Osteochondral integrated repairing gradient hybrid support material and preparation method thereof
A scaffold material and bone cartilage technology, applied in prosthetics, additive processing, medical science, etc., can solve problems such as lack of mechanical functions, poor integration of host interface, etc., and achieve good repeatability, standardization, and simple operation.
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Embodiment 1
[0046] A method for preparing a gradient hybrid scaffold material for osteochondral integrated repair, comprising the following steps:
[0047] 1. Using computer-aided design software to establish a CAD model: a cylindrical scaffold with a diameter of 8 mm and a height of 10 mm. The scaffold consists of three parts from top to bottom: cartilage layer, cartilage calcification layer and subchondral bone layer. The thickness was 5 mm, the thickness of the calcified cartilage layer was 100 μm, the thickness of the subchondral bone layer was 5 mm, and the pore diameter of the calcified cartilage layer was 0 μm; the pore diameter of both the cartilage layer and the subchondral bone layer was 400 μm.
[0048] 2. Convert the designed CAD model into a rapid prototyping file format (STL) and import it into the 3D-Bioplotter™ printing device. Use the multi-nozzle printing system to print out the three-dimensional porous osteochondral integrated scaffold according to the preset parameters....
Embodiment 2
[0061] A method for preparing a gradient hybrid scaffold material for osteochondral integrated repair, which is basically the same as in Example 1, except that:
[0062] Established CAD model: the thickness of the cartilage layer is 2.5mm, and the thickness of the subchondral bone layer is 7.5mm;
[0063] The preparation of the cartilage layer hybrid gel is the same as in Example 1.
[0064] The preparation of the hybrid gel of the calcified cartilage layer and the subchondral bone layer is the same as in Example 1.
[0065] The set printing parameters are as follows: the internal hole structure of the bracket is rhombus.
[0066] Mechanical tests showed that the compressive strength of the integrated stent was 0.28±0.14 MPa, and the Young's modulus was 0.44±0.27 MPa.
[0067] The porosity test shows that the porosity of the integrated scaffold is (41.32±0.46)%.
Embodiment 3
[0069] A method for preparing a gradient hybrid scaffold material for osteochondral integrated repair, which is basically the same as in Example 1, except that:
[0070] The established CAD model: the thickness of the cartilage layer is 2.5 mm, the thickness of the calcification layer is 150 μm, and the thickness of the subchondral bone layer is 7.5 mm.
[0071] The preparation of the hybrid gel of the cartilage layer and cartilage calcification layer is the same as in Example 1.
[0072] In the preparation of the subchondral bone layer hybrid gel: weigh Ca(NO 3 ) 2 . 4H 2 O, H 3 PO 4 (Guarantee the molar ratio of Ca / P is 1.67) sequentially add to liquid A, stir well until mixed evenly to obtain liquid C; put the obtained milky white sol into a 3D printing barrel, and place it at a temperature of 40°C , let it stand in a constant temperature and humidity box with a humidity of 50% for 56 hours to make it fully gel;
[0073] The set printing parameters are: extrusion air...
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