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One-step preparation of biocompatible oil-core microcapsules and its application

A biocompatible, step-by-step technology, applied in the field of one-step preparation of biocompatible oil core microcapsules, can solve the problems of difficulty in mass production and long time consumption.

Active Publication Date: 2020-10-27
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention provides a one-step method for preparing biocompatible oil-core microcapsules and its application, which solves the problems of long time-consuming traditional methods, the hydrophilicity of capsule-shell materials, and the problem of microfluidic double emulsions There are difficulties in mass production and the use of toxic organic solvents in template technology. This method is simple and easy to implement, with high packaging efficiency, uniform particle size, and easy mass production

Method used

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  • One-step preparation of biocompatible oil-core microcapsules and its application
  • One-step preparation of biocompatible oil-core microcapsules and its application
  • One-step preparation of biocompatible oil-core microcapsules and its application

Examples

Experimental program
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Effect test

Embodiment 1

[0043] Example 1: Preparation of oil-core microcapsules with uniform size and diameter of about 89 μm

[0044] Refer to attached figure 1 , using the method of the present invention to prepare biocompatible oil-core microcapsules, the specific steps are as follows: (1) Fabrication of the microfluidic device: prepare two circular glass capillaries and one square glass capillary. Ultrasonic cleaning of the above-mentioned glass capillary and drying; using an extensometer to process one end of the circular glass capillary into a tapered shape; rubbing the pointed end of the circular glass capillary with sandpaper to make the port flat; Insert one end of the pointed cone from both ends of the square glass capillary respectively, and center the pointed ends of two round glass capillaries in the square glass capillary, and then fix all the above-mentioned glass capillaries on the glass slide with glue. Capillary glass tube microfluidic device as attached figure 1 As shown, there i...

Embodiment 2

[0048] Example 2: Diffusion rate of oily substance wrapped in oil-core microcapsules as a function of wall thickness.

[0049] (1) 2ml dehydrated alcohol and 5ml lavender essential oil are mixed, then the shellac of 800mg is dissolved in the mixed solution, and this solution is used as new internal phase, and the oil nucleus microcapsule that wraps oily substance is prepared according to embodiment 1;

[0050] (2) 3ml dehydrated alcohol and 5ml lavender essential oil are mixed, then the shellac of 1200mg is dissolved in the mixed solution, and this solution is used as the new internal phase, and the oil nucleus microcapsule that wraps oily substance is prepared according to embodiment 1;

[0051] (3) The wrapped oily substance microcapsules prepared by (1) and (2) are cleaned three times with deionized water, then filtered with a filter screen, and the moisture on the surface of the microcapsules is removed to obtain surface-dried oil core microcapsules ( as attached figure ...

Embodiment 3

[0053] Example 3: Oil core microcapsules achieve sudden release of microcapsules by shaking

[0054] (1) 1ml dehydrated alcohol and 5ml lavender essential oil are mixed, then the shellac of 100mg is dissolved in the mixing solution, obtains internal phase, this solution is used as new internal phase, prepares the oil nucleus that obtains wrapping oil substance by embodiment 1 Microcapsules;

[0055] (2) Prepare oil core microcapsules according to (1) in Example 2, and wash it three times with deionized water;

[0056] (3) Disperse the microcapsules in deionized water, then place them in a test tube, and shake them back and forth to realize the rapid release of the encapsulated oily substance from the microcapsules.

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Abstract

The invention discloses a one-step method for preparation of a biocompatible oil-core microcapsule and application thereof. The method comprises the following steps: lac is selected as a wrapping material, firstly an oily substance and absolute ethyl alcohol are mixed, and the lac is dissolved in the mixed solution; then a microfluidic device is utilized to emulsify the lac mixed solution into uniform-size microdroplets in water; with gradual diffusion of ethanol in the microdroplets into water, the solubility of the lac in the microdroplets is gradually reduced, then the lac is precipitated on the surfaces of the microdroplets and finally is cured to obtain the biocompatible oil-core microcapsule. The method and the application disclosed by the invention have the beneficial effects that one-step preparation of the biocompatible oil-core microcapsule is realized by adopting a microfluidic technology and using single emulsion as a template; the biocompatible oil-core microcapsule is simple in preparation process, high in wrapping efficiency, uniform in particle size and easy in mass production, has good biocompatibility, can wrap different oily substances and control release of theoily substances and have wide application value.

Description

technical field [0001] The invention relates to the field of microcapsules, in particular to a one-step method for preparing biocompatible oil-core microcapsules and an application thereof. Background technique [0002] In the production of cosmetics, drugs and food, some natural active ingredients are often added to increase their functional effects, such as vitamins and antioxidant substances. However, these active ingredients are easily oxidatively decomposed in an environment with oxygen, which limits their applications. By preparing microcapsules with a core-shell structure, the active ingredients can be encapsulated in the microcapsules to protect them from the influence of the environment. Therefore, microcapsule technology is considered to be an effective way to solve this problem. Biocompatible oil-core microcapsules produced on a large scale and with a high encapsulation rate have broad application prospects. [0003] The traditional method to prepare biocompatib...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02B01L3/00
CPCB01J13/02B01L3/502707B01L2300/0838
Inventor 陈东孙泽勇王行政陈然孔琳琳
Owner ZHEJIANG UNIV
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