Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel antiviral medicines and application thereof

A drug and virus technology, applied in the field of virus treatment, can solve problems such as high cost and long research and development cycle

Pending Publication Date: 2018-11-02
EAST CHINA UNIV OF SCI & TECH
View PDF1 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To develop different drugs for different viruses, the development cycle is long and the cost is high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel antiviral medicines and application thereof
  • Novel antiviral medicines and application thereof
  • Novel antiviral medicines and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1. Activity Evaluation

[0052] Activity test for inhibiting virus replication at the cellular level

[0053] The present inventors tested the activity of the compounds of the present invention in inhibiting the replication of each virus at the cellular level as described in the "Materials and Methods" section above.

[0054] The half maximal inhibitory concentration IC of compound of the present invention to H3N2 (influenza virus) in host cell MDCK 50 and drug half toxic concentration TC 50

[0055] compound

IC 50 (uM)

TC 50 (uM)

SI(TC 50 / IC 50 )

Leflunomide

18

>50

>2.8

Teriflunomide

2.5

>50

>25

Buquina

1

>50

>50

[0056] The half inhibitory concentration IC of the compound against RSV (human respiratory syncytial virus) in the host cell Vero (African green monkey kidney cells) 50 and drug half toxic concentration TC 50

[0057] compound

IC 50 (uM)

TC 50...

Embodiment 2

[0066] Example 2. Combination with other antiviral drugs

[0067] The present inventor has further tested leflunomide, teriflunomide, buquinar and other antiviral drugs of the prior art, oseltamivir, ribavirin, zanamivir, Tamiflu, lanimide The combined use of Weiwei or Peramivir.

[0068] It was found that the combination of leflunomide, teriflunomide, and buquinar with these antiviral drugs can produce better therapeutic effect; among them, the therapeutic effect of combination with oseltamivir is relatively better.

[0069] discuss:

[0070] Through in vitro cell experiments and in vivo mouse challenge experiments, the compounds of the present invention have better anti-influenza virus, anti-hand-foot-mouth virus, anti-dengue fever virus and other acute infection virus capabilities. Compared with existing antiviral drugs, For example, the combination of oseltamivir can increase the survival rate of H7N9 severely infected mice by 25%. It has the prospect of being developed...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses application of leflunomide, teriflunomide, brequinar and derivatives thereof to treatment of virus infection, especially RNA virus infection. RNA viruses include but are not limited to influenza viruses, respiratory syncytial viruses, hand, foot and mouth viruses (EV71), dengue viruses (type-2 dengue viruses), Zika viruses and Japanese encephalitis viruses. The medicines have broad-spectrum and excellent antiviral activity and have relatively low toxicity to normal cells.

Description

technical field [0001] The present invention relates to the field of medicinal chemistry; Specifically, leflunomide, teriflunomide, buquinal and derivatives thereof of the present invention are used in the preparation of drugs for the treatment of viruses, such as RNA virus infections and in the treatment of viruses, such as RNA virus infections in the application. Background technique [0002] Diseases caused by acute viral infections are an important threat to public health security. These viruses include not only the well-known influenza virus (avian influenza virus), hand-foot-mouth virus, and dengue virus, but also some new and sudden new virulent viruses such as Ebola. Viruses, coronaviruses and other RNA viruses. The diseases caused by acute viral infection all have some common characteristics: 1) short course of disease (1-2 weeks), rapid development (rapid development within a few days after onset); 2) severe illness and even death are easily caused in high-risk gr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/42A61K31/277A61K31/215A61K31/47A61K45/06A61P31/14
CPCA61K31/215A61K31/277A61K31/42A61K31/47A61K45/06A61K2300/00Y02A50/30
Inventor 李洪林徐可赵振江熊芮
Owner EAST CHINA UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com