Continuous device for preparing benzaldehyde midbody and application thereof

A chemical device and technology of benzaldehyde, applied in the field of continuous devices for preparing benzaldehyde intermediates, can solve the problems of poor reaction selectivity and harsh reaction conditions, and achieve the goal of improving reaction selectivity, short reaction time and fast reaction rate Effect

Pending Publication Date: 2018-11-27
ASYMCHEM LIFE SCI TIANJIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The main purpose of the present invention is to provide a continuous device for preparing benzaldehyde intermediates and its application, so as to solve the problems of harsh reaction conditions and poor reaction selectivity in the existing method for preparing benzaldehyde in batches

Method used

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  • Continuous device for preparing benzaldehyde midbody and application thereof
  • Continuous device for preparing benzaldehyde midbody and application thereof
  • Continuous device for preparing benzaldehyde midbody and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] use as figure 1 The shown device prepares benzaldehyde intermediates, and the specific operation process is as follows:

[0055]The prepared 2-bromo-4-fluorobenzaldehyde tert-butyl tetrahydrofuran solution (1.0 equivalent) is output from the raw material liquid supply device 11, and is transported to the first precooling device 40 continuous coil reactor through the second delivery pump 12 , Lithium diisopropylamide (1.1 equivalents) is transported to the second pre-cooling unit 50 by the organolithium reagent supply unit 13 by the third delivery pump 14, and is carried out under the effect of the first jacket outer bath temperature control unit 41 temperature control. The pre-cooled raw material solution and the organic lithium reagent solution are mixed in the continuous lithiation reaction device 10 and undergo a first-stage continuous lithiation reaction to obtain a lithiation product. During the reaction, the raw material solution and the organic lithium reagent ...

Embodiment 2

[0060] The difference from Example 1 is that the reaction temperature of the continuous lithiation reaction is -20° C. and the reaction time is 40 minutes.

Embodiment 3

[0062] The difference from Example 1 is: the reaction temperature of the continuous formylation reaction is -20° C. and the reaction time is 40 minutes.

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Abstract

The invention provides a continuous device for preparing a benzaldehyde midbody and application thereof. The continuous device comprises a continuous lithiation reaction device and a continuous formylation device. The continuous lithiation reaction device is provided with a first feeding inlet and a first discharging outlet, the first feeding inlet is used for adding a reaction raw material and anorganic lithium reagent, and the first discharging outlet is used for continuously discharging a product system obtained after a continuous lithiation reaction; the continuous formylation device is provided with a second feeding inlet, a formylation reagent inlet and a second discharging outlet, the second feeding inlet and the first discharging outlet are communicated so that the product systemobtained after the continuous lithiation reaction can be continuously conveyed into the continuous formylation device, the formylation reagent inlet is used for adding a formylation reagent, and the second discharging outlet is used for continuously discharging the product system obtained after the continuous formylation reaction. By adopting the device, the reaction selectivity is improved, energy consumption is lowered, and meanwhile industrial production is facilitated.

Description

technical field [0001] The invention relates to the field of synthesis of pharmaceutical intermediates, in particular to a continuous device for preparing benzaldehyde intermediates and its application. Background technique [0002] Benzaldehyde intermediates are a common and very important pharmaceutical intermediates. There are many synthesis methods, mainly including toluene oxidation, Vilsmeier reaction formylation of aromatic rings, direct insertion of carbonyls on benzene rings, low-temperature lithiation of aldehyde groups, and so on. Among them, low-temperature lithiation of aldehyde groups is a very classic synthesis method, which can form a very good complementarity with other synthesis methods. [0003] Using the traditional batch reaction process, the process of the low-temperature lithiation aldehyde group method is as follows: the raw materials and solvents are added to the reactor, and stirred and dissolved under the protection of nitrogen. Then, under the p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C67/313C07C69/76
CPCC07C67/313C07F1/02C07C69/76
Inventor 洪浩卢江平丰惜春张欣颜博
Owner ASYMCHEM LIFE SCI TIANJIN
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