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Method for preparing natural tocopherol succinate and refrigeration system thereof

A technology of tocopherol succinate and refrigeration system, applied in refrigerators, refrigeration components, refrigeration and liquefaction, etc., can solve the problems of loss of function, no longer biological activity of vitamin E, inconvenient preparation of vitamin E products, inconvenient storage, etc. Achieve the effect of high esterification rate, high purity and high content

Inactive Publication Date: 2018-09-11
JIANGSU CONAT BIOLOGICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Since the hydroxyl group on the mother ring of vitamin E chroman is easily oxidized, it no longer has the biological activity of vitamin E and loses its function, which brings a lot of inconvenience to the preparation and storage of vitamin E products.

Method used

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  • Method for preparing natural tocopherol succinate and refrigeration system thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Select the soybean deodorized distillate (the tocopherol content is 39.5%, and the specific rotation is 23.58°), add acetone to it, add 12ml of acetone per gram of the soybean deodorized distillate, and then treat it at -18°C for 45h. The measured tocopherol content increased to 54.6%.

[0029] To the deodorized distillate after acetone treatment, add succinic anhydride (addition is added according to 2.5 times of the molar amount of tocopherol in the deodorization distillate after acetone treatment), then add pyridine (addition is after every kilogram of acetone treatment Add 100ml of the deodorized distillate), and then react at 50°C for 2.5h to obtain the crude product of natural tocopherol succinate.

[0030] The prepared crude natural tocopheryl succinate was crystallized with n-hexane, the amount of n-hexane / tocopheryl succinate was 6ml / g, and crystallized at 2°C for 20h.

[0031] The product was tested, and the specific optical rotation of vitamin E in the produ...

Embodiment 2

[0033] Select the soybean deodorized distillate (the tocopherol content is 39.5%, and the specific rotation is 23.58°), add acetone to it, add 10ml of acetone per gram of the soybean deodorized distillate, and then treat it at -20°C for 40h. The measured tocopherol content increased to 53.9%.

[0034] To the deodorized distillate after acetone treatment, add succinic anhydride (addition is added according to 3 times of the molar amount of tocopherol in the deodorization distillate after acetone treatment), then add pyridine (addition is after every kilogram of acetone treatment Add 80ml of the deodorized distillate), and then react at 40°C for 2.5h to obtain natural tocopheryl succinate.

[0035] The obtained crude natural tocopheryl succinate was crystallized with n-hexane, the amount of n-hexane / tocopheryl succinate was 7ml / g, and crystallized at 4°C for 16h.

[0036] The product was tested, and the specific optical rotation of vitamin E in the product was 23.76°, the activ...

Embodiment 3

[0038] Select the soybean deodorized distillate (the tocopherol content is 39.5%, and the specific rotation is 23.58°), add acetone to it, add 10ml of acetone per gram of soybean deodorized distillate, and then treat it at -17°C for 45h. The measured tocopherol content increased to 54.1%.

[0039]To the deodorized distillate after acetone treatment, add acetic anhydride (addition is added according to 2.5 times of the molar amount of tocopherol in the deodorization distillate after acetone treatment), then add pyridine (addition is after every kilogram of acetone treatment Add 90ml of the deodorized distillate), and then react at 40°C for 3h to obtain natural tocopheryl succinate.

[0040] The prepared crude natural tocopheryl succinate was crystallized with n-hexane, the amount of n-hexane / tocopheryl succinate was 6ml / g, and crystallized at 4°C for 18h.

[0041] The product was tested, and the specific optical rotation of vitamin E in the product was 23.69°, the active ingre...

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Abstract

The invention discloses a method for preparing natural tocopherol succinate and a refrigeration system thereof. The method comprises the steps of pretreatment: adding acetone into raw materials containing natural tocopherol; performing treatment for 40 to 54 h at -20 to -17 DEG C through a refrigeration system to obtain pretreated raw materials; preparation: adding succinic anhydride and pyridineinto the pretreated raw materials; performing reaction for 2 to 3h at 40 to 50 DEG C; preparing a natural tocopherol succinate coarse product; crystallization: performing crystallization on the natural tocopherol succinate coarse product by n-hexane. In a product prepared by the method, the vitamin E content is high; the purity is high; the esterification rate is high.

Description

technical field [0001] The invention belongs to the technical field of tocopherol deep processing, and in particular relates to a method for preparing natural tocopherol succinate and a refrigeration system thereof. Background technique [0002] Since the hydroxyl group on the parent ring of vitamin E chroman is easily oxidized, it no longer has the biological activity of vitamin E, and its function is lost, which brings a lot of inconvenience to the preparation and storage of vitamin E products. [0003] Nowadays, the deep processing of vitamin E mainly focuses on the modification of the 6-position phenolic hydroxyl group on the parent ring of tocopherol. The esterification reaction can effectively protect the phenolic hydroxyl group to avoid the oxidation of free vitamin E. Common vitamin E ester derivatives include tocopheryl acetate, tocopheryl succinate, tocopheryl nicotinate, and tocopheryl vitamin A ester , tocopherol vitamin C ester, tocopherol polyethylene glycol e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/72F25B41/00F25B41/40
CPCC07D311/72F25B41/40
Inventor 陈其林吴正章方华郭春荣张鹏
Owner JIANGSU CONAT BIOLOGICAL PROD
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