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Rapidly degradable chemical bond based PEG hydrogel and preparation method and applications thereof

A rapid degradation and chemical bond technology, applied in the field of PEG hydrogel, can solve the problems of inability to ensure complete removal and increase the risk of use, and achieve excellent hemostatic effect, good biocompatibility, and fast gelation.

Active Publication Date: 2018-09-14
深圳宁聚生物新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And when the operation is wrong, these traditional hemostatic sealants can only be removed by a scalpel blade, which increases the risk of use and cannot ensure complete removal

Method used

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  • Rapidly degradable chemical bond based PEG hydrogel and preparation method and applications thereof
  • Rapidly degradable chemical bond based PEG hydrogel and preparation method and applications thereof
  • Rapidly degradable chemical bond based PEG hydrogel and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Weigh 130mg of four-arm polyethylene glycol amino (as shown in formula II, wherein m is 56) and dissolve it in 1ml of normal saline to obtain mixed solution 1 (mass-volume concentration is 130mg / ml), weigh 120mg of four-arm polyethylene glycol Ethylene glycol succinimide ester (as shown in formula VI, wherein, n is 56) dissolved in 10 mg of four-arm polyethylene glycol aldehyde group (as shown in formula X, wherein, p is 56, R is formula a) Obtain mixed solution 2 (mass-volume concentration is 120mg / ml and 10mg / ml respectively) in 1ml physiological saline; Draw a kind of mixed solution with one of double-barreled syringes respectively, then inject in the cylindrical glass mould, after 30min Take it out and measure the compressive strength with a universal tensile machine, such as figure 1 As shown, the strength can reach 1.2MPa, and the strength is high.

[0082] Degradation test: Prepare a cylindrical gel with a diameter of 1cm and a height of 1cm according to the abo...

Embodiment 2

[0086] Weigh 200mg of four-arm polyethylene glycol amino (as shown in formula II, wherein m is 112) and dissolve in 1ml of PBS solution to obtain mixed solution 1 (mass-volume concentration is 200mg / ml), weigh 200mg of four-arm polyethylene glycol Ethylene glycol succinimide ester (as shown in formula VI, wherein, n is 112) and 200mg of four-arm polyethylene glycol aldehyde group (as shown in formula X, wherein, p is 112, R is formula b) dissolved Obtain mixed solution 2 (mass-volume concentration is 200mg / ml) in 1ml PBS; use one of the double-barreled syringes to draw a mixed solution, and then inject it into a transparent sample bottle at the same time, invert the sample bottle, and the time when the liquid does not flow is the gelling time. Such as figure 2 As shown, the gel time of the system is 10s, the gelation speed is fast, and it can be quickly formed on the surface of the object.

[0087] According to the method in Example 1, the degradation performance of the hyd...

Embodiment 3

[0090] Weigh 100mg of six-arm polyethylene glycol amino (as shown in formula III, wherein m is 28) and dissolve it in 1ml of PBS solution to obtain mixed solution 1 (mass-volume concentration is 100mg / ml), weigh 200mg of two-arm polyethylene glycol Ethylene glycol succinimide ester (as shown in formula V, wherein, n is 56) and 50mg of four-arm polyethylene glycol aldehyde group (as shown in formula X, wherein, p is 34, R is formula b) dissolved Obtain mixed solution 2 (mass-volume concentration is 200mg / ml and 50mg / ml respectively) in 1mlPBS; Draw a kind of mixed solution with one of double-barreled syringes respectively, be coated on the pigskin surface of fracture then, adopt universal pulling force The machine measures the pulling force required for the pigskin to separate again, which is the adhesive strength of the gel. Such as image 3 As shown, the adhesion strength is 36kPa, indicating that the gel can be well attached to the surface of pigskin and has high strength. ...

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Abstract

The invention discloses a rapidly degradable chemical bond based PEG hydrogel and a preparation method and applications thereof. The hydrogel is formed by respectively connecting a polyethylene glycolderivative 1 (polyethylene glycol amino) with a polyethylene glycol derivative 2 (polyethylene glycol succinimide ester) and a polyethylene glycol derivative 3 (polyethylene glycol aldehyde group) through a chemical bond 1 and a chemical bond 2; and the chemical bond 1 is beta-carbonyl amide bond, and the chemical bond 2 is schiff base bond. The PEG hemostasis sealing hydrogel has potential applications in the following fields: drug slow releasing materials; tissue engineering scaffolds; medical sponges; visceral organ hemostatic sealants; surface coatings of medical implants; epidermis hemostatic sealing coatings; coatings for burn treatment; and tissue adhesion preventing materials. The gelation speed of the PEG hemostasis sealing hydrogel is fast; the hydrogel can be rapidly formed onthe surfaces of objects and rapidly degraded in the body and on the body surfaces; the hydrogel has excellent hemostasis effects and good biocompatibility, and can be rapidly cleared (disappeared).

Description

technical field [0001] The invention relates to a PEG hydrogel, in particular to a PEG hemostatic hydrogel based on rapidly degradable chemical bonds, a preparation method and application thereof. Background technique [0002] Hydrogel is a soft material that can absorb a large amount of water and has a three-dimensional network structure. Hydrogels are widely used in fields such as biomedicine, agriculture, industry, and environmental protection because of their high water absorption and good biocompatibility. In terms of biomedicine, hydrogels have been used in drug carriers, cell carriers, dressings, masks, and artificial corneas. However, for some special biomedical needs, especially the hemostatic seal of organs, it is necessary to gel quickly, have high strength, and can be quickly degraded. If the operation is wrong during use, it needs to be quickly removed. [0003] In recent years, various hydrogels have been developed for hemostatic seals. Currently commerciall...

Claims

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Application Information

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IPC IPC(8): A61L27/52A61L27/18A61L27/54A61L27/50A61L31/14A61L31/06A61L31/16A61L31/10A61L24/00A61L24/04A61L26/00C08G81/00
CPCA61L24/001A61L24/0015A61L24/0031A61L24/046A61L26/0019A61L26/0061A61L26/0066A61L26/008A61L27/18A61L27/50A61L27/52A61L27/54A61L31/06A61L31/10A61L31/14A61L31/145A61L31/16C08G81/00C08L87/00
Inventor 吴德成补亚忠杨飞
Owner 深圳宁聚生物新材料科技有限公司
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