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Traditional Chinese medicine compound preparation for treating ovarian tumor and application thereof

A compound preparation, ovarian tumor technology, applied in the direction of antitumor drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc. Significant effect, high inhibition rate effect

Active Publication Date: 2018-08-24
HUANGHUAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, currently known anti-ovarian cancer traditional Chinese medicines have many medicinal flavors, which are not easy to prepare. To a certain extent, they also have the defects of redundant medicinal flavors and poor effects. At present, there is an urgent need for medicinal flavors that are simple in composition, less effective, and more effective in inhibiting cancer cells. Significant and safe traditional Chinese medicine preparation

Method used

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  • Traditional Chinese medicine compound preparation for treating ovarian tumor and application thereof
  • Traditional Chinese medicine compound preparation for treating ovarian tumor and application thereof
  • Traditional Chinese medicine compound preparation for treating ovarian tumor and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Prepare Chinese medicine compound preparation of the present invention according to the following methods:

[0038]1) Weigh each raw material by weight: 25 parts of Panax notoginseng, 25 parts of Hedyotis diffusa, 5 parts of Eupatorium euphratica, pulverize through an 80-mesh sieve, add 6 times the amount of ethanol with a volume fraction of 85%, soak at room temperature 15 hours, 85 ° C water bath reflux extraction twice, each time 2 h, combined filtrate, concentrated to the concentration of 1.5 g crude drug / ml extract, dried at 45 ° C to constant weight, that is, Panax notoginseng, Hedyotis diffusa and Alcoholic extract of eupatorium;

[0039] 2) Mix the alcohol extracts of Panax notoginseng, Hedyotis diffusa and Eupatorium in step 1) with platycodon saponin D and geniposide, and the weight ratio of the three is 8:1:1;

[0040] 3) adding a conventional pharmaceutical carrier to the mixture in step 2) to prepare the traditional Chinese medicine compound preparation. ...

Embodiment 2

[0042] Prepare Chinese medicine compound preparation of the present invention according to the following methods:

[0043] 1) Weigh the raw materials by weight: 20 parts of Panax notoginseng, 30 parts of Hedyotis diffusa, 5 parts of Eupatorium euphratica, pulverize through a 60-mesh sieve, add 10 times the amount of ethanol with a volume fraction of 80%, soak at room temperature For 20 hours, reflux extraction in 80°C water bath for 3 times, each time for 1h, combine the filtrate, concentrate to an extract with a concentration of 1g crude drug / ml, and dry to constant weight at 50°C to obtain Panax notoginseng, Hedyotis diffusa and Ze Alcoholic extract of blue;

[0044] 2) Mix the alcohol extracts of Panax notoginseng, Hedyotis diffusa and Eupatorium in step 1) with platycodon saponin D and geniposide, and the weight ratio of the three is 7:1.2:1.2;

[0045] 3) adding a conventional pharmaceutical carrier to the mixture in step 2) to prepare the traditional Chinese medicine co...

Embodiment 3

[0047] Prepare Chinese medicine compound preparation of the present invention according to the following methods:

[0048] 1) Weigh each raw material by weight: 30 parts of Panax notoginseng, 20 parts of Hedyotis diffusa, 10 parts of Eupatorium, pulverize through an 80-mesh sieve, add 5 times the amount of ethanol with a volume fraction of 90%, soak at room temperature 10 hours, 90 ° C water bath reflux extraction twice, 3 hours each time, combined filtrate, concentrated to 2 g crude drug / ml extract, dried at 40 ° C to constant weight, that is, Panax notoginseng, Hedyotis diffusa and Ze Alcoholic extract of blue;

[0049] 2) Mix the alcohol extracts of Panax notoginseng, Hedyotis diffusa and Eupatorium in step 1) with platycodon saponin D and geniposide, and the weight ratio of the three is 10:0.8:1.2;

[0050] 3) adding a conventional pharmaceutical carrier to the mixture in step 2) to prepare the traditional Chinese medicine compound preparation.

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Abstract

The invention relates to a traditional Chinese medicine compound preparation for treating ovarian tumor and application thereof. The traditional Chinese medicine compound preparation is prepared by using an alcohol extract of radix notoginseng, spreading hedyotis herb and herba lycopi, platycodin D and geniposide as active ingredients, wherein the alcohol extract is prepared according to the following steps: weighing 20 to 30 parts of radix notoginseng, 20 to 30 parts of spreading hedyotis herb and 5 to 10 parts of herba lycopi, crushing, adding 5 to 10 times of ethyl alcohol with volume fraction of 80% to 90%, soaking for 10 to 20 hours at room temperature, refluxing in a water bath of 80 DEG C to 90 DEG C for two to three times, each time for 1 to 3 h, then combining filtrate, concentrating the filtrate into an extracting solution with the concentration of 1 to 2g / ml, and drying the extracting solution at 40 DEG C to 50 DEG C to be constant in weight. The traditional Chinese medicinecompound preparation provided by the invention has the advantages that tumor growth can be significantly inhibited, the platycodin D and the geniposide have certain synergistic effects, less medicinematerials are used, the medicine efficacy is specialized, the safety is high, and the development and promotion of clinical medicine is facilitated.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a compound traditional Chinese medicine preparation for treating ovarian tumors and its application. Background technique [0002] Ovarian tumors refer to tumors that occur on the ovary, among which ovarian cancer is the tumor with the highest mortality rate among gynecological malignancies, and has become a difficult and hot spot in the research of gynecological tumors at home and abroad. The treatment of ovarian cancer is mainly based on surgery, which is generally combined with chemotherapy, radiotherapy, and drug therapy. Compared with pure western medicine treatment, integrated traditional Chinese and western medicine treatment has certain advantages, and it plays an important role in improving symptoms, consolidating curative effect, reducing recurrence and metastasis, improving quality of life, and prolonging survival time. For example, g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/748A61P35/00A61K31/704A61K31/7048
CPCA61K31/704A61K31/7048A61K36/258A61K36/53A61K36/748A61K2236/333A61K2236/39A61P35/00A61K2300/00
Inventor 张静高冬冬陈均伟谷云鹏党真
Owner HUANGHUAI UNIV
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