Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Phase-change mesoporous silicon bionic preparation for targeting controlled release medicine as well as preparation method and application thereof

A mesoporous silicon and preparation technology, which is applied in the field of phase-change mesoporous silicon biomimetic preparations and its preparation, can solve the problems of inability to eliminate cell carriers, incapable of active controlled drug release, and narrow application range, and achieve flexible combination and powerful loading. Medicinal ability, the effect of easy surface modification

Active Publication Date: 2018-11-23
GUANGDONG NO 2 PROVINCIAL PEOPLES HOSPITAL
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these solutions have several problems: one is that the drug cannot be actively controlled release, and the other is that the artificially injected cell carrier cannot be eliminated
But the fatal shortcoming of this solution is that the scope of application is narrow

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Phase-change mesoporous silicon bionic preparation for targeting controlled release medicine as well as preparation method and application thereof
  • Phase-change mesoporous silicon bionic preparation for targeting controlled release medicine as well as preparation method and application thereof
  • Phase-change mesoporous silicon bionic preparation for targeting controlled release medicine as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 Preparation method of drug-loaded phase-change mesoporous silicon biomimetic preparation

[0042] 1. Synthesis of drug-loaded phase-change mesoporous silicon biomimetic preparations

[0043](1) Take by weighing 1.2027g cetyltrimethylammonium bromide (Cetrimonium Bromide, CTAB), add 20mL deionized water and 10mL absolute ethanol, be made into the CTAB solution of 0.11mol / L concentration, in the situation of stirring The silicon dioxide solution was added gradually under the condition of adding 3 mL of ammonia water. After reacting for 5 minutes, 3 mL of 1,4-bis(triethoxysilyl)benzene (1,4-bis(triethoxysilyl)benzene, BTEB) was added and stirred for another 6 h. Centrifuge at 15000rpm / min for 15 minutes to collect the product, and disperse the precipitate in 0.6mol / L Na 2 CO 3 solution, and magnetically stirred in a water bath at 80°C for 30 minutes for etching. The product was collected by centrifugation at 15,000 rpm / min for 15 minutes, washed three times w...

Embodiment 2

[0055] Example 2 Drug-loaded phase-change mesoporous silicon preparations (Cell-DPHs) are used for the treatment of breast cancer mice

[0056] 1. Construction of 4T1 breast cancer mouse model

[0057] (1) The inventor selected Balb / c nude mice as model mice, injected 4T1 cells subcutaneously into the right axillary fat pad of the mice at a ratio of 1 million 4T1 cells per mouse, and measured the tumor every day after 3 days volume.

[0058] (2) When the tumor volume reaches 150mm 3 At that time, the breast cancer model mice were divided into groups and started Cell-DPHs treatment. The inventors randomly divided them into 5 groups according to tumor volume and shape, with 6 rats in each group. The specific groups are as follows: control group (Control group), ultrasound group (US group), ultrasound phase change group (US+Cell-PHs group), drug-loaded phase-change group (Cell-DPHs group) and ultrasound-loaded phase-change group (US+Cell-DPHs group).

[0059] 2. Therapeutic ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a drug-loading phase-change mesoporous silicon bionic preparation. The preparation comprises a macrophage; the macrophage is used for swallowing with hollow mesoporous siliconloaded with a pharmaceutical active component and a perfluorinated compound. The perfluorinated compound is selected from perfluoropentane. The pharmaceutical active component is selected from an anti-inflammatory drug, an anti-tumor drug, a cardiovascular disease drug and a digestion system disease drug. The system provided by the invention has a wide application range and strong targeting performance. The drug-loading phase-change mesoporous silicon bionic preparation can be applied to tumors, autoimmunity diseases, inflammatory diseases and the like, lesion locations with inflammatory changes and diseases capable of attracting the macrophage to be gathered.

Description

technical field [0001] The invention relates to the field of drug targeted and controlled release preparations, in particular to a phase-change mesoporous silicon biomimetic preparation for targeted and controlled release of drugs, its preparation method and application. Background technique [0002] Commonly used clinical drug treatment methods include oral administration, intravenous injection, intravenous infusion, intramuscular injection, etc. However, since most of the drugs are not targeted, the drugs will accumulate in non-target sites and produce different degrees of toxic and side effects. At present, there are roughly the following solutions in the clinical and scientific circles: (1) Preparation of targeted biological agents: such as monoclonal antibodies; (2) Preparation of targeted drug-loaded nanoparticles: such as cisplatin liposomes, etc. ; (3) Preparation of cell-targeting vectors: such as neutrophils, etc. The currently adopted solutions all use passive an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/50A61K47/46A61K47/04A61K47/06A61K45/00A61K31/704A61P35/00A61P29/00A61P9/00A61P1/00
CPCA61K9/5063A61K31/704A61K45/00A61K47/02A61K47/06A61P1/00A61P9/00A61P29/00A61P35/00
Inventor 刘红梅许智莉熊燃易文鸿
Owner GUANGDONG NO 2 PROVINCIAL PEOPLES HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com