System and method for quantitatively estimating HIFU (High Intensity Focused Ultrasound) damage viscoelasticity through pulsed acoustic radiation force shear waves monitored by laser Doppler

Abstract

The invention discloses a system and a method for quantitatively estimating HIFU (High Intensity Focused Ultrasound) damage viscoelasticity through pulsed acoustic radiation force shear waves monitored by a laser Doppler. According to the system, a synchronizing signal control system is connected with an arbitrary waveform generator and a high-speed data acquisition card, and the arbitrary waveform generator is connected with a high intensity focused ultrasound transducer by virtue of a power amplifier and an impendence-matching network; the high intensity focused ultrasound transducer is arranged outside a water tank, and detected imitated body tissues are arranged inside the water tank and connected with one three-dimensional movement device; laser Doppler equipment is arranged outside the water tank and connected with another three-dimensional movement device; and the output end of the laser Doppler equipment is connected with a PC (Personal Computer) via the high-speed data acquisition card. According to the system disclosed by the invention, single pulse acts on the imitated body tissues, so that ultrasonic action time and ultrasonic radiation dose can be effectively reduced;the acoustic radiation force shear waves are tracked by utilizing laser Doppler, the wave velocity and attenuation coefficient of the shear waves are obtained by using a 2D-FT algorithm, the shearingmodulus of elasticity and shear viscosity coefficient are further analyzed, and the defects of the conventional SDUV (Shearwave Dispersion Ultrasound Vibrometry) method are overcome.

Description

Technical field [0001] The invention belongs to the technical field of biomedical ultrasonic measurement, and particularly relates to an experimental system and method for using a laser Doppler of a 2D-FT algorithm to monitor acoustic radiation force shear waves to estimate high-intensity focused ultrasound (HIFU) damage viscoelasticity. Background technique [0002] High intensity focused ultrasound (HIFU) is a non-invasive, safe and efficient treatment method. In order to effectively guide the treatment focus of HIFU and control the ultrasound treatment dose, real-time monitoring and evaluation of the HIFU treatment process is required . During HIFU treatment, tissue protein denatures to form irreversible coagulation necrosis. This process will change the mechanical properties of the tissue. Therefore, the mechanical properties of the tissue target area under the action of HIFU can be changed, especially the viscoelastic properties. Real-time monitoring to evaluate the treatme...

AI Technical Summary

Problems solved by technology

The present invention uses a single pulse to act on the phantom tissue, and applies the laser Doppler technology to the monitoring of shear waves inside the transparent phantom, so as to overcome the shortcomings of using continuous waves to act on the phantom tissue in the prior art, and realizes the laser A breakthrough in the application of Doppler technology to the interior of transparent phantoms. At the same time, the use of 2D-FT-based algorithms overcomes the inability to measure the attenuation coefficient of the traditional SDUV method and greatly improves the measurement efficiency.

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