Anti-C5 full-human derived single-chain antibody C5B3 and application thereof
A single-chain antibody, fully human technology, applied in the field of bioengineering, can solve the problems of complex humanization process, life-threatening, allergic reactions, etc., and achieve the effect of inhibiting the formation of membrane attack complexes and reducing damage
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[0031] Specific embodiments of the present disclosure will be described in detail below in conjunction with the accompanying drawings. It should be understood that the specific embodiments described here are only used to illustrate and explain the present disclosure, and are not intended to limit the present disclosure.
[0032] The present invention is based on a fully human scFv single-chain antibody library, and obtains a fully human anti-C5 single-chain antibody by screening a phage display method, avoiding the HAMA reaction, and has carried out functional verification; it is different from the previous anti-C5 single-chain antibody Compared with the CDR region of the chain antibody, the difference is quite large, and it is a brand new monoclonal antibody drug. The invention is a single-chain antibody with a size of about 30KD and a small protein molecular weight, which is easier to enter the lesion and take effect, especially for brain diseases, which can pass through the...
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