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A long-acting sustained-release cardiovascular coating material with dual functions of anti-calcification and anti-proliferation and its preparation method

A coating material, cardiovascular technology, applied in coatings, pharmaceutical formulations, prostheses, etc., can solve the problems of easy sudden release of drugs, low drug loading, etc., achieve high research and application value, and enhance the effect of mechanical properties

Active Publication Date: 2020-03-10
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of the above prior art, the present invention provides a preparation method of a long-acting sustained-release cardiovascular coating material with both anti-calcification and anti-proliferation functions and the cardiovascular coating material prepared by this method, to solve the problem of hydrophobicity Technical issues of low loading of anti-proliferative and anti-calcific drug in the coating and easy burst release of the drug

Method used

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  • A long-acting sustained-release cardiovascular coating material with dual functions of anti-calcification and anti-proliferation and its preparation method
  • A long-acting sustained-release cardiovascular coating material with dual functions of anti-calcification and anti-proliferation and its preparation method

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preparation example Construction

[0028] Aiming at the problems that cardiovascular stent materials are easy to cause restenosis at the implantation site after being implanted into the human body, and the amount of anti-calcification and anti-proliferation drugs of organic coating materials in the prior art is too low and the drug release rate is too fast, the present invention proposes a A new coating material preparation method, which introduces calcification drugs and anti-proliferation drugs into the coating material through layer-by-layer self-assembly technology, and binds the drug-loaded micelles on the membrane through various intermolecular interactions. To achieve the purpose of slow drug release. The preparation method mainly comprises the following steps:

[0029] 1), preparation of polycation electrolyte solution

[0030] The polyanolyte among the present invention preferably adopts the polyamino compound of catechol group modification, and this is because catechol compounds are easily oxidized a...

Embodiment 1

[0044] A method for preparing a long-acting sustained-release cardiovascular coating material with dual functions of anti-calcification and anti-proliferation, which is realized based on mussel bionics and phenylboronic acid modification, comprising the following steps:

[0045] A. Use 3,4-dihydroxybenzaldehyde to modify dimethyl ammonium chloride to obtain positively charged biomacromolecules modified by catechol derivatives. During modification, dimethyl ammonium chloride and 3,4-dimethyl ammonium chloride The molar ratio of hydroxybenzaldehyde is 2:1; after the modification is completed, the modification is configured into a solution with a concentration of 10 mg / ml and pH=6; the solution is used as a polycation electrolyte component for layer-by-layer self-assembly;

[0046] B, preparing negatively charged heparin into a solution with a concentration of 10 mg / ml and pH=6, which is used as a layer-by-layer self-assembled polyanion electrolyte component;

[0047] C. Weigh 2 ...

Embodiment 2

[0053] A preparation method for a long-acting sustained-release cardiovascular coating material with dual functions of anti-calcification and anti-proliferation, which is realized based on mussel bionics and phenylboronic acid modification, including the following steps:

[0054] A. Utilize 3,4-dihydroxybenzaldehyde to modify polydiallyl polyhexyl violet nitrile to obtain positively charged biological macromolecules modified by catechol derivatives. During modification, polydiallyl polyhexyl violet nitrile The molar ratio to 3,4-dihydroxybenzaldehyde is 1:1; after the modification is completed, the modification is configured into a solution with a concentration of 2mg / ml and pH=6; this solution is used as a polycation electrolyte component for layer-by-layer self-assembly ;

[0055] B, preparing negatively charged heparin into a solution with a concentration of 2 mg / ml and pH=6, which is used as a layer-by-layer self-assembled polyanion electrolyte component;

[0056] C. Weig...

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Abstract

The invention discloses a long-acting sustained-release cardiovascular coating material with dual functions of anti-calcification and anti-proliferation and a preparation method thereof; the preparation method is as follows: firstly polishing, cleaning and drying the base material to be modified and modified ; Then place the treated substrate in dopamine solution, react at 10-30°C for 0.5-2h; then put the reacted substrate into biomacromolecule solution, heparin solution and biomacromolecule solution in sequence , respectively soaked for 10 minutes, and then transferred to drug-loaded micelles for soaking for 20 minutes; finally, the soaking step was repeated 1 to 30 times to obtain the final product. Using this method, a cardiovascular coating material with excellent mechanical properties and sustained drug release can be prepared. By loading the drug-loaded micelles with anti-vascular calcification drugs and anti-vascular smooth muscle hyperplasia drugs, it can effectively support the cardiovascular system. Anti-calcification and anti-proliferation properties of vascular stent coating materials.

Description

technical field [0001] The invention belongs to the technical field of medical materials, in particular to a long-acting slow-release cardiovascular coating material with dual functions of anti-calcification and anti-proliferation and a preparation method thereof, which can be used for cardiovascular materials (such as stents, artificial small blood vessels, artificial Valve) and other aspects to construct a modified coating with anti-calcification and anti-proliferation functions. Background technique [0002] After cardiovascular implant materials enter the human body, some unfavorable interactions between tissues and materials will occur in contact with tissues. When the materials are implanted, endothelial damage will inevitably be caused, and the growth rate of smooth muscle cells is faster than that of endothelial cells. Cells are too late to repair, smooth muscle cell proliferation, blood lipid deposition, calcium deposition, etc., can easily lead to restenosis at the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/54A61L27/34A61L27/28A61L31/16A61L31/10A61L31/08
CPCA61L27/28A61L27/34A61L27/507A61L27/54A61L31/08A61L31/10A61L31/16A61L2300/216A61L2300/232A61L2300/416A61L2300/45A61L2300/602A61L2300/606A61L2300/626A61L2420/02C08L5/08C08L77/04C08L39/02
Inventor 王云兵陆奖罗日方庄伟华李高参
Owner SICHUAN UNIV
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