A kind of fluorescent gold nanocluster aggregate and preparation method thereof

A fluorescent gold nano-aggregate technology, applied in the fields of chemistry and material science, can solve the problems affecting the application of fluorescent gold nano-clusters, non-dispersion and non-fluorescence of fluorescent gold nano-clusters, and achieve excellent photobleaching resistance, Excellent photoluminescence properties, large Stokes shift effect

Active Publication Date: 2020-09-01
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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AI Technical Summary

Problems solved by technology

However, there are still some problems in the current synthesis methods and properties of fluorescent gold nanoclusters, which need to be further improved.
For example, first, gold nanoclusters with proteins or peptides as stable ligands are expensive, not durable to storage, and require low-temperature storage, and are not suitable for applications that require high stability of gold nanoclusters; second, they require toxicity Larger toxic solvents, additional reducing agents or heating are required, and the requirements for preparation operations are high, and it is easy to generate non-fluorescent species; third, the existing scheme of using alkylthiols to prepare fluorescent gold nanoclusters Most of them need to be carried out in organic solvents, and some need to be heated at higher temperatures, and the prepared fluorescent gold nanoclusters are not dispersed in any solvent, or can only be stably dispersed in some organic solvents, or need to use complex amphiphilic Polymer modification for stable dispersion in aqueous solution
The existence of these aforementioned defects seriously affects the further application of fluorescent gold nanoclusters

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  • A kind of fluorescent gold nanocluster aggregate and preparation method thereof
  • A kind of fluorescent gold nanocluster aggregate and preparation method thereof
  • A kind of fluorescent gold nanocluster aggregate and preparation method thereof

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preparation example Construction

[0025] An aspect of the embodiments of the present invention provides a method for preparing a fluorescent gold nanocluster aggregate, which includes:

[0026] The cationic surfactant and the gold source are mixed and reacted in an organic solvent at 5-35°C to obtain a compound reactant;

[0027] Mixing and reacting the composite reactant with alkylthiol at 5-35°C to obtain an alkylthiol-gold complex solution;

[0028] The alkylthiol-gold complex solution is added into the aqueous solution of the nonionic surfactant to generate fluorescent gold nano cluster aggregates.

[0029] In some typical implementation cases, the preparation method includes:

[0030] Add the organic solution of the cationic surfactant to the organic solution of the gold source and mix and react uniformly at 5-35°C to obtain a complex reactant;

[0031] Slowly add the organic solution of alkylthiol to the composite reactant under vigorous stirring, and mix and react at 5-35°C to obtain the alkylthiol-go...

Embodiment 1

[0058] 1) Add 240 μL of 100 mmol / L tetrahydrofuran solution of didodecyldimethylammonium bromide to 3310 μL of 7.55 mmol / L gold trichloride in tetrahydrofuran under vigorous stirring at 20°C, The color of the solution gradually changed from yellow to brown.

[0059] 2) After 5 minutes, slowly add 180 μL of 500 mmol / L tetrahydrofuran solution of dodecylmercaptan to the solution obtained in 1) dropwise under vigorous stirring. After 10 minutes, the solution gradually becomes colorless.

[0060] 3) Take 100 μL of the above solution, slowly drop it into 900 μL of 20° C. aqueous solution containing 0.001 (volume ratio) Tween 80 under vigorous stirring, and the solution turns milky white.

[0061] 4) Add the above emulsion into a dialysis bag with a molecular weight cut-off of 14,000, and dialyze in deionized water at 20°C for 2 days to remove tetrahydrofuran, etc., to obtain an aqueous solution of stably dispersed gold nanocluster aggregates.

[0062] After testing, the transmissi...

Embodiment 2

[0064] 1) At 5°C, under vigorous stirring, add 240 μL of 100 mmol / L tetrahydrofuran solution of ditetradecyldimethylammonium bromide to 3310 μL of 7.55 mmol / L gold trichloride in tetrahydrofuran solution, The color of the solution gradually changed from yellow to brown.

[0065] 2) After 5 minutes, slowly add 180 μL of a 500 mmol / L tetrahydrofuran solution of undecylmercaptan to the solution obtained in 1) under vigorous stirring. After 10 minutes, the solution gradually becomes colorless.

[0066] 3) Take 100 μL of the above solution, slowly drop it into 900 μL of 5° C. aqueous solution containing 0.001 (volume ratio) Tween 80 under vigorous stirring, and the solution turns milky white.

[0067] 4) Rotating the above emulsion to remove tetrahydrofuran to obtain an aqueous solution of stably dispersed gold nanocluster aggregates.

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Abstract

The invention discloses a fluorescent gold nano-cluster aggregate and a preparation method thereof. The preparation method comprises: mixing and reacting a cationic surfactant and a gold source in an organic solvent to obtain a composite reactant; mixing and reacting the composite reactant with an alkylthiol to obtain an alkylthiol-gold complex compound solution; adding the alkylthiol-gold complex solution into an aqueous solution of a nonionic surfactant to generate fluorescent gold nanocluster aggregates. The excitation peak position of the fluorescent gold nano-cluster aggregate is 200-400 nm, and the emission peak position is 500-800 nm. The invention can prepare fluorescent gold nanocluster aggregates that can be uniformly and stably dispersed in aqueous solution, which can be directly used as fluorescent gold nanoclusters; and it has good photostability, large Stokes shift and near-infrared region The nature of the emission can be applied to fluorescence-related fields, such as light-emitting devices and fluorescence detection.

Description

technical field [0001] The invention relates to a fluorescent gold nano cluster, in particular to a fluorescent gold nano cluster aggregate and a preparation method thereof, belonging to the technical fields of chemistry and material science. Background technique [0002] Fluorescent materials are widely used in biomedical imaging, fluorescence detection, lighting, display, and solar cells, and play an increasingly important role in social development and technological progress. It is of great significance to develop fluorescent materials that are easy to prepare, have good stability and have excellent fluorescent properties. [0003] A metal cluster is a material composed of a few to hundreds of atoms with properties close to molecules. Luminescent metal clusters are a new class of fluorescent materials discovered in recent years, especially fluorescent gold nanoclusters, which are widely used in fluorescence detection and other fields due to their excellent photostability...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/02C09K11/06H01L51/54G01N21/64B82Y30/00B82Y40/00
CPCG01N21/6428C09K11/025C09K11/06B82Y30/00B82Y40/00C09K2211/188H10K85/371
Inventor 裴仁军许丽君
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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