Equipment for preparing lipid nanospheres

Abstract

The invention provides equipment for preparing lipid nanospheres. The primary emulsion preparation part comprises a water phase tank, an oil phase tank and a multi-stage online dispersion machine; anda high-speed shear emulsification head is installed in the water phase tank. According to the equipment provided by the invention, combined emulsification is performed by the multi-stage online dispersing machine and the high-speed shear emulsification head in the equipment, so that stability of a primary emulsion is improved; the water phase tank in the equipment has the functions of water phasepreparation, emulsification and primary-emulsion final product temporary storage, and connection of the water phase tank and the top of the oil phase tank can realize cyclic shearing of a mixed phasein the multi-stage online dispersion machine while the oil phase tank is washed; and the equipment is simplified, reduces adhesion loss of the primary emulsion in the transfer process, and is suitable for industrialized production of the lipid nanospheres.

Description

technical field [0001] The invention relates to the field of chemical equipment, in particular to a device for preparing lipid microspheres, in particular to a device for preparing lipid microsphere colostrum. Background technique [0002] Lipid nanospheres (lipid nanospheres, LN) are based on vegetable oil, outsourced with phospholipid nanospheres, made of oil phase, emulsifier, and water phase, with a particle size in the range of 100-300nm, stable oil-in-water (O / W) dispersion system. The drug can be encapsulated in the oil phase and the phospholipid interface membrane. The drug-loading system requires that the drug has strong fat solubility, or that the encapsulated drug can be converted into an active substance in a rapid and timely manner after reaching the target site to exert its curative effect. Before the site, leakage release rarely occurs. The conventional preparation method is to dissolve the drug and (or) emulsifier in the water phase or the oil phase, heat ...

AI Technical Summary

Problems solved by technology

[0003] CN101496787B discloses a preparation method of lipid microspheres, the preparation method involves the preparation of water phase and the preparation of colostrum, no storage equipment for colostrum is disclosed

The equipment disclosed in the above documents is relatively simple in the preparation of colostrum, and the stability of the prepared colostrum is poor, and the problem of phase separation between the oil phase and the water phase is prone to occur.

In addition, the emulsification head of the above-mentioned equipment is fixed to the middle and lower part of the tank body through the tank top, and there is a technical problem that the emulsification head runs idly during the emptying process, which cannot be adapted to the preparation of special emulsification systems such as microemulsions, nanoemulsions, and lipospheres. Industrial production

Images