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Application of melanotropin hormone recombinant toxin in preparation drugs treating colon cancer

A technology for melanotropin-stimulating and colon cancer, which is applied in the field of medicine and achieves good application prospects

Active Publication Date: 2018-10-09
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the first choice for the treatment of colon cancer is surgical treatment. The tumor tissue is removed by surgery. However, due to the possible presence of micro-metastases, there is still a high probability of recurrence and metastasis after tumor tissue resection, so most patients with colon cancer still need to undergo surgery. chemotherapy and radiation to reduce recurrence

Method used

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  • Application of melanotropin hormone recombinant toxin in preparation drugs treating colon cancer
  • Application of melanotropin hormone recombinant toxin in preparation drugs treating colon cancer
  • Application of melanotropin hormone recombinant toxin in preparation drugs treating colon cancer

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Embodiment Construction

[0017] Application of melanotropin-stimulating recombinant toxin in preparation of medicament for treating colon cancer.

[0018] The nucleotide sequence of the coding gene of the melanotropin recombinant toxin is described in SEQ ID No.1.

[0019] The amino acid sequence of the melanotropin recombinant toxin is described in SEQ ID No.2.

[0020] The melanotropin recombinant toxin can target the melanocortin receptor-1 (MC1R), and specifically capture and kill colon cancer cells with high expression of the receptor.

[0021] The colon cancer cells include HT29 colon cancer cell line and HCT-116 colon cancer cell line.

[0022] In the following, the present invention will be further described by analyzing the content of MClR in cells and detecting the killing activity of cells.

[0023] Using the prokaryotic expression system, the high-efficiency expression of α-MSH-PE38 was screened KDEL For the recombinant strain, expand the culture volume to 1L, SOB medium, shake culture ...

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Abstract

The invention relates to an application of melanotropin hormone recombinant toxin in preparation drugs treating colon cancer, and belongs to medicine field. The nucleotide sequencing of the encoding gene of the melanotropin hormone recombinant toxin is expressed as SEQ ID No. 1, the melanotropin hormone recombinant toxin is capable of treating melanocortin receptor 1 as a therapeutic target, specifically capturing and killing the high expressed colon cancer cells which include colon cancer cell line HT29 and colon cancer cell line HCT-116 of the receptor. After the toxicity and pharmacodynamictests of the cell level and animal level, the specific apoptosis function of the melanotropin hormone recombinant toxin to the high expressed MC1R colon cancer cells including the human colon cancercell line HT29, colon cancer cell line HCT-116 and the like. The high expressed MC1R exist to the two cancers. The melanotropin hormone recombinant toxin has new targeting effect, is a potential therapy or add-on therapy for colorectal cancer, and has good application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the application of melanotropin-stimulating recombinant toxin in the preparation of drugs for treating colon cancer. Background technique [0002] Colon cancer is one of the most common gastrointestinal tumors. There are 1.02 million new colon cancer patients worldwide and about 530,000 deaths from colon cancer. In my country, the incidence of colorectal cancer ranks fifth among malignant tumors, and continues to grow at a growth rate of 4.2%, far higher than the international level of 2%. [0003] At present, the first choice for the treatment of colon cancer is surgical treatment. The tumor tissue is removed by surgery. However, due to the possible presence of micro-metastases, there is still a high probability of recurrence and metastasis after tumor tissue resection, so most patients with colon cancer still need to undergo surgery. Chemotherapy and radiation to reduce recurrence. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/45A61K47/42A61P35/00
CPCA61K38/45A61K47/42A61P35/00C12Y204/02
Inventor 柳溪林崔树森胡盼柳增善卢士英任洪林张嵩李萌常江
Owner JILIN UNIV
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