Preparation method of 2-methyl-1-phenyl-1-propanol

Abstract

The invention discloses a preparation method of 2-methyl-1-phenyl-1-propanol, and the method comprises the steps of: adding magnesium chips and additives to an organic solvent under the protection ofan inert gas, heating to reflux, further adding dropwise chlorobenzene for reaction under reflux conditions, and adding dropwise isobutyraldehyde to continue the reaction under the reflux conditions;filtering an obtained reaction solution to recover the magnesium chips, adding an acid solution or a weak acid salt aqueous solution into filtrate for hydrolysis, allowing an obtaining reaction liquidto stand for liquid separation, collecting an organic phase, recovering the organic solvent from the organic phase, and distilling under a reduced pressure to obtain the 2-methyl-1-phenyl-1-propanol.The method has a high raw material utilization rate, the use of a high-cost catalyst is avoided, three wastes are reduced, the production cost is lowered, the product purity is high, the yield is high, and the product has good industrial application value.

Description

technical field [0001] The present invention relates to the preparation method of organic compound 2-methyl-1-phenyl-1-propanol. Background technique [0002] 2-Methyl-1-phenyl-1-propanol is an important fine chemical intermediate, mainly used in photoinitiators (such as photoinitiator 1173, 2-hydroxy-2-methyl-1-phenyl -1-acetone), pharmaceutical intermediates, synthesis of material intermediates, etc. [0003] The preparation methods currently reported for 2-methyl-1-phenyl-1-propanol are: [0004] 1. Patent EP 718265 etc. proposed isobutyrophenone reduction method. This method is synthesized by reducing isobutyrophenone with high-pressure hydrogen under the catalysis of noble metals. The reaction raw materials of this method are difficult to obtain, the use cost of the catalyst is high, and the high-pressure hydrogen operation requires high equipment. [0005] 2. Grignard reagent synthesis method. Literature (Chemical Communications, 2017,53(79):10942-109445) proposes...

AI Technical Summary

Problems solved by technology

The catalyst of this method is difficult to prepare, the required reaction temperature is very low, it is difficult to apply industrially, and the yield is only 85%.

In this method, if the -78°C is adjusted to -20~10°C, the by-products will increase (such as biphenyl, terphenyl), and the reaction selectivity will be greatly reduced.

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