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Preparation method and application of traditional Chinese medicine extract for treating nasosinusitis and bronchitis

A technology of extract and traditional Chinese medicine, applied in the field of traditional Chinese medicine, can solve the problems of taking, inconvenient to carry, taking a large amount, unsuitable for processing, etc.

Inactive Publication Date: 2018-12-21
海王百草堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Traditionally, the preparation process and administration method of this prescription is mainly to take powder: and the traditional powder process parameters are not, it can be seen that the traditional process is rough, and it is inconvenient to take and carry, the dosage is large, and it is not suitable for processing into other dosage forms

Method used

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  • Preparation method and application of traditional Chinese medicine extract for treating nasosinusitis and bronchitis
  • Preparation method and application of traditional Chinese medicine extract for treating nasosinusitis and bronchitis
  • Preparation method and application of traditional Chinese medicine extract for treating nasosinusitis and bronchitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1 Water extraction method prepares " magnolia powder " side Chinese medicine extract

[0043] Method 1: Take magnolia, asarum, ligusticum, cohosh, chuanxiong, akebia, fangfeng, notopterygium, licorice and angelica as raw materials, and use water as a solvent to extract the raw materials. The weight ratio of each raw material is magnolia: asarum: Ben: Cimicifuga: Chuanxiong: Akebia: Fangfeng: Notopterygium: Licorice: Angelica dahurica = 1:1:1:1:1:1:1:1:1:1:1; cleanly select the above medicinal materials and weigh them in proportion Magnolia 50 kg, Asarum 50 kg, Ligusticum 50 kg, Cimicifuga 50 kg, Rhizoma Chuanxiong 50 kg, Akebia 50 kg, Fangfeng 50 kg, Notopterygium 50 kg, Licorice 50 catties, Angelica dahurica 50 kg, soak in 5.0 tons of water for 20 minutes, Heating and extracting 3 times (2h for the first time, 1h for the second time, 30min for the third time, and each extraction time is calculated from after boiling), the extraction solution is combined, and th...

Embodiment 2

[0046] Example 2 Alcohol extraction method to prepare "Magnolia powder" Chinese medicine extract

[0047] Method 1: Take magnolia, asarum, ligusticum, cohosh, chuanxiong, akebia, fangfeng, notopterygium, licorice and angelica dahurica as raw materials, and extract the raw materials with 65% ethanol as a solvent. The weight ratio of each raw material is magnolia:asarum : Ligusticum: Ligusticum: Cimicifuga: Chuanxiong: Akebia: Fangfeng: Notopterygium: Licorice: Baizhi = 1:1:1:1:1:1:1:1:1:1; Cleanly select the above-mentioned medicinal materials and calculate according to the proportion Weigh 50 kg Magnolias, 50 kg Asarum, 50 kg Ligusticum, 50 kg Cimicifuga, 50 kg Chuanxiong, 50 kg Akebia, 50 kg Fangfeng, 50 kg Notopterygium, 50 kg Licorice and 50 kg Angelica dahurica, 5.0 tons 65% Soak in ethanol for 20min, heat and reflux for extraction twice, each time for 1h (each reflux extraction time starts after boiling), combine the extracts, let stand for 24 hours, filter the supernatan...

Embodiment 3

[0050] Example 3 Water Extraction and Alcohol Precipitation Method to Prepare "Magnolia Powder" Chinese Medicine Extract

[0051] Method 1: Take magnolia, asarum, ligusticum, cohosh, chuanxiong, akebia, fangfeng, notopterygium, licorice and angelica as raw materials, and use water as a solvent to extract the raw materials. The weight ratio of each raw material is magnolia: asarum: Ben: Cimicifuga: Chuanxiong: Akebia: Fangfeng: Notopterygium: Licorice: Angelica dahurica = 1:1:1:1:1:1:1:1:1:1:1; cleanly select the above medicinal materials and weigh them in proportion Magnolia 50kg, Asarum 50kg, Ligusticum 50kg, Cimicifuga 50kg, Rhizoma Chuanxiong 50kg, Akebia 50kg, Fangfeng 50kg, Notopterygium 50kg, Licorice 50kg, Angelica dahurica 50kg, soak in 5.0 tons of water for 20 minutes , heating and extracting 3 times (2h for the first time, 1h for the second time, 30min for the third time, each extraction time is calculated from after boiling), combine the extracts, concentrate the ex...

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Abstract

The invention provides a preparation method and application of traditional Chinese medicine for treating nasosinusitis and bronchitis from 'Xinyi powder formula' (sourced from Yan's Prescription for Succoring the Sick written by Yan Yonghe in the Song Dynasty). The invention provides six preparation methods: (1) water extraction method; (2) alcohol extraction method; (3) water extraction and alcohol precipitation method; (4) water extraction and macroporous resin purification method; (5) alcohol extraction and macroporous resin purification method; and (6) powder mixing method (substance reference of classical prescriptions). By optimizing the process of the extracting, the extract is prepared into various preparations of traditional Chinese medicine, and a main ingredient of an active part is defined. The invention provides 'Xinyi powdery formula' granules and various traditional Chinese medicine extract oral preparations. The prepared product is detected, the active substance basis of the traditional Chinese medicine extract is clear and definite (consists of a plurality of active ingredients of a given ratio), and the content is relatively high.

Description

technical field [0001] The invention relates to the preparation method and application of the Chinese medicine extract of "Magnolia Powder", belonging to the technical field of Chinese medicine. Background technique [0002] Rhinitis is an inflammatory disease of the nasal cavity, which is the inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis of nasal mucosa. Its symptoms are: nasal congestion, nasal congestion is characterized by intermittent, nasal congestion alleviates during daytime, hot weather, labor or exercise, and at night, nasal congestion increases the weight of when sitting quietly or cold, another feature of nasal congestion is alternation. For example, when lying on the side, the nasal cavity on the lower side is blocked, and the nasal cavity on the upper sid...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/14A61P11/00A61P11/02G01N30/02
CPCA61K9/14A61K36/185A61K36/232A61K36/236A61K36/237A61K36/238A61K36/268A61K36/484A61K36/575A61K36/71A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P11/00A61P11/02G01N30/02A61K2300/00
Inventor 严启新曾琪季宗念刘霞刘程程金立伟马安献
Owner 海王百草堂药业有限公司
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