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Application of mesenchymal stem cells combined with platelet-rich plasma in preparation of medicine for promoting rotator cuff injury tendon-bone complex concrescence

A platelet-rich plasma and stem cell technology, applied in the field of rotator cuff tendon and bone healing, can solve problems such as apoptotic growth factors, and achieve the effects of promoting healing, enhancing anti-apoptotic ability and improving healing ability.

Inactive Publication Date: 2018-10-16
HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above studies respectively verified the effectiveness of various methods for promoting tendon-bone healing, but at the same time exposed the limitations of various methods, such as the rapid apoptosis after BMSC transplantation, the early degradation of growth factors released by PRP, etc.

Method used

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  • Application of mesenchymal stem cells combined with platelet-rich plasma in preparation of medicine for promoting rotator cuff injury tendon-bone complex concrescence
  • Application of mesenchymal stem cells combined with platelet-rich plasma in preparation of medicine for promoting rotator cuff injury tendon-bone complex concrescence
  • Application of mesenchymal stem cells combined with platelet-rich plasma in preparation of medicine for promoting rotator cuff injury tendon-bone complex concrescence

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1. Effect of PRP on gene expression, differentiation and anti-apoptotic ability of MSCs

[0043] (1) Experimental animals

[0044] 27 healthy adult New Zealand white rabbits, male or female, body weight (3.0±0.5) kg, rabbits were fed with common feed, 24h cycle light, free to eat and drink, all animals had no trauma, infection and deformity in the operation area, and no other Systemic diseases, all operating procedures comply with animal experiment guidelines. Experimental animals were provided by the Animal Experiment Center of our school.

[0045] (2) Acquisition of autologous peripheral blood BMSCs

[0046] ① Animal treatment: three experimental animals in the first group were subcutaneously injected on the back with a dose of granulocyte colony-stimulating factor (G-CSF) 10 μ g / (kg·d) for 5 consecutive days, and injected twice a day;

[0047] ②Cell extraction and separation: On the 6th day after cytokine mobilization, about 5 mL of blood was drawn from the experi...

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Abstract

The present invention discloses an application of mesenchymal stem cells combined with platelet-rich plasma in preparation of a medicine for promoting rotator cuff injury tendon-bone complex concrescence. The application uses the combined preparation of the mesenchymal stem cells (BMSCs) and the platelet-rich plasma (PRP) for the medicine for promoting promoting rotator cuff injury tendon-bone complex concrescence, and the anti-apoptotic ability of the mesenchymal stem cells is enhanced, the degradation velocity of growth factors of the platelet-rich plasma is released, and the mesenchymal stem cells and the platelet-rich plasma can mutually promote the expression of the growth factors, which are beneficial to the concrescence of tendon bone, of the mesenchymal stem cells and the platelet-rich plasma.

Description

technical field [0001] The invention belongs to the technical field of tendon-bone healing of the rotator cuff, and specifically relates to the application of mesenchymal stem cells combined with platelet-rich plasma in the preparation of medicines for promoting the healing of tendon-bone complexes with rotator cuff injuries. Background technique [0002] The shoulder joint is the joint with the largest range of motion in the human body, and it is also the most unstable joint. The rotator cuff (Rotator cuff) plays an important role in maintaining the stability of the glenohumeral joint and participating in its movement. unique nature. The rotator cuff differs from typical synapses in that it is a tendon-bone complex composed of tendons from the supraspinatus, infraspinatus, subscapularis, and teres minor (Bales C, Anderson K. Arthroscopic double-rowrepair of full thickness rotator cuff tears using a suture bridge technique. Oper Tech Sports. Med, 2007, 15(3): 144-149.). Ro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61P19/08A61K35/16
Inventor 胡云根
Owner HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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