 8000r / min for 8min, and then dialyze for 24h with a dialysis bag with a molecular weight cut-off of 500-1000Da to finally obtain a nitrogen-sulfur double-doped yellow fluorescent carbon dot solution.

Embodiment 2

[0037] Preparation of nitrogen and sulfur double-doped yellow fluorescent carbon dots:

[0038] (1) Add 0.48g of methyl-β-cyclodextrin and 0.16g of methylene blue to 20mL of deionized water respectively to prepare a mixed solution;

[0039] (2) Transfer the mixed solution obtained in step (1) to a hydrothermal reaction kettle, and conduct a hydrothermal reaction at 200° C. for 5 hours;

[0040] (3) Centrifuge the product obtained in step (2) at a speed of 8000r / min for 8min, and then dialyze for 24h with a dialysis bag with a molecular weight cut-off of 500-1000Da to finally obtain a nitrogen-sulfur double-doped yellow fluorescent carbon dot solution.

Embodiment 3

[0042] Preparation of nitrogen and sulfur double-doped yellow fluorescent carbon dots:

[0043] (1) Add 0.48g of methyl-β-cyclodextrin and 0.16g of methylene blue to 20mL of deionized water respectively to prepare a mixed solution;

[0044] (2) Transfer the mixed solution obtained in step (1) to a hydrothermal reaction kettle, and conduct a hydrothermal reaction at 220° C. for 5 hours;

[0045] (3) Centrifuge the product obtained in step (2) at a speed of 8000r / min for 8min, and then dialyze for 24h with a dialysis bag with a molecular weight cut-off of 500-1000Da to finally obtain a nitrogen-sulfur double-doped yellow fluorescent carbon dot solution.

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Abstract

The invention provides a nitrogen and sulfur double-doped yellow fluorescence carbon dot and application thereof in anticancer medicine. Methyl-beta-cyclodextrin and methylene blue are used as raw materials; water is used as a solvent; the nitrogen and sulfur double-doped yellow fluorescence carbon dot is prepared by a hydro-thermal method. The prepared nitrogen and sulfur double-doped yellow fluorescence carbon dot can physically adsorb anti-tumor medicine mitoxantrone, so that a fluorescence nanometer medicine system combining tracking with treatment is obtained. Through the nanometer medicine system, the fluorescence is given to the mitoxantrone without the influence on the anti-cancer effect of the mitoxantrone. The prepared yellow fluorescence carbon dot has the advantages of good water solubility, stable fluorescence performance, good biocompatibility and low toxicity, and has wide application prospects in the fields of biological imaging, medicine delivery and the like.

Description

technical field [0001] The invention relates to nanometer materials and anticancer drugs, in particular to a yellow fluorescent carbon dot loaded with anticancer drugs and its preparation method and application. Background technique [0002] Carbon nanodots, also known as carbon dots, are a new class of carbon nanomaterials with a size smaller than 10nm, which were first discovered in 2004 when single-layer carbon nanotubes were purified by electrophoresis. Due to their low cost, small particle size, good water solubility, high chemical inertness, easy functionalization, resistance to photobleaching, no light flickering, low toxicity and good biocompatibility, carbon dots have gradually become a promising alternative for other fluorescent nanomaterials. Excellent alternative to materials. These unique properties of carbon dots make them useful in many practical applications, such as bioimaging, drug delivery, chemical sensors and biosensors, gene delivery, dye sensitizers, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65B82Y20/00B82Y40/00A61K49/00A61K31/136A61P35/00
CPCA61K31/136A61K49/0021A61P35/00B82Y20/00B82Y40/00C09K11/65
Inventor 李英奇温香平
Owner SHANXI UNIV
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