Graphene and hydroxyapatite composite biomimetic bone material and preparation method thereof

Abstract

The invention discloses a composite biomimetic bone material of graphene and hydroxyapatite and a preparation method thereof. The method comprises: mixing an aqueous calcium hydroxide solution and a phosphorus source solution according to a Ca / P molar ratio of 1.67 to form hydroxyapatite , adding water-soluble graphene with a stoichiometric ratio of 2.5%-25% of the mass of the synthesized hydroxyapatite, and obtaining a uniform black solution after ultrasonication for 5 minutes; adding the black solution to the polar solution, and reacting at 200 degrees Celsius for 12-36 hours , cooled to room temperature to obtain a mixed solution; the mixed solution was centrifugally washed with deionized water to neutrality to obtain a black crude product; and the black crude product was ultrasonically dispersed in deionized water and pre-frozen to obtain graphene / hydroxyphosphorus Greystone biomimetic bone material. The product obtained in the present invention has high biocompatibility, has a good proliferation effect on osteoblasts, can quickly complete the repair of bone defects, and has good biodegradability, and can be used in disease prevention, biomedicine, targeted drugs, Environmental protection and other industries.

Description

Graphene and hydroxyapatite composite biomimetic bone material and preparation method thereof technical field [0001] The present invention relates to the field of medical bionic materials, in particular to a preparation method of a medical bone material. Background technique Hydroxyapatite (Hydroxyapatite, HA) is the white powder of hexagonal crystal system, and chemical composition is Ca 10 (PO4) 6 (OH) 2 , with a specific gravity of 3.16 grams per cubic centimeter and a Mohs hardness of 5, similar to natural apatite minerals. HA is human skeletal tissue And the main inorganic component of teeth, its content in enamel is about 96%, and it can also account for more than 69% in bone. relatively Compared with traditional metal (stainless steel, titanium alloy) and ceramic (alumina, silicon nitride) bone replacement materials, HA bioactive ceramics do not It has only strong corrosion resistance, can form a bone bonding interface with bone, has high bonding s...

AI Technical Summary

Problems solved by technology

However, the preparation method disclosed in the patent also needs to limit the reaction conditions such as initiator, catalyst and nitrogen protection, and the reaction product is prone to other impurity ions

Images