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Drug release-controlled calcium phosphate bone cement composite microsphere and preparation method and application thereof

A technology of calcium phosphate bone cement and composite microspheres, which can be used in drug delivery, pharmaceutical formulations, and medical science. It can solve the problems of uncontrollable drug release rate, slow degradation of scaffolds, and unfavorable rapid bone healing. It achieves good biological activity and Effects of degradability, promotion of cell proliferation, good disintegration resistance

Active Publication Date: 2019-01-01
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, drug-loaded polymer microspheres such as PLGA, gelatin microspheres, etc., are combined with calcium phosphate bone cement to achieve the purpose of bone defect repair and reconstruction and local drug treatment, but the composite scaffold of polymer microspheres and calcium phosphate bone cement degrades Slow, not conducive to rapid bone healing, drug release rate can not be controlled

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  • Drug release-controlled calcium phosphate bone cement composite microsphere and preparation method and application thereof
  • Drug release-controlled calcium phosphate bone cement composite microsphere and preparation method and application thereof
  • Drug release-controlled calcium phosphate bone cement composite microsphere and preparation method and application thereof

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Embodiment 1

[0038] As an embodiment of the preparation method of the drug controlled release calcium phosphate bone cement composite microspheres of the present invention, the preparation method of the drug controlled release calcium phosphate bone cement composite microspheres described in this embodiment comprises the following steps:

[0039] (1) sodium alendronate is dissolved in water to obtain a drug solution, and the mass fraction of sodium alendronate in the drug solution is 1%; The mass ratio is 100:0.5, after ultrasonic treatment for 30 minutes, centrifugation and drying to obtain drug-loaded mesoporous calcium silicate;

[0040] The preparation method of the mesoporous calcium silicate is: adding calcium hydroxide to deionized water, adding ethanol, and stirring evenly to obtain a calcium hydroxide solution, the mass fraction of ethanol in the calcium hydroxide solution being 5%; Add ethyl orthosilicate dropwise into the calcium hydroxide solution, stir for 3-6 hours, centrifug...

Embodiment 2

[0047] As an embodiment of the preparation method of the drug controlled release calcium phosphate bone cement composite microspheres of the present invention, the preparation method of the drug controlled release calcium phosphate bone cement composite microspheres described in this embodiment comprises the following steps:

[0048] (1) sodium alendronate is dissolved in water to obtain a drug solution, and the mass fraction of sodium alendronate in the drug solution is 1%; The mass ratio is 100:0.6, after ultrasonic treatment for 30 minutes, centrifugation and drying to obtain drug-loaded mesoporous calcium silicate;

[0049] The preparation method of the mesoporous calcium silicate is: adding calcium hydroxide to deionized water, and adding ethanol, and stirring evenly to obtain a calcium hydroxide solution, and the mass fraction of ethanol in the calcium hydroxide solution is 4%; Add ethyl orthosilicate dropwise into the calcium hydroxide solution, stir for 3-6 hours, cent...

Embodiment 3

[0056] As an embodiment of the preparation method of the drug controlled release calcium phosphate bone cement composite microspheres of the present invention, the preparation method of the drug controlled release calcium phosphate bone cement composite microspheres described in this embodiment comprises the following steps:

[0057] (1) sodium alendronate is dissolved in water to obtain a drug solution, and the mass fraction of sodium alendronate in the drug solution is 3%; The mass ratio is 100:0.6, after ultrasonic treatment for 50 minutes, centrifugation and drying to obtain drug-loaded mesoporous calcium silicate;

[0058] The preparation method of the mesoporous calcium silicate is: adding calcium hydroxide to deionized water, adding ethanol, and stirring evenly to obtain a calcium hydroxide solution, the mass fraction of ethanol in the calcium hydroxide solution being 5%; Add ethyl orthosilicate dropwise into the calcium hydroxide solution, stir for 3-6 hours, centrifug...

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Abstract

The invention discloses a drug release-controlled calcium phosphate bone cement composite microsphere and a preparation method and application thereof. The preparation method comprises the following steps of compounding silk fibroin and carboxymethyl chitosan; using a calcium phosphate bone cement solid-phase powder as the raw material, and combining with a liquid droplet condensing method, so asto obtain the calcium phosphate bone cement composite microsphere. The preparation method has the advantages that the preparation method is simple, and the high-temperature sintering is not required;the calcium phosphate bone cement composite microsphere has higher mechanical strength, and good anti-collapsing property, degradability and cell compatibility; the mesoporous calcium silicate contains a large amount of mesopores and can adsorb the drug, and the medicine release-controlled effect is realized after the mesoporous calcium silicate as a drug carrier is added into the calcium phosphate bone cement microsphere, so that the calcium phosphate bone cement microsphere has the effects of bone reconstruction and drug treatment.

Description

technical field [0001] The invention relates to the technical field of bone repair materials, in particular to a drug-controlled calcium phosphate bone cement composite microsphere, its preparation method and application. Background technique [0002] Calcium Phosphate Cement (CPC) was successfully developed by Brown and Chow in the 1990s. It is a self-curing non-ceramic hydroxyapatite artificial bone material. It is composed of solid phase powder and solidification liquid mixed according to a certain ratio to form an easy-to-shape slurry, which solidifies itself in a short time, and the final hydration product is apatite, which is similar to the inorganic composition and crystal structure of human bone tissue. . CPC has good osteoconductivity and biocompatibility, and can be shaped arbitrarily during surgery to fill bone defects of various shapes. It has been widely used in the fields of bone defect repair, maxillofacial surgery repair and drug carrier. [0003] Compared ...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/58A61L27/54
CPCA61L27/46A61L27/54A61L27/58A61L2300/622A61L2430/02C08L5/08C08L89/00
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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