Preparation method of lacrimal duct plug with medicine slow release function

Abstract

The invention discloses a preparation method of a lacrimal duct plug with a medicine slow release function. The method comprises the following steps of (1) uniformly mixing preparation raw materials of the lacrimal duct plug; injecting the materials into a mold; (2) performing reaction for 18 to 26h in the mold at 25 to 88 DEG C; performing curing shaping to obtain primarily shaped water gel; (3)performing UV irradiation on the primarily shaped water gel obtained in the step (2) for 5 to 30 min; performing further curing and shaping to obtain shaped water gel; (4) taking out the shaped watergel obtained in the step (3) from the mold; performing soaking and washing for 2 to 4 days by clean water; then, taking out the water gel; performing drying; obtaining the lacrimal duct plug with themedicine slow release function. The lacrimal duct plug uses hydroxyethyl methacrylate as a substrate; the medicine can be loaded; after the implementation by operation, the water absorption expansioncan be realized; the self fixing effect is achieved; the operative operation is facilitated; the medicine release speed can be regulated in a controllable way; the long-time implementation can be realized; the repulsion and the inflammation can be reduced; the excellent biocompatibility is realized.

Description

technical field [0001] The invention relates to a preparation method of a polymer material, in particular to a preparation method of a lacrimal canaliculus plug with drug sustained release function. Background technique [0002] Dry eye, also known as keratoconjunctival sicca, refers to a class of diseases that cause ocular discomfort symptoms due to tear film instability and ocular surface damage caused by abnormal tear quality and quantity or tear fluid dynamics. The clinical symptoms of dry eye usually manifest as dryness, foreign body, pain, burning, itching, blurred vision, red eyes, photophobia, tearing, etc. Lacrimal canalicular embolization using various emboli is a relatively new technique for sealing the lacrimal duct. By mechanically blocking the lacrimal duct, the discharge of tear fluid is reduced, the balance of tear fluid on the ocular surface is re-established, and the environment of the ocular surface is improved, thereby significantly reducing the pain of p...

AI Technical Summary

Problems solved by technology

However, silica gel is the raw material and is hydrophobic. It needs lubricating oil to assist in implantation, and the implantation period generally does not exceed one month. Therefore, it needs to be replaced after the expiration date, and it needs to be removed by a second operation. Secondary damage often occurs, leading to bleeding, inflammation, etc. reaction, resulting in granulation hyperplasia and other phenomena

There are also lacrimal canaliculus plugs obtained from materials such as polydioxanone, acrylic acid, and medical silicone rubber. The biocompatibility of this type of material is relatively poor, and long-term implantation is likely to induce body rejection and chronic inflammation

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