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Shuanghuanglian effervescence tablet and its preparation

A technology of Shuanghuanglian and effervescent tablets, which can be used in pharmaceutical formulas, medical preparations containing active ingredients, drug delivery, etc., and can solve the problems of waste of resources and low extraction rate of active ingredients

Inactive Publication Date: 2004-11-10
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, Shuanghuanglian preparations are extracted by decoction pieces or native medicines (Chinese Pharmacopoeia 2000 edition one, Shuanghuanglian oral liquid, Shuanghuanglian granules, Shuanghuanglian suppository), which have the disadvantages of low extraction rate of active ingredients and waste of resources. It is extracted after pulverization by micro-pulverization equipment, which has the characteristics of complete dissolution of active ingredients and high extraction efficiency.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1. Prescription Honeysuckle 750g Scutellaria 750g Forsythia 1500g

[0016] Take the prescribed amount of medicinal materials, dry them at low temperature, and pulverize them with a Bailey powder machine for use. Take the Scutellaria baicalensis powder, add water and decoct three times, the first time is 2 hours, the second and third time are each 1 hour, combine the decoction, filter, and concentrate the filtrate to an appropriate amount. Add 2mol / L hydrochloric acid solution to the concentrate at 80℃ to adjust the pH value To 1.0-2.0, keep for 24 hours after heat preservation for 1 hour, filter, add 6-8 times the amount of water to the precipitate, adjust the pH value to 7.0-7.5 with 40% sodium hydroxide solution, add the same amount of ethanol, stir to dissolve , Filtered. The filtrate was adjusted to pH 2.0 with 2mol / L hydrochloric acid solution, incubated at 60°C for 30 minutes, allowed to stand for 12 hours, filtered, and the precipitate was washed with water to pH 5.0...

Embodiment 2

[0018] 1. Prescription Honeysuckle 750g Scutellaria 750g Forsythia 1500g

[0019] Take the prescribed amount of medicinal materials, dry them at low temperature, and pulverize them with a Bailey powder machine for use. Take the Scutellaria baicalensis powder, add water and decoct for three times, the first time is 2 hours, the second and third time are 1 hour each, combine the decoction, filter, and concentrate the filtrate to an appropriate amount. Add 2mol / L hydrochloric acid solution to the concentrate at 80℃ to adjust the pH value To 1.0-2.0, keep for 24 hours after heat preservation for 1 hour, filter, add 6-8 times the amount of water to the precipitate, adjust the pH value to 7.0-7.5 with 40% sodium hydroxide solution, add the same amount of ethanol, stir to dissolve , Filtered. The filtrate was adjusted to pH 2.0 with 2mol / L hydrochloric acid solution, incubated at 60°C for 30 minutes, allowed to stand for 12 hours, filtered, and the precipitate was washed with water to pH...

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PUM

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Abstract

The invention relates to a Shuanghuanglian effervescent tablet and method for preparing same, wherein the effervescent tablet comprises Shuanghuanglian concrete powder, crumbling agent, lubricating agent and sweetener, wherein the medicinal material is disintegrated by micro disintegrating apparatus for extraction with high dissolving rate of active ingredients. Pharmacological experiment has shown that the Shuanghuanglian heat effervescent tablet has better analgesic and anti-inflammatory action than the Shuanghuanglian oral liquid.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and more specifically relates to a Shuanghuanglian effervescent tablet and a preparation method thereof. Background technique [0002] Cold is a common and frequently-occurring disease in clinical practice, mainly manifested as fever, cough, sore throat and other symptoms. The disease has a high incidence and a large demand for drugs. The traditional Chinese medicine Shuanghuanglian oral liquid is composed of three Chinese medicines of honeysuckle, scutellaria baicalensis and forsythia. It has the effects of pungent cooling to relieve the surface, clearing away heat and detoxification, and is mainly used for the treatment of fever, cough and sore throat caused by exogenous wind-heat. At present, its dosage forms are mainly Shuanghuanglian oral liquid, Shuanghuanglian tablets, Shuanghuanglian freeze-dried powder injection, Shuanghuanglian injection, Shuanghuanglian aerosol, Shuanghu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/46A61P11/04A61P11/14A61P31/00
Inventor 张晴龙
Owner 张晴龙
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