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Application of MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) and/or derivatives thereof in preparation of blood glucose control medicines

A technology of blood sugar control and derivatives, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems such as no reports on blood sugar control of MPTP and its derivatives, and achieve the improvement of insulin resistance and control. The effect of blood sugar levels

Active Publication Date: 2018-11-02
GUANGDONG GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] After searching the literature and patents at home and abroad, there is no report about MPTP and its derivatives in blood sugar control

Method used

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  • Application of MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) and/or derivatives thereof in preparation of blood glucose control medicines
  • Application of MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) and/or derivatives thereof in preparation of blood glucose control medicines
  • Application of MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) and/or derivatives thereof in preparation of blood glucose control medicines

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Embodiment 1

[0032] 1. Materials

[0033] 1. Experimental animals

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Abstract

The invention discloses application of MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) and / or derivatives thereof in preparation of blood glucose control medicines. The inventor discovers that MPTP is capable of lowering the blood glucose level in vivo and controlling the insulin level, which indicates that the compound is capable of effectively controlling blood glucose. The data supports thefollowing hypothesis, namely the MPTP has an effect of controlling the blood glucose level, and by performing salifying modification, esterification modification, amidation modification, ring-openingmodification or ring formation modification and other chemical modification measures on certain functional groups of compounds shown as a formula (I), the toxic effects can be reduced or eliminated,so that the MPTP and / or the derivatives thereof can be applied to treating type 1 diabetes mellitus, type 2 diabetes mellitus or other blood glucose level increase diseases.

Description

technical field [0001] The present invention relates to the new application of MPTP and / or its derivatives, in particular to the application of MPTP and / or its derivatives in the preparation of blood sugar control drugs. Background technique [0002] The normal value of fasting blood glucose is below 6.1mmol / L, and the normal value of blood glucose two hours after a meal is below 7.8mmol / L. If it is higher than this range, it is called hyperglycemia. Under normal circumstances, the human body can ensure the balance between the source and outlet of blood sugar through the two major regulatory systems of hormone regulation and nerve regulation, so that blood sugar can be maintained at a certain level. However, under the joint action of genetic factors (such as family history of diabetes) and environmental factors (such as unreasonable diet, obesity, etc.), the two major regulatory functions are disturbed, and blood sugar levels will rise. Diabetes mellitus is a group of metab...

Claims

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Application Information

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IPC IPC(8): A61K31/4418A61P3/10A61P5/50
CPCA61K31/4418A61P3/10A61P5/50
Inventor 王丽娟高玉元张玉虎聂坤谢泗芬郭曼莉马桂贤代成波张雄王丽敏赵洁皓王硕
Owner GUANGDONG GENERAL HOSPITAL
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