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Photosensitizer concentration detection device, system and method

A technology of concentration detection and photosensitizer, applied in the medical field, can solve the problems of difficult actual concentration, affecting the effect of photodynamic therapy, inaccuracy and so on

Active Publication Date: 2020-12-29
深圳市优迈医学科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the influence of many factors such as the intensity of the excited light, the distance between the light source and the part to be measured, and the angle between the detection end and the object to be measured, the measured fluorescence intensity values ​​are different under different measurement conditions. In the existing method, the detected fluorescence intensity is directly analyzed as the fluorescence intensity of the photosensitizer, that is, the absolute fluorescence intensity, and used to obtain the concentration of the photosensitizer in the lesion. Such a method is not accurate enough and has defects. The measured concentration It is difficult to truly reflect the actual concentration of the photosensitizer in the tissue in real time, thus affecting the effect of photodynamic therapy to a certain extent

Method used

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  • Photosensitizer concentration detection device, system and method
  • Photosensitizer concentration detection device, system and method
  • Photosensitizer concentration detection device, system and method

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Experimental program
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Effect test

Embodiment 1

[0122] refer to figure 1 , figure 1 Shown is a specific embodiment of the photosensitizer concentration detection device provided by the present invention, including a first dichroic mirror 2 and a second dichroic mirror 8, an optical coupler 3, an optical fiber 5, a reflector 6, a first dichroic mirror Both the color mirror 2 and the second dichroic mirror 8 are long-pass dichroic mirrors, which highly reflect light lower than the cut-off wavelength and highly transmit light higher than the cut-off wavelength, and the cut-off wavelengths of the two are λ 1 and lambda 2 , wherein the first dichroic mirror 2 is used to reflect the laser light and the light beam with the same wavelength as the laser light in the signal light, and transmit the collected autofluorescence of the tissue to be treated and the photosensitizer to emit light, and the second dichroic mirror 8 is used to reflect the relatively The short-wavelength autofluorescence of the tissue to be treated transmits t...

Embodiment 2

[0131] refer to figure 2 , figure 2 It is a schematic diagram of the structural improvement of the photosensitizer concentration detection device shown in embodiment 1, specifically, on the basis of the photosensitizer concentration detection device provided in embodiment 1, it also includes a rotating part and a one-dimensional translation stage 18, wherein the rotation The parts include a second rotating part 16, a first rotating part 17 meshed with the second rotating part 16 through a gear, the second rotating part 16 is fixedly connected with the rotating shaft on the motor 15, and rotates synchronously with the rotating shaft, thereby driving the first The rotating part 17 rotates coaxially with the optical fiber 5; the one-dimensional translation stage 18 is slidingly connected with the optical fiber 5, and is used to control the optical fiber 5 to move up and down along the axis direction as shown in the figure;

[0132] Wherein, the second rotating part 16 and the ...

Embodiment 3

[0137] refer to image 3 , image 3 A specific implementation scenario related to the photosensitizer concentration detection device shown in Embodiment 1 of the present invention, that is, a photosensitizer concentration detection system, including a laser light source 1, a photosensitizer concentration detection device, a photodetector 10 and a photodetector 13, and a data acquisition system. Card 11, computer 14.

[0138] Wherein, the photosensitizer concentration detection device is as described in Embodiment 1, between the reflecting mirror 6 and the irradiated tissue to be treated, and the different direction ends of the reflected light beam and the transmitted light beam of the second dichroic mirror 8, respectively Focusing lens 7, focusing lens 9, and focusing lens 12 are provided. In addition, mobile adjustment components are provided, including rotating shaft 15 with motor, gear 16, gear 17 and one-dimensional translation stage 18, specifically at the end of optica...

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Abstract

The invention discloses a detection apparatus, system and method for photosensitizer concentration. The detection apparatus for photosensitizer concentration comprises an optical fiber, a reflector, acoupler, a first dichroic mirror and a second dichroic mirror, wherein one end of the optical fiber is provided with the reflector, and the other end of the optical fiber is connected with the coupler; and the coupler, the first dichroic mirror and the second dichroic mirror are sequentially located on the same straight line. The photosensitizer concentration detection apparatus is applied to thephotosensitizer concentration detection system, can conveniently and accurately capture autofluorescence and the fluorescence signals of a photosensitizer, quickly calculate an integral value and perform concentration analysis, is applicable to a method for calculating the concentration of the photosensitizer based on a fluorescence intensity ratio, greatly improves photodynamic therapy efficiency, reduces cost, and is extremely applicable to real-time in-vivo detection of an endoscope due to small size.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a photosensitizer concentration detection device, system and method. Background technique [0002] The concentration of photosensitizer is a very important parameter in the process of photodynamic therapy. The accurate measurement of the concentration of photosensitizer in the tissues of the body in real time is conducive to improving the effect of photodynamic therapy and realizing precise treatment. [0003] Existing methods for measuring photosensitizer concentration mainly include reflection spectrophotometer and fluorescence spectroscopy based on diffusion approximation theory or modeling based on random walk theory. Due to large errors, they are still in the stage of in vitro measurement and theoretical research. It is difficult to apply to the clinical process; therefore, in the actual photodynamic clinical treatment, due to the inability to accurately obtain the real-tim...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64
CPCG01N21/645G01N2021/6463
Inventor 陈彤范明张治国华剑宇余贤国
Owner 深圳市优迈医学科技有限公司
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