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Anticoagulant textile-based artificial blood vessel material and preparation method thereof

An artificial blood vessel, textile-based technology, applied in the field of artificial blood vessel materials, achieves the effects of low cost, simple process and improved anticoagulation performance

Inactive Publication Date: 2018-11-06
BEIJING INSTITUTE OF CLOTHING TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, only a small amount of heparin-related products have been used clinically so far, and the research on the growth of endothelial cells is still a relatively complex and long-term topic. Therefore, it is urgent to develop new materials for PET surface modification to improve anticoagulant performance

Method used

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  • Anticoagulant textile-based artificial blood vessel material and preparation method thereof
  • Anticoagulant textile-based artificial blood vessel material and preparation method thereof
  • Anticoagulant textile-based artificial blood vessel material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Remove impurities from a large piece of PET / PTT interwoven fabric sample, dry it, and then cut it into small pieces with a size of 10cm*8cm. Prepare 40g / L NaOH, 1g / L1227 solution, put the fabric sample and the solution into the sample dyeing machine according to the bath ratio of 1:50, treat at 90°C for 20min, then take out the fabric sample, rinse it and dry it .

[0039]Polymerize in a mixed solution of ethanol and water. According to the bath ratio, calculate the volume of the solution required in the polymerization experiment, prepare the solution with the volume ratio of ethanol and water as 2:8, pour it into a beaker, and then add pyrrole, the concentration of pyrrole is 0.6mol / L, stir After uniformity, cool down to 0-5°C, put the treated fabric sample into a beaker, add 20ml of FeCl3 solution at the same time, the concentration is 0.3mol / L, and react at 0-5°C for 4 hours. After the reaction is finished, take out the fabric, rinse it, and put it into an oven for...

Embodiment 2

[0041] Remove impurities from a large piece of PET / PTT interwoven fabric sample, dry it, and then cut it into small pieces with a size of 10cm*8cm. Prepare 40g / L NaOH, 1g / L1227 solution, put the fabric sample and the solution into the sample dyeing machine according to the bath ratio of 1:50, treat at 90°C for 20min, then take out the fabric sample, rinse it and dry it .

[0042] Polymerization in a mixed solution of acetonitrile and water. According to the bath ratio, calculate the volume of the solution required in the polymerization experiment, prepare the solution with the volume ratio of acetonitrile and water as 1:9, pour it into a beaker, then add pyrrole, the concentration of pyrrole is 0.6mol / L, stir After uniformity, cool down to 0-5°C, put the fabric sample into a beaker, weigh 10g of ammonium persulfate (APS), dissolve it with 25ml of water, pour it into the beaker, stir evenly, and react at 0-5°C for 4 hours . After the reaction is finished, take out the fabric...

Embodiment 3

[0044] Remove impurities from a large piece of PET / PTT interwoven fabric sample, dry it, and then cut it into small pieces with a size of 10cm*8cm. Prepare 40g / L NaOH, 1g / L1227 solution, put the fabric sample and the solution into the sample dyeing machine according to the bath ratio of 1:50, treat at 90°C for 20min, then take out the fabric sample, rinse it and dry it .

[0045] Polymerization was performed in a cetyltrimethylammonium bromide (CTAB) template. Calculate the volume of the required solution according to the bath ratio, first determine that the molar ratio of CTAB and pyrrole is 1:2, take 11g CTAB and dissolve it in 200ml of distilled water, pour it into a beaker, then add 4.2ml of Py (pyrrole), After stirring evenly, cool down to 0-5°C, weigh 20g of APS and dissolve it with 25ml of distilled water, put the fabric sample into a beaker, then pour APS into the beaker and stir evenly, react at 0-5°C for 4 hours, and the reaction is over Finally, take out the fabri...

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Abstract

The invention relates to an anticoagulant textile-based artificial blood vessel material and a preparation method thereof. The anticoagulant textile-based artificial blood vessel material is characterized in that an anticoagulant polypyrrole (PPy) coating layer is polymerized to the surface of polyester textile, the coating layer is of a micro-nano structure and has good hydrophobic property, andan anticoagulant effect is further improved; meanwhile, some low surface energy matters are further doped into the coating layer, and the anticoagulant effect is further improved. In preparation, firstly, alkali minimization or plasma pretreatment is performed on a polyester material; then, a chemical polymerization technology or electrochemical polymerization technology is utilized to coat pyrrole monomer on the surface of the pretreated material. The artificial blood vessel material disclosed by the invention has the advantages of good anticoagulant effect, simple preparation technology, lowcost, safety and reliability.

Description

technical field [0001] The invention belongs to the technical field of artificial blood vessel materials, in particular to an anticoagulant textile-based artificial blood vessel material of polypyrrole modified polyester fabric. Background technique [0002] Cardiovascular diseases are increasingly threatening human health, and vascular transplantation is an effective method to solve vascular diseases. Textile-based artificial blood vessels have the advantages of simple molding methods and excellent mechanical properties of fabrics. Especially polyester (PET) woven blood vessels have been well used in large-diameter artificial blood vessels. However, PET woven small-caliber artificial blood vessels with a diameter of less than 6 mm are prone to thrombosis or abnormal intimal hyperplasia, resulting in low long-term patency after transplantation, which cannot meet the needs of clinical applications. The results of the interface interaction between tissue and blood, such as th...

Claims

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Application Information

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IPC IPC(8): D06M15/37D06M11/38D06M13/463C08G73/06A61L27/50A61L27/18A61L27/34A61L27/54A61L33/00A61L33/06D06M101/32
CPCA61L27/18A61L27/34A61L27/50A61L27/507A61L27/54A61L33/0041A61L33/068A61L2300/216A61L2300/42A61L2300/606A61L2430/22C08G73/0611D06M11/38D06M13/463D06M15/37D06M2101/32C08L67/02C08L79/04
Inventor 陈莹王鸿达张勤黄丽君
Owner BEIJING INSTITUTE OF CLOTHING TECHNOLOGY
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