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Method of treatment and prognosis

A level, subject technology, applied in the direction of biochemical equipment and methods, material inspection products, instruments, etc., can solve the problem of low rate of successful clinical pregnancy

Pending Publication Date: 2018-08-24
HUDSON INST OF MEDICAL RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Low rates of successful clinical pregnancies despite increased use of assisted reproductive technologies

Method used

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  • Method of treatment and prognosis
  • Method of treatment and prognosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0155] natural cycle queue

[0156] Uterine lavage and endometrial biopsies from 19 fertile women and 18 women with primary idiopathic infertility were staged as early secretion. There was no significant difference in age between the fertile (36.7±4.0 years) and infertile (35.2±5.3 years) groups. Detailed history and pathology reports revealed a mixture of uterine lesions and bleeding abnormalities in the patient cohort (Table 2). exist figure 1 The levels of biomarkers in uterine lavages are shown.

[0157] Concentrations of individual analytes in uterine lavages from fertile and infertile women during the early secretory phase of the cycle were compared by Mann-Whitney test and ROC analysis (Table 3). By Mann-Whitney, only CSF3 showed a significant difference between fertile women (mean=1300+ / -435.8pg / mL) and infertile women (mean=3309+ / -705.4pg / mL) in early secretion samples Difference (p=0.006). No other markers showed significant differences between fertile and infer...

Embodiment 2

[0161] Analysis of lavages from women undergoing ART

[0162] Concentrations of CSF3 in uterine lavages from women on hCG+2 during stimulation cycles were compared. Patients were divided into three groups based on cycle results: pregnant, non-pregnant, and preclinically pregnant, with a fourth group comprising fertile women undergoing IVF stimulation as egg donors. Concentrations of CSF3 were significantly different between groups (Kruskal-Wallisp = 0.0002), compared with achieved pregnancy (mean ± SEM, 1245 ± 269), preclinical pregnancy (mean ± SEM, 1992 ± 40) and fertile women stimulated Egg donors (mean ± SEM, 719 ± 274) were elevated in non-pregnant women (mean ± SEM, 3447 ± 89) ( image 3 ). Individual pairwise analysis (Dunn's test) showed significant differences between the "non-pregnant" and "pregnant" (p=0.041 ) and "donor" (p=0.025) groups.

Embodiment 3

[0164] Detection of CSF3 and its receptors in uterine tissue

[0165] Immunohistochemistry of CSF3 in early secretory-phase tissues showed a usual expression pattern in luminal and glandular epithelium, and to some extent stromal expression, similar to that previously reported for mid-secretory tissues. However, there was no clear difference in the staining pattern of CSF3 between fertile and infertile women. The result is as figure 2 shown.

[0166] CSF3 receptors showed parenchymal staining in both the luminal and glandular epithelium of fertile females during the early secretory phase of the cycle, in contrast to weaker stroma staining. However, in idiopathic infertile women, the epithelial expression of CSF3R was greatly reduced or even disappeared, whereas the stromal staining was stronger.

[0167] In a small cohort of IVF tissues sampled with hCG+2, there was a similar pattern of strong glandular epithelial staining in tissues from fertile egg donors undergoing IVF ...

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Abstract

The present disclosure teaches an assay to determine the likelihood of a successful implantation of an embryo into a female subject leading to a pregnancy and a method of treatment to facilitate same.Enabled herein is an improved assisted reproduction technology protocol based on a prognostic evaluation of pregnancy outcomes and the identification of therapeutic targets. Taught herein is a composition comprising reagents required for prognostic evaluation and treatment. The present disclosure teaches an assay to determine the risk that a pregnant woman may undergo a miscarriage. Biomarkers used in the assays include CSF3, CSF3R, IL-17A or P1GF.

Description

[0001] submit data [0002] This application is related to, and claims priority from, Australian Provisional Patent Application No. 2015903979 entitled "A Method of Treatment and Prognosis", filed 30 September 2015, the entire contents of which are incorporated herein by reference. technical field [0003] The present disclosure teaches an assay to determine the likelihood that successful implantation of an embryo into a female subject will result in pregnancy, as well as methods of treatment to promote pregnancy. This article provides an improved assisted reproductive technology approach and identification of therapeutic targets. Compositions comprising reagents needed for prognostic assessment and treatment are taught herein. Background technique [0004] Bibliographic details of publications mentioned by authors in this specification are collected alphabetically at the end of the specification. [0005] The reference to any prior art in this specification is not and sho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N2333/475G01N2333/5412G01N2333/5421G01N2333/471G01N2333/54G01N2800/36G01N2333/52G01N2333/535G01N33/689C12Q1/68G01N33/68G01N2333/53G01N2333/5446G01N2800/367C12Q2600/112G01N2333/4737G01N2800/368
Inventor T·A·艾杰尔L·A·萨拉蒙森
Owner HUDSON INST OF MEDICAL RES
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