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Ginkgo biloba and wolfberry compound oral liquid for preventing and/or treating cardiovascular and cerebrovascular diseases and preparation method thereof

A technology of ginkgo biloba and oral liquid, applied in cardiovascular system diseases, nervous system diseases, medical raw materials derived from Ginkgo biloba, etc., can solve the problem of limited bioavailability of tablets and capsules, rare combination of ginkgo biloba and wolfberry, The improvement of cardiovascular and cerebrovascular diseases is not effective, and the effect of reducing blood viscosity, good water solubility and high clarity is achieved.

Active Publication Date: 2022-03-08
ZHEJIANG XINCHANG NATURAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art, the cardiovascular and cerebrovascular health products containing Ginkgo biloba extract and Lycium barbarum extract are mainly tablets and capsules, and the dosage form of oral liquid is very rare, but the bioavailability of tablets and capsules is limited. The improvement effect is not good; and in the patent, the combination of ginkgo biloba and wolfberry is rare

Method used

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  • Ginkgo biloba and wolfberry compound oral liquid for preventing and/or treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Ginkgo biloba and wolfberry compound oral liquid for preventing and/or treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Ginkgo biloba and wolfberry compound oral liquid for preventing and/or treating cardiovascular and cerebrovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1, the preparation method 1 of ginkgo leaf wolfberry compound oral liquid

[0043] The preparation method of the ginkgo leaf wolfberry compound oral liquid provided by the present embodiment comprises the following steps:

[0044] (1) Preparation of water-soluble Ginkgo biloba extract

[0045] Take 2000 grams of fat-soluble ginkgo biloba extract, add 15 liters (1500 ml) of 22% ethanol at 50 ° C and stir to dissolve it, let it cool and place it overnight, filter to obtain filtrate A, and dry the filter residue for retention. Filtrate A is placed in a decompression tank for decompression, and the ethanol is recovered until there is no alcohol smell. In the process of recovering ethanol, 10 liters (10000 ml) of hot water at 52°C must be continuously added to the filtrate A, so that the weight content of the solid accounts for the solvent. The volume fraction of Ginkgo biloba was controlled at 7%, left overnight at room temperature, and filtered to obtain filtra...

Embodiment 2

[0054] Embodiment 2, the preparation method of ginkgo leaf wolfberry compound oral liquid

[0055] The preparation method of the ginkgo leaf wolfberry compound oral liquid provided by the present embodiment comprises the following steps:

[0056] (1) Preparation of water-soluble Ginkgo biloba extract

[0057] Take 2000 grams of fat-soluble ginkgo biloba extract, add 15 liters (15000 ml) of 28% ethanol at 50 ° C and stir to dissolve it, let it cool and place it overnight, filter to obtain filtrate A, and dry the filter residue for retention.

[0058] Filtrate A is placed in a decompression tank for decompression, and the ethanol is recovered until there is no alcohol smell. In the process of recovering ethanol, 10 liters (10000 ml) of hot water at 52°C must be continuously added to the filtrate A, so that the weight content of the solid accounts for the solvent. The volume fraction of Ginkgo biloba was controlled at 9%, left overnight at room temperature, and filtered to obtai...

Embodiment 3

[0067] Embodiment 3, the preparation method of ginkgo leaf wolfberry compound oral liquid

[0068] The preparation method of the ginkgo leaf wolfberry compound oral liquid provided by the present embodiment comprises the following steps:

[0069] (1) Preparation of water-soluble Ginkgo biloba extract

[0070] Take 2000 grams of fat-soluble Ginkgo biloba extract, add 15 liters (15000 ml) of 25% ethanol at 50 ° C and stir to dissolve it, let it cool and place it overnight, filter to obtain filtrate A, and dry the filter residue for retention. Filtrate A is placed in a decompression tank for decompression, and the ethanol is recovered until there is no alcohol smell. In the process of recovering ethanol, 10 liters (10000 ml) of hot water at 52°C must be continuously added to the filtrate A, so that the weight content of the solid accounts for the solvent. The volume fraction of Ginkgo biloba was controlled at 7%, left overnight at room temperature, and filtered to obtain filtrat...

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Abstract

The invention discloses a ginkgo leaf wolfberry compound oral liquid for preventing and / or treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The preparation method of the ginkgo leaf wolfberry compound oral liquid provided by the present invention comprises the following steps: (1) preparing the water-soluble ginkgo leaf extract; (2) preparing the wolfberry extract; (3) preparing the ginkgo leaf wolfberry compound oral liquid; 4) Prepare the compound oral liquid of ginkgo leaf and wolfberry. The compound oral liquid of ginkgo leaf and wolfberry provided by the invention can improve cardiovascular and cerebrovascular diseases, and meanwhile, the content of ginkgolic acid is less than 1 ppm. The ginkgo leaf wolfberry compound oral liquid prepared according to the method of the present invention has significant improvement effects on hypoxia, cardiovascular and cerebrovascular diseases, especially myocardial ischemia, prevention of myocardial infarction, and reduction of blood viscosity; Ginkgo biloba extract and Lycium barbarum extract The combination of drugs is more scientific and reasonable, and the two have better complementary and synergistic effects, and have obtained relatively satisfactory clinical verification.

Description

technical field [0001] The invention belongs to the field of oral traditional Chinese medicine preparations, in particular to ginkgo leaf and wolfberry compound oral liquid for preventing and / or treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases are collectively referred to as cardiovascular and cerebrovascular diseases, and are the number one killer of middle-aged and elderly people. Cardiovascular and cerebrovascular diseases have the characteristics of "high morbidity, high disability rate, high mortality, high recurrence rate, and many complications", that is, "four highs and one high". At present, there are more than 270 million patients with cardiovascular and cerebrovascular diseases in my country , nearly 3 million people die of cardiovascular and cerebrovascular diseases in my country every year. [0003] Ginkgo bilobal (Ginkgo bilobal) is an ancient plant t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/815A61P9/00A61P25/00A61K36/16
CPCA61P9/00A61P25/00A61K9/0095A61K36/16A61K36/815A61K2236/333A61K2236/331A61K2236/51A61K2300/00
Inventor 孙载明孙思南
Owner ZHEJIANG XINCHANG NATURAL HEALTH PROD CO LTD
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