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Methods for preparing and detecting a compound dyers woad leaf suppository

A detection method, the technology of Daqingye, is applied in the field of medicine to meet the needs of industrial production, with high stability and strong specificity

Inactive Publication Date: 2019-01-15
RONGCHANG PHARM ZIBO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As of the deadline, there is no literature report on the comprehensive quality inspection of this product

Method used

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  • Methods for preparing and detecting a compound dyers woad leaf suppository
  • Methods for preparing and detecting a compound dyers woad leaf suppository
  • Methods for preparing and detecting a compound dyers woad leaf suppository

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Weigh an appropriate amount of medicinal materials in proportion, extract the volatile oil of notopterygium with steam distillation, decoct the medicinal residues and other four flavors such as Folium Isatidis and other four flavors with water for three times, one hour each time, combine the decoctions, filter, concentrate under reduced pressure to relative density, add Ethanol until the alcohol content is 60%, let it stand for 12 hours, filter, recover the ethanol from the filtrate under reduced pressure to an appropriate amount, then add ethanol until the alcohol content is 85%, refrigerate for more than 12 hours, filter, recover ethanol, and concentrate under reduced pressure to relative A thick paste with a density of 1.26. Take 500g of the extract thick paste, add 40ml of Span 80, grind, add 1000g of mixed fatty acid glycerides melted at 36°C, 80ml of volatile oil, grind for 10 minutes, pour it, and make 1000 suppositories.

[0048] Identification of contents and c...

Embodiment 2

[0110] Weigh an appropriate amount of medicinal materials in proportion, extract the volatile oil of notopterygium with steam distillation, decoct the medicinal residues and other four flavors such as Folium Isatidis and other four flavors with water for three times, one hour each time, combine the decoctions, filter, concentrate under reduced pressure to relative density, add Ethanol until the alcohol content is 60%, let it stand for 12 hours, filter, recover the ethanol from the filtrate under reduced pressure to an appropriate amount, then add ethanol until the alcohol content is 85%, refrigerate for more than 12 hours, filter, recover ethanol, and concentrate under reduced pressure to relative A thick paste with a density of 1.26. Take 500g of the extract thick paste, add 50ml of Span 80, grind, add 1000g of mixed fatty acid glycerides melted at 40°C, 80ml of volatile oil, grind for 15 minutes, pour, and make 1000 suppositories.

[0111] The identification of content and t...

Embodiment 3

[0113] Weigh an appropriate amount of medicinal materials in proportion, extract the volatile oil of notopterygium with steam distillation, decoct the medicinal residues and other four flavors such as Folium Isatidis and other four flavors with water for three times, one hour each time, combine the decoctions, filter, concentrate under reduced pressure to relative density, add Ethanol until the alcohol content is 60%, let it stand for 12 hours, filter, recover the ethanol from the filtrate under reduced pressure to an appropriate amount, then add ethanol until the alcohol content is 85%, refrigerate for more than 12 hours, filter, recover ethanol, and concentrate under reduced pressure to relative A thick paste with a density of 1.26. Take 500g of the extract thick paste, add 60ml of Span 80, grind, add 1000g of mixed fatty acid glycerides melted at 45°C, 80ml of volatile oil, grind for 20 minutes, pour, and make 1000 suppositories.

[0114] The identification of content and t...

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Abstract

The invention belongs to the technical field of medicine, in particular to methods for preparing and detecting a compound dyers woad leaf suppository. The suppository is prepared from the following raw materials in parts by weight: 460-500 g of a Chinese medicinal extract prepared from dyers woad leaves, honeysuckle flower, notopterygium root, rhubarb and bistort rhizome in a ratio of 4:2:1:1:1, and containing chlorogenic acid not less than 8 mg / g and emodin chrysophanol not less than 0.9 mg / g, 900-1000 g of fatty acid glyceride matrix, 40-60 mL of span 80 and 80-120 ml of volatile oil. TLC isused to identify indirubin, chlorogenic acid, rhubarb and Notopterygium root, and HPLC is used to determine emodin and chrysophanol in Compound Isatis Suppository. The preparation method is simple and feasible, and meets the needs of industrial production; The detection method is scientific, specific, simple, sensitive and stable, which improves the effective control of drug quality and guarantees the quality.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a preparation and detection method of compound Folium Folium Suppository. Background technique [0002] Compound Daqingye Suppository is a traditional Chinese medicine suppository developed and produced by our company in the 1980s. It has the functions of clearing away plague and detoxifying, relieving exterior and dispelling wind. [0003] From the manual production in the 1980s to the modern mechanized production, the process has undergone major changes, and the production technology is difficult. Problems such as poor properties, uneven content, storage deformation and melting often occur. However, the original quality detection method is poor in controllability and specificity, and the influence of human operation is relatively large. Only the titration method is used to detect the content of non-main substance glycosides. There is no strict quality control inde...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/855A61K36/708A61K9/02A61P11/00A61P31/16A61P31/14G01N30/02G01N30/06G01N30/90
CPCA61K9/02A61K36/195A61K36/237A61K36/315A61K36/355A61K36/704A61K36/708A61K36/855A61K47/44A61K2236/331A61K2236/39A61K2236/51A61K2236/53G01N30/02G01N30/06G01N30/90G01N2030/042A61K2300/00
Inventor 王荔强翟勇孔静王爱云时延利宁乐李敏王烽竹郭桂秋
Owner RONGCHANG PHARM ZIBO CO LTD
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