Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Key vitamin D metabolism related genetic polymorphism combinations and uses

A technology of vitamins and genotypes, applied in biochemical equipment and methods, microbial measurement/testing, etc., can solve problems such as differences in vitamin D supplementation effects

Active Publication Date: 2018-08-31
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Clinically, it has been found that different individuals have different effects on vitamin D supplementation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Key vitamin D metabolism related genetic polymorphism combinations and uses
  • Key vitamin D metabolism related genetic polymorphism combinations and uses
  • Key vitamin D metabolism related genetic polymorphism combinations and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0090] The present inventors have found that genetic variation of different individuals has a significant effect on the level of 25(OH)D in vivo after vitamin D supplementation, thereby completing the present invention.

[0091] Specifically, the purpose of the present invention is to determine whether an individual is suitable for high-dose vitamin D supplementation, and when to take a subsequent high-dose vitamin D supplement after high-dose vitamin D supplementation. In the present invention, the high dose of vitamin D is usually 300,000 international units (IU) of vitamin per dose or per session.

[0092] The present invention finds that whether an individual is suitable for high-dose vitamin D supplementation and when to take a subsequent high-dose vitamin D after high-dose vitamin D supplementation is related to the total 25(OH) in blood of the individual D level, age, sex, body weight, and several genetic variation sites are related. These genetic variation loci includ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to key vitamin D metabolism related genetic polymorphism combinations and uses, and specifically provides a detection kit. The detection kit includes (1) a reagent for detectingtotal 25 (OH) D3 levels in the blood of an object; (2) a reagent for detecting the DBP haplotype of the object; (3) a reagent for detecting the genetic variation loci of the object, the genetic variation loci being as follows: rs10741657, rs7968585, rs12512631, rs2296241, rs6013897, rs2209314 and rs4809958; and (4) appliances for carrying out various tests, including but not limited to disposableblood collection appliances and containers, wherein the step (3) and (4) are optional. The detection kit can be used for analyzing or judging whether the object is vitamin D deficiency, and used for determining the medicine taking scheme of the object of taking 300,000 international units of vitamin D.

Description

technical field [0001] The present invention relates to key vitamin D metabolism-related gene genetic polymorphism combination and application. Background technique [0002] Vitamin D, a sterol derivative, is a fat-soluble vitamin that has anti-rickets effects. There are five compounds of vitamin D, vitamin D2 and vitamin D3 are more closely related to health, they have the following three characteristics: it exists in some natural foods; the human body stores 7-dehydrocholesterol produced from cholesterol under the skin, which is affected by After ultraviolet radiation, it can be converted into vitamin D3. [0003] Vitamin D obtained from food is absorbed with fat. When vitamin D is transported to the liver, it acts on the monooxygenase system in microsomes, and its 25th position is hydroxylated to form 25(OH)D. Other tissues outside the liver can also absorb vitamin D and 25(OH)D. [0004] Vitamin D deficiency can lead to rickets in children and rickets in adults. Rick...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156
Inventor 王慧陈培战段晓华
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com