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Disposable reaction device, tracer agent synthesizer and tracer agent production method

A reaction device and disposable technology, applied in the field of equipment, can solve problems such as waiting, pollution, waste, etc., and achieve the effects of eliminating pollution, saving time, and improving efficiency

Pending Publication Date: 2018-11-23
HANGZHOU INSPIRED BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the above problems, the present invention provides a disposable reaction device, a tracer synthesizer and a method for producing a tracer, wherein, a disposable reaction device can be removed after use, and there is no cleaning Pipeline and other problems, solve the related problems of waiting, cleaning, waste, pollution, etc., can repeat the synthesis of tracers in a short time, and more in line with the requirements of GMP

Method used

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  • Disposable reaction device, tracer agent synthesizer and tracer agent production method
  • Disposable reaction device, tracer agent synthesizer and tracer agent production method
  • Disposable reaction device, tracer agent synthesizer and tracer agent production method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] as attached figure 1 As shown, the filling process of the non-disposable filling element used in the existing tracer synthesizer is as follows: the reaction bottle 2 moves below the liquid pipeline 1, the liquid pipeline 1 moves down, and the substances required for the reaction are filled into the reaction bottle through the needle a101 2, exhaust gas through the needle b102, the reaction is completed, and the liquid pipeline 1 moves up.

[0038] After the reaction is completed, after the evaporation process, the reaction bottle 2 is moved to the bottom of other liquid pipes, and the step of taking out the contents of the reaction bottle 2 is prepared. figure 2 As shown, the reaction bottle 2 moves below the other liquid pipeline 1, the liquid pipeline 1 moves down, injects gas through the needle b102, and then takes out the content through the needle 1.

[0039] from figure 1 and figure 2It can be seen that the liquid pipeline 1 is composed of a seal 1031 and nee...

Embodiment 2

[0041] The invention provides a disposable reaction device, comprising:

[0042] Disposable reagent bottles can be multiple, respectively loaded with radioactive isotopes, solvents, reagents, and reactants; the contents of the disposable reagent bottles can be sequentially and gradually filled into the disposable reactor 2 through the disposable liquid pipeline 1 .

[0043] The disposable reactor 2, for containing the radioisotope and at least one reagent for reaction, can be sealed with a pierceable member 201 . Although the sealing member 1031 is used for sealing during the reaction, after the pierceable member 201 is added for sealing, the sealing state can be maintained after the liquid pipeline 1 is removed, and the radionuclide radiation is not affected.

[0044] Disposable liquid pipeline 1 includes evaporating element, filling element, retracting element, and mass transfer line; wherein the evaporating element, filling element, and retracting element all include a nee...

Embodiment 3

[0047] The present invention also provides a tracer synthesizer, comprising the above-mentioned disposable reaction device, a connecting piece 3 and a needle c4 , one end of the needle c4 passes through the connecting piece 3 . The upper port of the ring 1032 abuts against the bottom of the connecting piece 3, and the fixing piece 103 is connected to the connecting piece 3 by applying external air pressure, and the fixing piece 103 can be separated from the connecting piece 3 after releasing the air pressure.

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PUM

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Abstract

The invention discloses a disposable reaction device, a tracer agent synthesizer and a tracer agent production method. The disposable reaction device comprises a disposable reagent bottle, a disposable reactor and a disposable liquid pipeline; the disposable reagent bottle is used for loading substances needed by the reaction, and the substances comprise radioactive isotopes, solvents, reagents and reactants; the disposable reactor can be filled with the loaded substances directly or through the disposable liquid pipeline; the disposable reactor is used for containing the radioactive isotopesand at least one reagent to react, and the disposable reactor can be sealed by using a pierced component; and the disposable liquid pipeline comprises an evaporating element, a filling element, a recovering element and a mass transferring pipe line. The disposable reaction device has the beneficial effects that production of the next-batch of tracer agent can be conducted without the need of waiting for 10 half-life period of radioactive decay, the disposable reaction device makes synthesis of the same or different tracer agents be conducted repeatedly in a short term, and thus the research and production efficiency of the tracer agent is greatly improved. The disposable reaction device does not need to be cleaned, and time, manpower and material resources are greatly saved.

Description

technical field [0001] The invention relates to the technical field of instruments, in particular to a disposable reaction device, a tracer synthesizer and a tracer production method thereof. Background technique [0002] Molecular imaging has developed rapidly in recent years. PET-CT (Positron Emission Computed Tomography) uses positron radioactive tracers to detect diseases early in the diagnosis of tumors, heart and nervous system diseases. 18F, 11C, 13N and other radionuclides are produced by a cyclotron, and then these radionuclides are labeled on different chemical substrates through a chemical synthesis module (also called a synthesizer) to synthesize various final tracers for clinical use agent. Because positron radioactive tracers have high radioactivity and short half-life characteristics, they are all fully automatically synthesized by chemical synthesizers using trace reagents. For PET-CT imaging, although many new positron radiopharmaceuticals have been develo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/24B01J19/00G21G4/00
CPCB01J19/0006B01J19/0053B01J19/24G21G4/00B01J2219/00011B01J19/0073B01L3/52B01L2300/044
Inventor 张建中方玉
Owner HANGZHOU INSPIRED BIOTECH INC
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