External use wound surface hemostasis flushing liquid

A technology for flushing liquid and wound surface, which is applied in the field of external wound hemostatic flushing liquid component of early debridement and irrigator, which can solve the problems of blurred surgical field and increased transient exudation of wound surface, so as to avoid adverse reactions, improve application range expansion, The effect of improving the efficiency of drug use

Inactive Publication Date: 2018-08-14
张涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Another object of the present invention is to propose a wound hemostatic flushing solution for external use, which can overcome the problem of blurred surgical field due to transient exudation of the wound during flushing and debridement, and clear surgical field during debridement is beneficial to improve wound debridement. efficiency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, a composition of topical wound hemostatic irrigation solution.

[0023] An external wound hemostatic washing liquid, including nicotine, pure water and sodium sulfite.

[0024] The solute hemostatic drug in the external wound hemostatic washing solution is nicotine, and its purity is 99.9%. The oxidizing agent is sodium sulfite with a purity of 99.0%.

[0025] The nicotine content of the solute component in the wound hemostatic flushing liquid has the highest value of 0.0001%, the lowest value of 0.00001%, and the middle value of 0.00005%.

[0026] The pure water content ratio of the solvent component in the wound hemostatic flushing solution has the highest value of 99.99998%, the lowest value of 99.99976%, and the middle value of 99.99987%.

[0027] The antioxidant content of the solute component sodium sulfite in the wound hemostatic flushing solution has the highest value of 0.00014%, the lowest value of 0.00001%, and the middle value of 0.00007%.

Embodiment 2

[0028] Example 2, a pharmacological action design of components in a topical wound hemostatic irrigation solution.

[0029] The purity of the nicotine is 99.9%, and its aqueous solution components are combined with the nicotinic receptors on the broken ends of the capillaries and lymphatic vessels on the wound surface to produce a neurotransmitter-mimetic vasoconstriction physiological effect, persistently block the broken ends of the lumen, and promote The internal opening of the broken end quickly produces insoluble tissue emboli, which realizes wound hemostasis, reduces wound exudation, and effectively prevents blood and body fluids from being lost through the wound.

[0030] The pure water is used to dilute the solute sodium sulfite and nicotine, adjust and maintain the physical and chemical properties of nicotine and sodium sulfite, and carry nicotine as a liquid carrier to wash the wound surface, so that nicotine can fully contact with the nicotinic receptors on the wound...

Embodiment 3

[0032] Example 3, a procedure for preparing a wound hemostatic flushing solution for external use.

[0033] It is produced according to the process standard of class II medical device specification.

[0034] Step 1: A standard 0.01 mol / L sodium sulfite solution (PH=9.59) is used as the bulk drug.

[0035] Step 2: Calculate the required mass of 0.01mol / L sodium sulfite solution (12.6g sodium sulfite / L) according to the required solution volume. Weigh an appropriate amount of 0.01mol / L sodium sulfite solution into a sterile container, add pure water to dissolve, dilute and mix well.

[0036] Step 3: Accurately measure the medicinal nicotine standard product with a purity of 99.9%, and prepare a 0.01mol / L nicotine solution as a raw material drug.

[0037] Step 4: Calculate the required mass of 0.01mol / L nicotine solution (16.22g nicotine / L) according to the required solution volume. The balance weighs an appropriate amount of 0.01mol / L nicotine solution and puts it into 0.0000...

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PUM

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Abstract

The invention relates to the technical field of a medical appliance accessory, in particular to an external use wound surface hemostasis flushing liquid assembly for an early stage wound cleaning flushing device. The ingredients comprise nicotine medical use standard products, pure water and sodium sulfite; the nicotine ingredients are combined with nicotine receptors on the wound surface capillary vessels and lymphatic vessel broken ends; the effects of shrinkage the blood vessel broken ends can be generated. The pure water is sterile injection water and is used for diluting the solute of sodium sulfite and nicotine; the sodium sulfite has the anti-oxidization effect; the physicochemical property stability is maintained by the anti-oxidization effect of sodium sulfite; the long-time storage and transportation of the hemostasis flushing liquid is convenient. Through the flushing liquid fluid, the nicotine is brought to the wound surface tissues; the wound tissue surface is uniformly coated; the relying degree on the blood coagulation factors in the hemostasis process can be reduced by the hemostasis flushing liquid; the wound surface deep layer blood vessel shrinkage effect cannotbe generated; the wound surface remote end limb blood supply obstacle cannot be caused; the whole body toxic and side effects irrelevant to the treatment cannot be generated. The operators can conveniently and fast complete the wound clearing flushing procedure.

Description

technical field [0001] The invention relates to the field of medical device accessories, in particular to an external wound hemostatic irrigation liquid assembly for an early debridement and irrigation device. Background technique [0002] The early debridement and irrigator is an important medical device for medical staff to wash, debride, disinfect and stop the wound process on the spot. The topical wound hemostatic irrigation solution is an important part of the early debridement and irrigation device. The performance and convenience of wound hemostatic irrigation fluid have an important impact on the medical function of early debridement and irrigation device, so wound hemostatic irrigation fluid plays a key role in the process of early debridement and irrigation on site. [0003] In special unstable environments such as emergency relief and battlefields, the early debridement and irrigator can complete the cleaning and debridement treatment of polluted wounds under sim...

Claims

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Application Information

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IPC IPC(8): A61K33/04A61K31/465A61P17/02A61P7/04
CPCA61K31/465A61K33/04A61P7/04A61P17/02A61K2300/00
Inventor 张涛韩松鱼敏
Owner 张涛
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