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Preparation process of ropivacaine mesoporous-bioactive-glass composite microspheres

A technology of bioactive glass and composite microspheres, which can be used in drug combinations, organic active ingredients, microcapsules, etc., and can solve problems such as lack of research.

Active Publication Date: 2018-11-02
无锡市锡山人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But so far there is no relevant research on the ropivacaine sustained-release drug delivery system using MBG as the carrier.

Method used

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  • Preparation process of ropivacaine mesoporous-bioactive-glass composite microspheres
  • Preparation process of ropivacaine mesoporous-bioactive-glass composite microspheres
  • Preparation process of ropivacaine mesoporous-bioactive-glass composite microspheres

Examples

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Effect test

Embodiment 1

[0032] Example 1: The specific preparation method of the ropivacaine mesoporous bioactive glass composite microspheres provided in this example is as follows:

[0033] Step 1: SiO 2 Preparation of colloidal crystal templates

[0034] Monodisperse SiO 2 Preparation of Microspheres: Using A method for the preparation of monodisperse SiO by an alkaline hydrolysis process of ethyl orthosilicate (TEOS) 2 microsphere suspension. Weigh 251.2g absolute ethanol, 118.25g deionized water and 34g NH 3 ·H 2 O was placed in an Erlenmeyer flask, and after mixing evenly under magnetic stirring, 27.7g TEOS was added, and magnetic stirring was continued for 3h to obtain SiO 2 Suspension of particles.

[0035] SiO 2 Preparation of colloidal crystal template: firstly, the SiO prepared above 2 The suspension of particles was rotovaped to remove excess solvent, which was then placed in a flat-bottomed vessel and centrifuged to remove excess solvent, resulting in large, disordered SiO 2 c...

Embodiment 2

[0044] Example 2: The preparation method is the same as in Example 1, except that in step 5, the PEG with a molecular weight of 6,000 is replaced with PEG with a molecular weight of 10,000, and the pressurized plane is made of glass. The pressurized pressure was 0.054 MPa.

Embodiment 3

[0045] Example 3: The preparation method is the same as that of Example 1, except that in step 5, the PEG with a molecular weight of 6,000 is replaced with PEG with a molecular weight of 20,000, and ceramics are used for the pressing plane. The pressurized pressure is 0.08 MPa.

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Abstract

The invention relates to a preparation process of ropivacaine mesoporous-bioactive-glass composite microspheres. The preparation process comprises the following steps: (1) preparation of a SiO2 colloidal crystal template; (2) preparation of a reverse colloidal crystal template; (3) preparation of MBGs; (4) loading of drugs in the MBGs; (5) preparation of composite microspheres. The step (5) comprises the specific steps: firstly dispersing the MBGs and drug-loaded-MBGs powder to be uniform, flatly laying on a flat and clean plane with enough strength, then pressing another flat and clean surface with enough hardness on the MBGs and the drug-loaded-MBGs powder to carry out pressing, adjusting pressing pressure well, then dropwise adding chloroform solution of PEG and PLA-PEG around the MBGsand the drug-loaded-MBGs powder, wetting and maintaining ventilation under normal temperature till chloroform is completely volatilized.

Description

technical field [0001] The invention relates to the technical field of preparation of sustained-release medicines, in particular to a preparation process of ropivacaine mesoporous bioactive glass composite microspheres Background technique [0002] Pain is an unpleasant sensory and emotional experience resulting from tissue damage or potential tissue damage. Acute pain is often related to surgical trauma, tissue damage, or certain disease states, and the duration is usually less than one month, which belongs to nociceptive pain. Postoperative pain refers to the acute pain that occurs immediately after surgery, and usually lasts no more than 7 days. In traumatic thoracic surgery and joint replacement that requires long-term functional exercise, sometimes analgesia needs to last for several weeks. Postoperative pain in limbs has a severe negative impact on the quality of postoperative recovery and functional exercise of patients. For persistent pain after surgery, there are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K31/445A61K47/34A61K9/16A61K47/02A61P23/00A61P29/00
CPCA61K9/1611A61K9/5031A61K9/5089A61K31/445A61K47/02A61P23/00A61P29/00
Inventor 刘清仁范健纪立军
Owner 无锡市锡山人民医院
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